Prenatal and postnatal exposure to organophosphate pesticides and childhood neurodevelopment in Shandong, China

Wang, Yiwen; Zhang, Yan; Ji, Lin; Hu, Yi; Zhang, Jingjing; Wang, Cai‐Feng; Ding, Guodong; Chen, Limei; Kamijima, Michihiro; Ueyama, Jun; Gao, Yu; Tian, Ying

doi:10.1016/j.envint.2017.08.010

Cited by 77 publications

(35 citation statements)

References 41 publications

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“…One urine blank and 4 urine spikes (2 duplicate samples for high and low concentrations) were included at every 38 urine samples. The percent of relative standard deviation (% RSD) for DAP metabolites ranged from 0.5% to 6.3% for the within-run precision, and from 3.0% to 17.8% for the between-run precision, as described elsewhere (Wang et al 2017b). Metabolite concentrations were normalized to creatinine (Cr) concentrations in urine to correct for variable urine dilutions in the spot urine samples analyses.…”

Section: Environmental Health Perspectivesmentioning

confidence: 99%

“…Our previous studies documented that exposure to OP was associated with prolonged time of pregnancy, decreased length of gestation, and poorer intellectual development in offspring (Hu et al 2018;Wang et al 2012;Wang et al 2017b). Most studies examining the relationship between OP exposure and adverse reproductive outcomes have primarily focused on women who conceived naturally (Levario-Carrillo et al 2004;Pastore et al 1997;Zhu et al 2006;Hu et al 2018;Wang et al 2012;Wang et al 2017b). The evidence of adverse associations between OP and endocrine function raised further concerns about chronic OP exposures and potential effects on pregnancy outcomes in women undergoing IVF.…”

Section: Introductionmentioning

confidence: 99%

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Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Vinturache

et al. 2020

Environ Health Perspect

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BACKGROUND: Animal studies suggest that pesticide exposure elicits endocrine changes, increases embryo implantation failure, and decreases litter size. However, only a few epidemiological studies have evaluated the effects of pesticides on the outcomes of in vitro fertilization (IVF) pregnancies. OBJECTIVES: This study examined the associations between preconception organophosphate pesticides (OP) exposure and pregnancy outcomes among women undergoing IVF in a Chinese population. METHODS: This study included 522 women with infertility who underwent IVF. Women were recruited from a prospective study, the China National Birth Cohort (CNBC), from Shanghai, China, between July 2017 and December 2018. Demographic and clinical information were collected from medical records and through questionnaires. Preconception exposure to OP was assessed by measuring six nonspecific dialkylphosphate (DAP) metabolites [diethylthiophosphate (DETP), diethylphosphate (DEP), diethyldithiophosphate (DEDTP), dimethylthiophosphate (DMTP), dimethylphosphate (DMP), dimethyldithiophosphate (DMDTP)] in urine samples collected at recruitment. Generalized estimating equation (GEE) models were used to evaluate the associations between OP and pregnancy outcomes. RESULTS: Compared with women in the lowest quartile (Q 1) of individual DEP and R 4 DAP (the sum of DMP, DMTP, DEP, and DETP), women in the highest quartile (Q 4) had lower odds of successful implantation, clinical pregnancy, and live birth, and most of the negative trends were significant (p-trends <0:05). There were no significant associations between urinary DAP concentrations and early IVF outcomes, including total and mature oocyte counts, best embryo quality, fertilization, E 2 trigger levels, and endometrial wall thickness. CONCLUSION: Preconception OP exposure was inversely associated with successful implantation, clinical pregnancy, and live birth in women who underwent IVF.

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Section: Environmental Health Perspectivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Vinturache

et al. 2020

Environ Health Perspect

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“…79 Low doses of acephate induced nitric oxide synthase overexpression in the hypothalamus of mice, 80 while pre-and postnatal exposure to organophosphates impaired neurodevelopment in young humans, and boys seem to be more susceptible to these effects than girls at the same age. 81 Sexual differences have been observed in other studies with environmental pollutants that are endocrine disruptors. Ilagan et al have reported sexual dimorphism in the gene expression of the liver after exposure to BPA in utero; such changes persisted into adulthood.…”

Section: Environment Pollutants Neural Plasticity and Dohadmentioning

confidence: 74%

Environmental monitoring and the developmental origins of health and disease

Almeida

Pavanello

Saavedra

et al. 2019

J Dev Orig Health Dis

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Early-life chronic exposure to environmental contaminants, such as bisphenol-A, particulate matter air pollution, organophosphorus pesticides, and pharmaceutical drugs, among others, may affect central tissues, such as the hypothalamus, and peripheral tissues, such as the endocrine pancreas, causing inflammation and apoptosis with severe implications to the metabolism. The Developmental Origins of Health and Disease (DOHaD) concept articulates events in developmental phases of life, such as intrauterine, lactation, and adolescence, to later-life metabolism and health. These developmental phases are more susceptible to environmental changes, such as those caused by environmental contaminants, which may predispose individuals to obesity, metabolic syndrome, and chronic noncommunicable diseases later in life. Alterations in the epigenome are explored as an underlying mechanism to the programming effects on metabolism, as the expression of key genes related with central and peripheral metabolic functions may be altered in response to environmental disturbances. Studies show that environmental contaminants may affect gene expressions in mammals, especially when exposed to during the developmental phases of life, leading to metabolic disorders in adulthood. In this review, we discuss the current obesity epidemics, the DOHaD concept, pollutants’ toxicology, environmental control, and the role of environmental contaminants in the central and peripheral programming of obesity and metabolic syndrome. Improving environmental monitoring may directly affect the quality of life of the population and help protect the future generations from metabolic diseases.

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“…The postnatal exposure to cypermethrin leads to neurodegenerative effects on human and rat [22], so the aim of this work was to study for the first time, the effect of prenatal exposure to cypermethrin on the development of the sensory retina and the possible role of N-acetylcysteine. The sensory retina of 7 days old postnatal rats from mothers treated with cypermethrin (CYP group) showed vacuolations of inner and outer plexiform layers.…”

Section: Discussionmentioning

confidence: 99%

The effect of N-acetylcysteine on the sensory retina of male albino rats exposed prenatally to cypermethrin

Issa

Al-Gholam

2021

Folia Morphol

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Cypermethrin (CYP), a pyrethroid that is globally used in the field and house to fight the pests. CYP can induce cellular toxicity and cross the placental barrier. N-acetylcysteine (NAC) can fight the prenatal exposure to the inflammation. This work aimed to study, for the first time, the effects of NAC on the sensory retina of male albino rats exposed prenatally to cypermethrin. Twenty four sexually mature female albino rats and twelve male albino rats were allowed for mating and divided equally into the following groups: Group I (Control Group): kept without treatment. Group II (NAC group): received 1g/kg/day NAC diluted in distilled water orally by gastric tube from the seventh day of gestation till delivery. Group III (CYP group): received 12 mg/kg/day of cypermethrin orally by gastric tube from the seventh day of gestation till delivery. Group IV (CYP and NAC group): received 12 mg/kg/day of cypermethrin and 1g/kg/day of NAC. The ten male offsprings of each group were divided into subgroups (a) and (b) that were sacrificed at the age of 7th and 14th days postnatal respectively. At the end of the experiment, the eye samples were subjected to histological, immunohistochemical and morphometric studies. Concerning the different previous studies, the sensory retina of CYP subgroups showed vacuolation of the inner and outer plexiform layers, dilated congested blood vessels, hyalinization and disorganization of the photoreceptor layer. Also, the expression of collagen IV and caspase 3 (a marker of apoptosis) was up-regulated in the CYP subgroups. NAC significantly protected the sensory retina from the damaging effects of CYP. NAC could be considered as a good protective agent against the damaging effect of CYP on the sensory retina.

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Prenatal and postnatal exposure to organophosphate pesticides and childhood neurodevelopment in Shandong, China

Cited by 77 publications

References 41 publications

Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Environmental monitoring and the developmental origins of health and disease

The effect of N-acetylcysteine on the sensory retina of male albino rats exposed prenatally to cypermethrin

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