Prenatal and Postnatal Maternal Trajectories of Cigarette Use Predict Adolescent Cigarette Use

Genna, Natacha M. De; Goldschmidt, Lidush; Day, Nancy L.; Cornelius, Marie D.

doi:10.1093/ntr/ntv269

Cited by 17 publications

(17 citation statements)

References 23 publications

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“…An offspring-of-twins retrospective cohort study in the US reported an odds ratio of 1.74 (95% CI 1.18, 2.58) for regular smoking among adolescent and adult offspring (ages 12-32 years) born to mothers who smoked during pregnancy; 15 and a prospective cohort study in Australia reported an OR of 1.53 (95% CI 1.19, 1.96) for nicotine dependence or withdrawal among 21 year olds born to mothers who smoked during pregnancy. 16 As the majority of prenatal smokers continue smoking after delivery, 17 it is possible that these observed associations may be at least partly due to indirect behavioural effects (vs. direct physiological fetal effects) among children growing up with smoking vs. non-smoking mothers. However, a population-representative study using data from the US Children and Young Adults of the National Longitudinal Survey of Youth 1979 cohort examined possible indirect behavioural effects by separately assessing the risks of smoking (early initiation at 14-16 years of age; early experimentation; and late initiation at 16+ years) in children of prenatal smokers who did and did not quit smoking after delivery, relative to children of non-smoking mothers and reported similarly increased (1.6-to 2.8-fold) ORs regardless of whether maternal smoking stopped after delivery, suggesting that one pathway for intergenerational transmission of smoking via maternal prenatal smoking likely involves a direct physiological mechanism.…”

Section: Commentmentioning

confidence: 99%

Daughters of Mothers Who Smoke: A Population‐based Cohort Study of Maternal Prenatal Tobacco use and Subsequent Prenatal Smoking in Offspring

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Mueller

2016

Paediatric Perinatal Epid

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Background Prenatal exposure to tobacco is associated with adverse health outcomes for the mother and child, and has been associated with an increased risk of tobacco smoking and nicotine dependence in offspring. The objective of this study was to examine the risk of prenatal smoking, among daughters, associated with maternal prenatal smoking. Methods We used a population-based cohort study design, with linked vital records data of mothers and daughters delivering 1984–1996 and 1996–2013, respectively, in Washington State. The exposure of interest was mothers’ prenatal smoking (any versus no smoking at any time during pregnancy), while the outcome was daughters’ prenatal smoking (similarly assessed). We used multivariable log-binomial regression to obtain estimates of the relative risk (RR) and 95% confidence interval (CI). Results Daughters exposed to maternal prenatal smoking were more likely to smoke during their pregnancy, compared to unexposed daughters (RR = 1.78; 95% CI: 1.72, 1.84, adjusted for the year the daughter delivered, her marital status and educational attainment, and the mothers’ race/ethnicity). Conclusions In this relatively young population, we found that daughters exposed to maternal prenatal smoking have an increased risk of smoking later on during their own pregnancy, emphasizing the importance of exposures during the prenatal period. The mechanisms leading to prenatal smoking are multifactorial and likely include behavioral, genetic, epigenetic and environmental factors. An understanding of this risk factor for prenatal smoking may guide healthcare providers to better target smoking cessation interventions to at-risk populations.

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Section: Commentmentioning

confidence: 99%

Daughters of Mothers Who Smoke: A Population‐based Cohort Study of Maternal Prenatal Tobacco use and Subsequent Prenatal Smoking in Offspring

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Mueller

2016

Paediatric Perinatal Epid

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“…Maternal substance use is a well-known risk factor for offspring substance use and substance use disorders. This risk begins early in life, as prenatal tobacco cigarette exposure predicts cigarette use during adolescence (Agrawal et al, 2010; Cornelius et al, 2000, 2005; De Genna et al, 2016a; O’Brien & Hill, 2014) and risk for tobacco dependence (Buka et al, 2003; De Genna et al, 2017a; Shenassa et al, 2015). Similarly, maternal prenatal cannabis use is linked to cigarette and cannabis use (Porath & Fried, 2005, Sonon et al, 2015) and cannabis dependence (Sonon et al, 2016) in exposed offspring.…”

Section: Introductionmentioning

confidence: 99%

“…For example, trajectories of cannabis use in teenage mothers predicted early initiation of sexual intercourse in adolescent offspring, suggesting that maternal substance use may play a role in the inter-generational transfer of risk for early parenthood (De Genna et al, 2015b). Trajectory analyses of maternal tobacco cigarette use have revealed the utility of examining long-term patterns of maternal substance use as risk factors for cigarette use in offspring (De Genna et al, 2016a; Melchior et al, 2010). It is important to investigate the effects of maternal patterns of co-use of cannabis and tobacco on offspring co-use and drug use disorders, controlling for variables that are associated with substance use in both mother and child.…”

Section: Introductionmentioning

confidence: 99%

Trajectories of pre- and postnatal co-use of cannabis and tobacco predict co-use and drug use disorders in adult offspring

Genna

Goldschmidt

Richardson

et al. 2018

Neurotoxicology and Teratology

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Co-use of cannabis and tobacco is increasingly common among women and is associated with tobacco and cannabis dependence and poorer cessation outcomes. However, no study has examined maternal patterns of co-use over time, or the impact of maternal co-use on co-use and drug problems in adult offspring. Pregnant women (M age = 23, range = 18-42; 52% African American, 48% White) were asked about substance use during each trimester of pregnancy, and at 8 and 18 months, 3, 6, 10, 14, 16, and 22 years postpartum. We examined patterns of any maternal cigarette and cannabis use during pregnancy and the postpartum years. As young adults (M age = 22.8 years, range = 21-26), 603 offspring completed the Diagnostic Interview Schedule (DIS). Growth mixture modeling (GMM) was used to identify four maternal trajectories through 16 years postpartum: (1) no co-use (66%), (2) decreasing co-use (16%), (3) postpartum-only co-use (11%), and (4) chronic co-use (7%). Offspring whose mothers were in the decreasing co-use group (co-users primarily during prenatal and preschool periods) were more likely to be co-users than the offspring of non-co-users. Offspring whose mothers were chronic co-users of cigarettes and cannabis were more than twice as likely to have a drug use disorder than young adults whose mothers were not co-users. The results of this study highlight the heterogeneity in maternal co-use of tobacco and cannabis over time, with some women quitting during pregnancy but resuming co-use in the postpartum, and other women co-using during pregnancy but desisting co-use over time. Maternal trajectories of co-use were associated with inter-generational transfer of risk for substance use and dependence in adult offspring.

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“…Prenatal smoking has been associated with multiple hazards to the developing fetus, 1 including but not limited to increased risk of low birth weight, 2 premature birth, 3 cognitive development, 4 respiratory health, 5,6 congenital gastrointestinal disorders, 7 higher risk of smoking during adolescence, 8 and potential neurodevelopmental disorders. [9][10][11] Despite these risks, it is estimated that one in ten pregnant women in the United States smoke cigarettes.…”

Section: Introductionmentioning

confidence: 99%

Serious Psychological Distress and Smoking During Pregnancy in the United States: 2008–2014

Goodwin

Cheslack‐Postava

Nelson

et al. 2017

Nicotine &Amp; Tobacco Research

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SPD and smoking in pregnancy are robustly linked; the prevalence of smoking in pregnancy is extremely high in women with SPD. Screening women with mental health problems for prenatal smoking, as well as screening pregnant smokers for mental health problems, seems warranted and may assist more women in seeking and utilizing treatment options. Efforts to reduce the prevalence of smoking during pregnancy might specifically target women with SPD, where the potential for impact is substantial.

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Prenatal and Postnatal Maternal Trajectories of Cigarette Use Predict Adolescent Cigarette Use

Cited by 17 publications

References 23 publications

Daughters of Mothers Who Smoke: A Population‐based Cohort Study of Maternal Prenatal Tobacco use and Subsequent Prenatal Smoking in Offspring

Daughters of Mothers Who Smoke: A Population‐based Cohort Study of Maternal Prenatal Tobacco use and Subsequent Prenatal Smoking in Offspring

Trajectories of pre- and postnatal co-use of cannabis and tobacco predict co-use and drug use disorders in adult offspring

Serious Psychological Distress and Smoking During Pregnancy in the United States: 2008–2014

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