Prenatal developmental toxicity evaluation of IDM01, a botanical composition of 4-hydroxyisoleucine and trigonelline based standardized fenugreek seed extract, during organogenesis period of pregnancy in rats
Abstract:The present study was undertaken to assess the developmental toxicity of botanical composition of standardized fenugreek seed extract with markers 4-hydroxyisoleucine and trigonelline (IDM01) during organogenesis period of pregnancy in rats in accordance with OECD guideline (No. 414). Pregnant rats were administered by gavage at 125, 250, and 500 mg/kg per day of IDM01 over the exposure period of gestational days 5-19 (GD5-GD19). The vehicle control (VC) group was also maintained. The cesarean sections of dams… Show more
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