Prenatal and Postnatal Management of Congenital Pulmonary Airway Malformation

David, Mafalda; Lamas-Pinheiro, Rúben; Henriques‐Coelho, Tiago

doi:10.1159/000440894

Cited by 95 publications

(123 citation statements)

References 142 publications

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“…It was first described by Ch’In and Tang in 1949 [1]. It is a hamartomatous, dysplastic developmental abnormality of the lung characterized by abnormal airway patterning during lung branching morphogenesis and is formed by abnormal branching of the immature bronchioles [2,3].…”

Section: Discussionmentioning

confidence: 99%

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An Atypical Presentation of Congenital Pulmonary Airway Malformation (CPAM): A Rare Case with Antenatal Ultrasound Findings and Review of Literature

Sm²,

et al. 2018

Pol J Radiol

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SummaryBackgroundCongenital pulmonary airway malformation (CPAM) is a relatively rare congenital anomaly with a wide spectrum of ultrasound features depending on the specific variety of CPAM. Antenatal ultrasound is a valuable, safe, nonionizing, cost-effective, widely available and easily reproducible imaging tool and is indispensable in the diagnosis of CPAM. In this paper, we aimed to report an atypical imaging presentation of CPAM type II in the second trimester, extensively involving all lobes of the left lung.Case ReportA 25-year-old G1P0A0 woman with a gestational age of around 22 weeks was referred for an anomaly scan. The antenatal ultrasound scan showed a single, live, intrauterine foetus corresponding to a gestational age of around 22 weeks and 4 days. There were multiple, anechoic structures noted within the pulmonary tissue in the left hemithorax, each measuring around 3 to 4 mm in diameter. The lesion was extending from the left lower lobe up to the apical (apicoposterior) segment of the left upper lobe. The ultrasound diagnosis of congenital pulmonary airway malformation type II was made. After explaining the condition and the poor prognosis to the patient, an informed consent was obtained after she opted for medical termination of pregnancy.ConclusionsCongenital pulmonary airway malformation (CPAM) is an uncommon foetal anomaly with a very wide range of ultrasound appearances depending on the specific type of CPAM. CPAM also has a wide spectrum of differential diagnoses and a variable prognosis. Antenatal ultrasound should always be the primary mode of diagnosis in CPAM.

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Section: Discussionmentioning

confidence: 99%

“…In 2001, Bush proposed a classification based on histologic differences and named cystic, intermediate and solid congenital thoracic malformations. In 2003, Langston classified cystic lung lesions based on pathologic features due to airway obstruction during development into a large cyst-type lesions and a small cyst-type lesions [1]. …”

Section: Discussionmentioning

confidence: 99%

An Atypical Presentation of Congenital Pulmonary Airway Malformation (CPAM): A Rare Case with Antenatal Ultrasound Findings and Review of Literature

Sm²,

et al. 2018

Pol J Radiol

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“…The timing of regression is variable but tends to be in the mid-third trimester usually at 32034 weeks of gestation. 8 Hydrops is the strongest prognostic factor and it may be an indication for prenatal intervention. A Survival rate is more than 95% in CCAMs without hydrops.…”

Section: Classification Of Ccamsmentioning

confidence: 99%

Congenital cystic adenomatoid malformation (CCAM): antenatal and postnatal management

Kanavi

Thangaraj

Thomas

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Congenital cystic adenomatoid malformation (CCAM) is a rare abnormality of lung development. The estimated incidence ranges from 1: 10,000 to 1.35,000 live births. It is diagnosed by prenatal screening at 18-20 weeks of gestation. Surgical excision of symptomatic lesions is relatively straight forward, but management of asymptomatic lesions is controversial. Methods: Among women who delivered at St. Johns medical college and hospital, Bangalore between Jan 2011 to Dec 2016, those with the diagnosis of CCAM during anomaly scan were included in the study. Antenatal and Postnatal period and their outcomes were evaluated. Follow up was extend up to the childhood in the affected foetus. Results: There were 5 cases of CCAM in 13057 deliveries during 5-year study. Incidence was 1:2611. Mean gestational age at diagnosis was 21.6±2.5weeks. All foetus had CVR (CCAM volume) ratio more than 1.6 and there was no compromise on lung volume. Mean lung volume was 62.8±8.6 cc. and mean Apgar score at 1minute was 6.8±2.7 and at 5 minutes was 8.0±2.2. Among 5 foetuses, 2 foetuses had regression of cyst by birth and 3 underwent surgery for resection after birth. Conclusions: CCAM remains a challenge for obstetricians, neonatologists and paediatric surgeons. The combination of prenatal MRI and serial ultrasound studies optimize foetal surveillance and postnatal care. In asymptomatic CCAM, babies should be followed up to adolescence and adulthood, as they can manifest with malignant changes.

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“…This letter is written to hopefully interject a note of clarity regarding the relationship of congenital pulmonary airway malformation type IV (CPAM IV) and type I pleuropulmonary blastoma (PPB I), a subject which is considered in the recent review on the management of CPAM by David et al [1]. One can easily gain the impression that CPAM IV and PPB I are distinctly different lesions, but the authors recognize that there is some relationship between them.…”

mentioning

confidence: 99%

Type I Pleuropulmonary Blastoma versus Congenital Pulmonary Airway Malformation Type IV

et al. 2016

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Prenatal and Postnatal Management of Congenital Pulmonary Airway Malformation

Cited by 95 publications

References 142 publications

An Atypical Presentation of Congenital Pulmonary Airway Malformation (CPAM): A Rare Case with Antenatal Ultrasound Findings and Review of Literature

An Atypical Presentation of Congenital Pulmonary Airway Malformation (CPAM): A Rare Case with Antenatal Ultrasound Findings and Review of Literature

Congenital cystic adenomatoid malformation (CCAM): antenatal and postnatal management

Type I Pleuropulmonary Blastoma versus Congenital Pulmonary Airway Malformation Type IV

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