Prenatal depression and 5‐<scp>HTTLPR</scp> interact to predict dysregulation from 3 to 36 months – A differential susceptibility model

Babineau, Vanessa; Green, Cathryn Gordon; Jolicoeur-Martineau, Alexis; Bouvette‐Turcot, Andrée‐Anne; Minde, Klaus; Sassi, Roberto; St‐André, Martin; Carrey, Normand; Atkinson, Leslie; Kennedy, James L.; Lydon, John; Steiner, Meir; Gaudreau, Hélène; Levitan, Robert D.; Meaney, Michael J.; Wazana, Ashley

doi:10.1111/jcpp.12246

Cited by 58 publications

(47 citation statements)

References 51 publications

(89 reference statements)

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“…Existing tests of differential susceptibility and related theories focus on postpartum or early life environmental exposures. To our knowledge, Babineau et al (2014) is the only other study to evaluate differential susceptibility to the prenatal environment. Babineau et al evaluated the interaction of prenatal depression and a genetic susceptibility factor (5-HTTLPR) on mother-reported child behavioral/emotional dysregulation, and did not evaluate the impact of a positive prenatal environment.…”

Section: Discussionmentioning

confidence: 99%

“…Theories of differential susceptibility have rarely been extended to encompass the prenatal environment. In an exception, Babineau et al (2014) recently demonstrated a differential susceptibility effect in which prenatal maternal depression interacted with genetic susceptibility (5-HTTLPR genotype) to predict mother-rated dysregulation in 3–6 month old infants. Infants with susceptible genotypes demonstrated higher dysregulation after exposure to maternal prenatal depression, but less dysregulation when prenatal depression was low.…”

Section: Introductionmentioning

confidence: 99%

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Effects of prenatal factors and temperament on infant cortisol regulation in low‐income Mexican American families

Luecken

MacKinnon

Jewell

et al. 2015

Developmental Psychobiology

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Prenatal psychosocial exposures can significantly affect infant health and development. Infants with higher temperamental negativity are theorized to be more susceptible to environmental exposures. We evaluated the interaction of prenatal maternal exposures and infant temperamental negativity to predict infant cortisol response to mildly challenging mother-infant interaction tasks. Participants included 322 Mexican American mother-infant dyads (mother age 18–42; 82% Spanish-speaking; modal family income $10,000–$15,000). Mothers reported depressive symptoms and social support prenatally and infant temperamental negativity at 6 weeks postpartum. Salivary cortisol was collected from infants before and after mother-infant interaction tasks at 12 weeks. Higher prenatal maternal depressive symptoms and lower social support predicted higher cortisol among infants with higher temperamental negativity. Higher infant temperamental negativity predicted an increase in maternal distress and a decrease in social support from prenatal to 12 weeks postpartum. Interactive influences of maternal social-contextual factors and infant temperament may influence the development of infant neurobiological regulation and promote or strain maternal and infant adaptation over time.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of prenatal factors and temperament on infant cortisol regulation in low‐income Mexican American families

Luecken

MacKinnon

Jewell

et al. 2015

Developmental Psychobiology

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show abstract

“…Following the same theory, a recent study proposes that the 5-HTTLPR genotype interacts with prenatal depression in predicting childhood dysregulation (failures in regulating or controlling thoughts, emotions and behaviors) in a for better-and-for-worse manner. Children carrying the S or L G alleles have higher levels of dysregulation when exposed to prenatal depression, whereas higher capacity for regulation when exposed to lower or little prenatal depression (Babineau et al , 2015). …”

Section: Is the “Differential Susceptibility” Model Relevant For Omentioning

confidence: 99%

Gene and environment interaction: Is the differential susceptibility hypothesis relevant for obesity?

Molle

Fatemi

Levitan

et al. 2017

Neuroscience & Biobehavioral Reviews

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The differential susceptibility model states that a given genetic variant is associated with an increased risk of pathology in negative environments but greater than average resilience in enriched ones. While this theory was first implemented in psychiatric-genetic research, it may also help us to unravel the complex ways that genes and environments interact to influence feeding behavior and obesity. We reviewed evidence on gene vs. environment interactions that influence obesity development, aiming to support the applicability of the differential susceptibility model for this condition, and propose that various environmental “layers” relevant for human development should be considered when bearing the differential susceptibility model in mind. Mother-child relationship, socioeconomic status and individual's response are important modifiers of BMI and food intake when interacting with gene variants, “for better and for worse”. While only a few studies to date have investigated obesity outcomes using this approach, we propose that the differential susceptibility hypothesis is in fact highly applicable to the study of genetic and environmental influences on feeding behavior and obesity risk.

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“…Over the past decade, numerous reports have appeared documenting such GϫE interplay (e.g., Babineau et al, 2015;Bresin, Sima Finy, & Verona, 2013;Brown et al, 2013;Hygen et al, 2015;Hygen, Guzey, Belsky, Berg-Nielsen, & Wichstrøm, 2014); however, the GϫE field has been subjected to controversy and critique (e.g., Duncan & Keller, 2011). Nevertheless, prior research indicates that the OXTR SNP rs53576 interacts with various environmental factors in predicting diverse behavioral and psychological phenotypes.…”

Section: Gene-؋-environment Interactionmentioning

confidence: 99%

Change in parenting, change in student–teacher relationships, and oxytocin receptor gene (OXTR): Testing a gene-×-environment (G×E) hypothesis in two samples.

Hygen¹,

Belsky²,

Li³

et al. 2017

Developmental Psychology

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Prior research suggests that parenting affects children's relationships, including those with teachers, although there is variation across individuals in such effects. Given evidence suggesting that oxytocin may be particularly important for the quality of social relationships, we tested the hypotheses (a) that change in parenting from 4 to 6 years of age influences and predicts change in the student-teacher relationship from 6 to 8 years of age and (b) that this effect is moderated by a polymorphism related to the child's oxytocin receptor gene (OXTR), rs53576. In 2 studies, participants included, respectively, 652 socioeconomically diverse Norwegian children from a community sample (50.8% male; mean age of 54.9 months at first assessment) and 559 such children from 8 different U.S. locales (49.0% male; approximately 54 months at the first assessment). Norwegian results showed that change in parenting predicted change in student-teacher relationships, but only in the case of children homozygous for the A allele of rs53576 and in a manner consistent with differential-susceptibility theory: for AA carriers, when parenting changed for the worse, so did children's relationship with teachers, whereas when parenting changed for the better, the teacher-child relationships improved accordingly. Such GϫE findings could not be replicated in the American sample. Results are discussed in terms of 2 contrasting models of Person-ϫ-Environment interaction (differential susceptibility and diathesis stress) and potential reasons for failure to replicate.

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Prenatal depression and 5‐HTTLPR interact to predict dysregulation from 3 to 36 months – A differential susceptibility model

Cited by 58 publications

References 51 publications

Effects of prenatal factors and temperament on infant cortisol regulation in low‐income Mexican American families

Effects of prenatal factors and temperament on infant cortisol regulation in low‐income Mexican American families

Gene and environment interaction: Is the differential susceptibility hypothesis relevant for obesity?

Change in parenting, change in student–teacher relationships, and oxytocin receptor gene (OXTR): Testing a gene-×-environment (G×E) hypothesis in two samples.

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