Prenatal arsenic exposure alters keratinocyte stem cell fate through persistent activation of IGF2R‐MAPK cascade leading to aggravated skin carcinogenesis in mice offspring
Anchal Chauhan,
Siddhartha Gangopadhyay,
Vineeta Sharma
et al.
Abstract:Chronic exposure to arsenic (As) promotes skin carcinogenesis in humans and potentially disturbs resident stem cell dynamics, particularly during maternal and early life exposure. In the present study, we demonstrate how only prenatal arsenic exposure disturbs keratinocyte stem cell (KSC) conditioning using a BALB/c mice model. Prenatal As exposure alters the normal stemness (CD34, KRT5), differentiation (Involucrin), and proliferation (PCNA) program in skin of offspring with progression of age as observed at … Show more
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