Prenatal and Postnatal Development after Transitory Gestational Zinc Deficiency in Rats

Hurley, Lucille S.; Mutch, Patricia B.

doi:10.1093/jn/103.5.649

Cited by 79 publications

(24 citation statements)

References 12 publications

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“…zinc (8,9). Zinc deficiency in pregnant rats quickly produces anorexia and, in the fetus a high incidence of congenital malformations, decreased amount of DNA in brain and liver, decreased total body and liver zinc as well as intrauterine growth retarda tion (10,11). A decreased metabolism of ethanol and retinol has also been reported in zinc-deficient rats (12).…”

Section: Introductionmentioning

confidence: 99%

Effect of a Dietary Rapeseed Protein Concentrate on the Contents of α-Tocopherol and Zinc in Serum, Liver and Tibia of Rats

Eklúnd

Ågren²

1978

Ann Nutr Metab

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In order to study the effects of a dietary rapeseed protein concentrate (RPC) on tocopherol and zinc levels in serum, liver and tibia, female rats were fed a tocopherol-reduced diet for a 3-week period and were then transferred to either of a RPC diet or a control diet containing casein at 20% levels of protein. No unfavourable effects on food intakes or weight gains were recorded. The serum zinc content of the RPC group was slightly reduced and the serum tocopherol values significantly lowered in comparison to the control group. Zinc and tocopherol contents of the livers were not changed. Precipitation of sera by dextran sulphate in the presence of calcium ions indicated a reduced level of low density lipoproteins in rats fed RPC diet. In a second experiment, male and female rats were fed diets containing 10% of protein derived either from RPC or casein. Low zinc contents of tibiae indicated a low biological availability of the zinc present in the RPC diet. Rats on RPC diet also showed reduced levels of tocopherol in serum. Despite a lowered zinc status in rats fed RPC diet there was no reduction in food intake, weight gain or growth of tibia in these groups.

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Section: Introductionmentioning

confidence: 99%

Effect of a Dietary Rapeseed Protein Concentrate on the Contents of α-Tocopherol and Zinc in Serum, Liver and Tibia of Rats

Eklúnd

Ågren²

1978

Ann Nutr Metab

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“…As a consequence, Zn is critical for many physiological processes such as immune function (11), reproduction (1,17), and growth (18). Approximately 1-3 mg Zn is transferred from the mammary gland into milk each day to provide optimal Zn nutriture for the developing infant (34).…”

mentioning

confidence: 99%

ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells

McCormick

Kelleher

2012

American Journal of Physiology-Cell Physiology

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McCormick NH, Kelleher SL. ZnT4 provides zinc to zincdependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells. Am J Physiol Cell Physiol 303: C291-C297, 2012. First published May 23, 2012 doi:10.1152/ajpcell.00443.2011 transporter 4 (ZnT4) plays a key role in mammary gland Zn metabolism. A mutation in ZnT4 (SLC30A4) that targets the protein for degradation is responsible for the "lethal milk" (lm/lm) mouse phenotype. ZnT4 protein is only detected in the secreting mammary gland, and lm/lm mice have ϳ35% less Zn in milk, decreased mammary gland size, and decreased milk secretion. However, the precise contribution of ZnT4 is unknown. We used cultured mouse mammary epithelial cells (HC11) and determined that ZnT4 was localized to the trans-Golgi network (TGN) and cell membrane and transported Zn from the cytoplasm. ZnT4-mediated Zn import into the TGN directly contributed to labile Zn accumulation as ZnT4 overexpression increased FluoZin3 fluorescence. Moreover, ZnT4 provided Zn for metallation of galactosyltransferase, a Zn-dependent protein localized within the TGN that is critical for milk secretion, and carbonic anhydrase VI, a Zn-dependent protein secreted from the TGN into milk. We further noted that ZnT4 relocalized to the cell membrane in response to Zn. Together these studies demonstrated that ZnT4 transports Zn into the TGN, which is critical for key secretory functions of the mammary cell.

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“…Higher Zn levels in full-term fetal plasma than in maternal plasma has also been reported in rats (Hurley and Mutch 1973) and in sheep and goats (Lichti et al 1970 (Kalinowski and Chavez 1985).…”

Section: L)mentioning

confidence: 75%

Low Dietary Zinc Intake During Pregnancy and Lactation of Gilts. Ii. Effects on the Offspring

Kalinowski¹,

Chávez²

1986

Can. J. Anim. Sci.

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Prenatal and Postnatal Development after Transitory Gestational Zinc Deficiency in Rats

Cited by 79 publications

References 12 publications

Effect of a Dietary Rapeseed Protein Concentrate on the Contents of α-Tocopherol and Zinc in Serum, Liver and Tibia of Rats

Effect of a Dietary Rapeseed Protein Concentrate on the Contents of α-Tocopherol and Zinc in Serum, Liver and Tibia of Rats

ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells

Low Dietary Zinc Intake During Pregnancy and Lactation of Gilts. Ii. Effects on the Offspring

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