Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder: a pooled analysis of seven European birth cohort studies

Forns, Joan; Stigum, Hein; Høyer, Birgit Bjerre; Sioen, Isabelle; Šovčíková, Eva; Nowack, Nikola; Lopez-Espinosa, Maria-José; Guxens, Mònica; Ibarluzea, Jesús; Torrent, Matías; Wittsiepe, Jürgen; Govarts, Eva; Trnovec, T.; Toft, Gunnar; Vrijheid, Martine; Iszatt, Nina; Eggesbø, Merete

doi:10.1093/ije/dyy052

Cited by 32 publications

(17 citation statements)

References 51 publications

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“…As noted above, the SDQ might not be sufficiently sensitive to specific behavioral ADHD-related problems. However, a lack of significant association with ADHD (defined based on a diagnosis reported in population-based registries or via questionnaires, including the SDQ and CBCL) was also reported in another study (Forns et al, 2018), in which the authors did not observe any significant association between either pre-or postnatal exposure (up to 24 months) to p,p′-DDE or hexachlorobenzene (HCB) and a diagnosis of ADHD, after adjusting for a number of variables (see Table 1). However, only one of the cohorts used relied on a specialist diagnosis recorded in population-based registries.…”

Section: Adhdmentioning

confidence: 77%

Association Between Exposure to Pesticides and ADHD or Autism Spectrum Disorder: A Systematic Review of the Literature

et al. 2020

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Objective: To conduct a systematic review of studies assessing the relationship between exposure to pesticides and ADHD or Autism Spectrum Disorder (ASD). Methods: Based on a pre-registered protocol in PROPSERO (CRD42018107847), we searched PubMed, Ovid databases, and ISI Web of Knowledge with no date/language/document type restrictions, up to May 2019. The Newcastle Ottawa Scale was used to assess study quality. Results: Among the 29 retained studies, 13 focused on ADHD, 14 on ASD, and two on both disorders. Ten studies reported a significant association between exposure to pesticides and ADHD/ADHD symptoms and 12 studies found a significant association with ASD/ASD traits. The strengths of the association and the possible confounders controlled for varied substantially across studies. Conclusion: Whilst there is some evidence suggesting a possible link between pesticides and ADHD/ASD, heterogeneity across studies prevents firm conclusions. We provide methodological indications for future studies.

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Section: Adhdmentioning

confidence: 77%

Association Between Exposure to Pesticides and ADHD or Autism Spectrum Disorder: A Systematic Review of the Literature

et al. 2020

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“…While there will be variability in exposure levels due to trends in exposure over time or regulatory policies, the ability to describe these temporal trends is a strength of the ECHO Program given that participant birth years span the early 1980s through present day. Overall, harmonization challenges can be overcome through thoughtful study design and statistical methods, as has been demonstrated in previous pooled studies of chemical exposures in US [ 232 – 234 ] and European [ 235 – 237 ] cohorts.…”

Section: Discussionmentioning

confidence: 99%

Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program

Buckley

Barrett

Beamer

et al. 2020

J Expo Sci Environ Epidemiol

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The Environmental Influences on Child Health Outcomes (ECHO) Program will evaluate environmental factors affecting children’s health (perinatal, neurodevelopmental, obesity, respiratory, and positive health outcomes) by pooling cohorts composed of >50,000 children in the largest US study of its kind. Our objective was to identify opportunities for studying chemicals and child health using existing or future ECHO chemical exposure data. We described chemical-related information collected by ECHO cohorts and reviewed ECHO-relevant literature on exposure routes, sources, and environmental and human monitoring. Fifty-six ECHO cohorts have existing or planned chemical biomonitoring data for mothers or children. Environmental phenols/parabens, phthalates, metals/metalloids, and tobacco biomarkers are each being measured by ≥15 cohorts, predominantly during pregnancy and childhood, indicating ample opportunities to study child health outcomes. Cohorts are collecting questionnaire data on multiple exposure sources and conducting environmental monitoring including air, dust, and water sample collection that could be used for exposure assessment studies. To supplement existing chemical data, we recommend biomonitoring of emerging chemicals, non-targeted analysis to identify novel chemicals, and expanded measurement of chemicals in alternative biological matrices and dust samples. ECHO’s rich data and samples represent an unprecedented opportunity to accelerate environmental chemical research to improve the health of US children.

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“…Depuis les années 2000, les études de cohortes et cas-témoins (Tableau 2) menées aux Etats-Unis, Japon, et Europe indiquent qu'une exposition prénatale aux PCB (PCB-DL, PCB-NDL, différents congénères) est associée à diverses altérations du neurodéveloppement chez les jeunes enfants et les enfants d'âge scolaire (7,8,(26)(27)(28)(29)(30)(31)(32)(33). Il s'agit d'altérations cognitives (concentration, attention, mémoire de travail verbale, visuelle, auditive), sensorimotrices, comportementales (impulsivité).…”

Section: Données éPidémiologiquesunclassified

Ubiquitous environmental pollutants and neurodevelopment

Etiemble¹,

Cordier²

2022

Environnement Risques Santé

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Des études épidémiologiques longitudinales menées dans différents pays ont évalué les associations entre l'exposition actuelle à des polluants qui sont, ou ont été, très présents dans l'environnement comme le plomb, les polychlorobiphényles (PCB), les dioxines, la pollution atmosphérique et le neurodéveloppement de l'enfant. Ces études de cohorte mère-enfant ou d'enfants décrivent des associations de l'exposition prénatale ou la première année de vie avec des perturbations du développement mental et psychomoteur chez le jeune enfant ainsi que des déficits cognitifs ou des altérations comportementales chez l'enfant plus âgé. L'impact de ces expositions sur le risque de troubles du neurodéveloppement (TND) tels que le trouble déficit d'attention/hyperactivité (TDAH) ou les troubles du spectre autistique (TSA) est également suggéré en particulier avec l'exposition prénatale au plomb pour le TDAH, à la pollution atmosphérique (particules fines) pour le TSA. Les études expérimentales montrent divers modes d'action de ces polluants et leurs mécanismes au niveau moléculaire et cellulaire : stress oxydant, perturbations neuroendocrines et des neurotransmissions, neuroinflammation, ainsi que des modifications épigénétiques qui peuvent altérer le développement cérébral pendant la période embryonnaire et foetale et l'acquisition des compétences cognitives et comportementales pendant l'enfance.

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Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder: a pooled analysis of seven European birth cohort studies

Abstract: In the largest study to date of 4437 children in seven European birth cohorts, we did not observe any association between either pre- or postnatal exposure (up to 24 months) to PCB-153, p-p´-DDE and HCB and the risk of ADHD before the age of 10 years.

Cited by 32 publications

References 51 publications

Association Between Exposure to Pesticides and ADHD or Autism Spectrum Disorder: A Systematic Review of the Literature

Association Between Exposure to Pesticides and ADHD or Autism Spectrum Disorder: A Systematic Review of the Literature

Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program

Ubiquitous environmental pollutants and neurodevelopment

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