Prenatal depression effects on the fetus and the newborn

Field, Tiffany; Diego, Miguel; Dieter, John N.I.; Hernandez‐Reif, Maria; Schanberg, Saul M.; Kuhn, Cynthia M.; Yando, Regina; Bendell, Debra

doi:10.1016/j.infbeh.2003.09.010

Cited by 329 publications

(184 citation statements)

References 27 publications

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“…Because SRIs readily cross the placenta and the blood-brain barrier (19), concerns have been raised about the developmental consequences of altered fetal 5-HT signaling (12,20) or other downstream consequences (21) following prenatal SRI exposure. Importantly, antenatal maternal mood disturbances also have adverse consequences on later cognitive and language development (22)(23)(24) and affect early 5-HT levels (25), leading to confusion about how to distinguish the developmental impact of SRIs from antenatal maternal mood disturbances.…”

mentioning

confidence: 99%

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Weikum

Oberlander

Hensch

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

172

107

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Language acquisition reflects a complex interplay between biology and early experience. Psychotropic medication exposure has been shown to alter neural plasticity and shift sensitive periods in perceptual development. Notably, serotonin reuptake inhibitors (SRIs) are antidepressant agents increasingly prescribed to manage antenatal mood disorders, and depressed maternal mood per se during pregnancy impacts infant behavior, also raising concerns about long-term consequences following such developmental exposure. We studied whether infants' language development is altered by prenatal exposure to SRIs and whether such effects differ from exposure to maternal mood disturbances. Infants from non-SRI-treated mothers with little or no depression (control), depressed but non-SRI-treated (depressed-only), and depressed and treated with an SRI (SRI-exposed) were studied at 36 wk gestation (while still in utero) on a consonant and vowel discrimination task and at 6 and 10 mo of age on a nonnative speech and visual language discrimination task. Whereas the control infants responded as expected (success at 6 mo and failure at 10 mo) the SRI-exposed infants failed to discriminate the language differences at either age and the depressed-only infants succeeded at 10 mo instead of 6 mo. Fetuses at 36 wk gestation in the control condition performed as expected, with a response on vowel but not consonant discrimination, whereas the SRI-exposed fetuses showed accelerated perceptual development by discriminating both vowels and consonants. Thus, prenatal depressed maternal mood and SRI exposure were found to shift developmental milestones bidirectionally on infant speech perception tasks.L anguage, our most quintessential human characteristic, involves a complex interplay between biology and experience. At birth, infants possess an initial preparedness for language and a developmental readiness that supports learning any of the world's languages (1-3), yet also already show privileged processing to the native language from prenatal listening experience (4-6). During the following weeks and months of life, infants become progressively attuned to the properties of their native language, including its rhythmical and segmental (e.g., consonant) information (reviewed in refs. 7 and 8). The high degree of regularity in the timing of sequential tuning to properties of the native language suggests a series of critical or sensitive periods, i.e., points in development when the system is maximally influenced by input.The timing of onset of these sensitive periods seems to be maturationally constrained. Infants born 3 mo preterm attune to the phonetic properties (9) of their native language at the same gestational age as full-term infants, not according to the number of months of postnatal listening experience. Such maturational constraints can protect development: ensuring the optimal consecutive stabilization of the perceptual components that contribute in a step-wise fashion to language acquisition (10). However, it is known from research i...

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mentioning

confidence: 99%

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Weikum

Oberlander

Hensch

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

172

107

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“…Shaikh et al (2011) used A-Z stress scale. Moreover CES-D was used to assess depression (Diego et al, 2009;Field et al, 2004Field et al, , 2006Shaikh et al, 2011). The varied variables for instance live events, daily hassles, social support used in different studies to assess stress during pregnancy makes it difficult to compare the outcomes as varied measures are used.…”

Section: Discussionmentioning

confidence: 99%

“…Field et al (2004) compared 70 pregnant women with and without depression at 20 weeks of gestation by using the CES-D. The study findings showed a significantly greater number of premature births in depressed women as compared to non-depressed women (25% versus 7%, P < 0.01).…”

Section: Relationship Between Stress or Depression Cortisol And Pretmentioning

confidence: 96%

“…Two studies examined the relationship between stress and cortisol only (Harville et al, 2009;Obel et al, 2004) while five studies only explored the relationship between cortisol and preterm birth (Campbell, Challis, DaSilva, & Bocking, 2005;Phocas, Sarandakou, & Rizos, 1990;Mazor et al, 1994Mazor et al, , 1996Sandman et al, 2006). Of the 22 articles seven determined the relationship between stress or depression, cortisol and preterm birth together at the same time (Diego et al, 2009;Erickson et al, 2001;Field et al, 2004Field et al, , 2006Hobel et al, 1999;Kramer et al, 2009;Shaikh et al, 2011).…”

Section: Overview Of the Included Studiesmentioning

confidence: 99%

“…A few studies have been carried out to identify the relationship between maternal depression, cortisol levels, and preterm delivery and these show a significant relationship between the three variables (see Table 2) (Diego et al, 2009;Field et al, 2004Field et al, , 2006Field, Diego, Hernanzer-Rief et al, 2008). Field et al (2004) compared 70 pregnant women with and without depression at 20 weeks of gestation by using the CES-D.…”

Section: Relationship Between Stress or Depression Cortisol And Pretmentioning

confidence: 99%

See 2 more Smart Citations

The Relationship between Prenatal Stress, Depression, Cortisol and Preterm Birth: A Review

Shaikh¹,

Premji²,

Khowaja³

et al. 2013

OJD

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Preterm birth is one of the most common adverse pregnancy outcomes. Maternal risk factors such as stress and depression have been associated with preterm birth. Preterm infants are at a higher risk of poor growth and neuro developmental outcomes. The objective of this paper is to examine the relationship between maternal stress, depression, cortisol level, and preterm birth. Preterm birth is one of the most common adverse pregnancy outcomes with a global prevalence of 9.6% and one of the major contributors to infant mortality and morbidity. The association between psychosocial stress and preterm birth, although examined for more than 25 years, has not yet been fully established. A systemic review was conducted in which research studies and review articles from 1970 to 2012, published in English, focusing on human subjects, and addressing the relationship between stress, depression, cortisol and preterm birth were included in this review. The studies examining the relationship between stress, cortisol levels and preterm birth have shown inconsistent findings that may be explained by varied study designs, differences in defining and measuring stress, timing of stress measurement, sample characteristics, and study designs. The relationship between stress, cortisol levels and preterm birth may be multifactorial and complex with premature birth being the final common pathway. A longitudinal cohort study, with a large sample size and multiple measures of stress, depression, and cortisol level, as well as a measure of anxiety and other stress hormone biomarkers may add new knowledge and enhance our understanding about the contribution of psychosocial stress to preterm birth.

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Externalizing and Attentional Behaviors in Children of Depressed Mothers Treated With a Selective Serotonin Reuptake Inhibitor Antidepressant During Pregnancy

Oberlander¹,

Reebye²,

Misri³

et al. 2007

Arch Pediatr Adolesc Med

170

141

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Prenatal depression effects on the fetus and the newborn

Cited by 329 publications

References 27 publications

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

The Relationship between Prenatal Stress, Depression, Cortisol and Preterm Birth: A Review

Externalizing and Attentional Behaviors in Children of Depressed Mothers Treated With a Selective Serotonin Reuptake Inhibitor Antidepressant During Pregnancy

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