Prenatal cocaine exposure alters emotional arousal regulation and its effects on working memory

Li, Zhi-Hao; Coles, Claire D.; Lynch, Mary Ellen; Hamann, Stephan; Peltier, Scott; LaConte, Stephen M.; Hu, Xiaoping

doi:10.1016/j.ntt.2009.08.005

Cited by 44 publications

(97 citation statements)

References 63 publications

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“…We found a significant association between PCE and short-term memory (Richardson et al, 2009), and other researchers have reported deficits in specific areas such as verbal reasoning/memory (Bennett et al, 2002), executive function , cognitive processing/learning (Bridgett et al, 2011;Mayes et al, 2005Mayes et al, , 2007, visual spatial/math skills (Singer et al, , 2008, visual motor integration Schroder et al, 2004), and attention, inhibitory control, and impulsivity (Accornero et al, 2007;Bandstra et al, 2001;Bendersky et al, 2003;Carmody et al, 2011;Noland et al, 2005;Rose-Jacobs et al, 2009). However, there are also reports that show no negative effects of PCE on specific areas of cognition (Betancourt et al, 2011;Eyler et al, 2009;Hurt et al, 2009;Li et al, 2009;, and most groups, including ours, do not find a relation between PCE and global cognitive development (Accornero et al, 2007;Bandstra et al, 2002;Frank et al, 2005;Hurt et al, 1997Hurt et al, , 2001Messinger et al, 2004;Morrow et al, 2004Morrow et al, , 2006Singer et al, 2004).…”

Section: Introductioncontrasting

confidence: 46%

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Effects of prenatal cocaine exposure on adolescent development

Richardson

Goldschmidt

Day

2009

Neurotoxicology and Teratology

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The associations between prenatal cocaine exposure (PCE) and adolescent behavior, cognitive development, and physical growth were examined in 219 15-year-olds who have participated in a longitudinal study since their fourth gestational month. During the first trimester, 42% of the women used cocaine, with use declining across pregnancy. At the 15-year follow-up, the caregivers were, on average, 43 years old, had 13 years of education, and 50% were African American. First trimester PCE was not associated with global cognitive development or with measures of learning and memory. First trimester PCE was significantly related to adolescentreported delinquent behavior, poorer problem solving and abstract reasoning, and reduced weight, height, and head circumference at 15 years. These results were significant after other factors that affect these domains were controlled in regression analyses. In addition, exposure to violence partially mediated the effect of PCE on delinquent behavior. These adolescent domains are important because they are predictors of poorer adult functioning.

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Section: Introductioncontrasting

confidence: 46%

“…These adolescent outcomes were not found to be affected by PCE in other reports (Betancourt et al, 2011;Li et al, 2009;Rose-Jacobs et al, 2011). However, there are few reports in the literature, so this association remains to be determined.…”

Section: Discussionmentioning

confidence: 49%

Effects of prenatal cocaine exposure on adolescent development

Richardson

Goldschmidt

Day

2009

Neurotoxicology and Teratology

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“…Sixteen studies from 7 cohorts defined cocaine exposure dichotomously: "exposed" versus "nonexposed" 18,23,24,[32][33][34][35][36][37][38][39][40][41][42][43] or "heavy/persistent" versus "some/ none." 21 Six studies from 1 cohort defined "heavy" as first trimester use $3 times per week.…”

Section: Definition Of Pcementioning

confidence: 99%

“…24,33,[38][39][40][41][42]47 All had small sample sizes (N = 34-56), used few covariates other than other prenatal drug exposures, and had different neuroimaging methods (3 used similar methods).…”

Section: Neuroimagingmentioning

confidence: 99%

Systematic Review of Prenatal Cocaine Exposure and Adolescent Development

et al. 2013

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BACKGROUND AND OBJECTIVE: Previous research found that prenatal cocaine exposure (PCE) may increase children' s vulnerability to behavior and cognition problems. Maturational changes in brain and social development make adolescence an ideal time to reexamine associations. The objective was to conduct a systematic review of published studies examining associations between PCE and adolescent development (behavior, cognition/school outcomes, physiologic responses, and brain morphology/functioning). METHODS:Articles were obtained from PubMed, PsycInfo, Web of Science, and CINAHL databases through July 2012 with search terms: prenatal drug, substance, or cocaine exposure; adolescence/adolescent; and in utero substance/drug exposure. Criteria for inclusion were nonexposed comparison group, human adolescents aged 11 to 19, peer-reviewed, English-language, and adolescent outcomes. RESULTS:Twenty-seven studies representing 9 cohorts met the criteria. Four outcome categories were identified: behavior, cognition/school performance, brain structure/function, and physiologic responses. Eleven examined behavior; 7 found small but significant differences favoring nonexposed adolescents, with small effect sizes. Eight examined cognition/school performance; 6 reported significantly lower scores on language and memory tasks among adolescents with PCE, with varying effect sizes varied. Eight examined brain structure/function and reported morphologic differences with few functional differences. Three examined physiologic responses with discordant findings. Most studies controlled for other prenatal exposures, caregiving environment, and violence exposure; few examined mechanisms.CONCLUSIONS: Consistent with findings among younger children, PCE increases the risk for small but significantly less favorable adolescent functioning. Although the clinical importance of differences is often unknown, the caregiving environment and violence exposure pose additional threats. Future research should investigate mechanisms linking PCE with adolescent functioning.

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“…The aforementioned deficits in arousal regulation associated with prenatal cocaine exposure appear to underlie brain and behavior-related working memory function. Li et al [139] showed differential patterns of activation as a function of emotionmemory interactions. Increased demands on memory load diminished emotion-related activation in the amygdala in controls but not in the exposed group.…”

Section: Working Memorymentioning

confidence: 99%

Review of Current Neuroimaging Studies of the Effects of Prenatal Drug Exposure: Brain Structure and Function

Willford¹,

Smith²,

Kuhn³

et al. 2016

Recent Advances in Drug Addiction Research and Clinical Applications

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Neuroimaging tools have provided novel methods for understanding the impact of prenatal drug exposure on brain structure and function and its relation to development and behavior. Information gained from neuroimaging studies allows for the investigation of how prenatal drug exposure alters the typical developmental trajectory. The current prevalence and characteristics of prenatal drug exposure and its implications for vulnerable periods of brain development are reviewed. Structural and functional neuroimaging methods are introduced with examples of how study results from prenatal alcohol, cocaine, marijuana, and tobacco exposure further our understanding of the neurodevelopment impact of prenatal drug exposure. Prenatal drug neuroimaging studies have advanced our understanding of mechanisms and functional deficits associated with prenatal drug exposure. Studies have identified brain circuits associated with the default mode network, inhibitory control, and working memory that show differences in function as a result of prenatal drug exposure. The information gained from studies of prenatal drug exposure on brain structure and function can be used to make connections between animal models and human studies of prenatal drug exposure, identify biomarkers of documented effects of prenatal drug exposure on behavior, and inform prevention and intervention programs for young children.

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Prenatal cocaine exposure alters emotional arousal regulation and its effects on working memory

Cited by 44 publications

References 63 publications

Effects of prenatal cocaine exposure on adolescent development

Effects of prenatal cocaine exposure on adolescent development

Systematic Review of Prenatal Cocaine Exposure and Adolescent Development

Review of Current Neuroimaging Studies of the Effects of Prenatal Drug Exposure: Brain Structure and Function

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