Prenatal and early life exposure to air pollution and the incidence of Kawasaki disease

Kuo, Ni-Chun; Lin, Chien‐Heng; Lin, Ming-Chih

doi:10.1038/s41598-022-07081-y

Cited by 14 publications

(10 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The strongest risk related to carbon monoxide (parts per million) is during pregnancy (OR, 1.67 (95% CI, 1.23–2.28]; P =0.001) and after delivery (1.61 [95% CI, 1.16–2.22]; P =0.004). 177…”

Section: Congenital Cardiovascular Defects and Kawasaki Diseasementioning

confidence: 99%

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Martin,

Aday,

Almarzooq

et al. 2024

Circulation

View full text Add to dashboard Cite

BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health. The AHA Heart Disease and Stroke Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, brain health, complications of pregnancy, kidney disease, congenital heart disease, rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary heart disease, cardiomyopathy, heart failure, valvular disease, venous thromboembolism, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2024 AHA Statistical Update is the product of a full year’s worth of effort in 2023 by dedicated volunteer clinicians and scientists, committed government professionals, and AHA staff members. The AHA strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional global data, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

show abstract

Section: Congenital Cardiovascular Defects and Kawasaki Diseasementioning

confidence: 99%

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Martin,

Aday,

Almarzooq

et al. 2024

Circulation

View full text Add to dashboard Cite

show abstract

“…A genetic influence on arsenic metabolism is indicated by the substantial interethnic heterogeneity and familial relationships in urine arsenic (Figure 2) [36]. Source: [37].…”

Section: Effects Of Aromatic Hydrocarbon Pollution On the Endocrine A...mentioning

confidence: 99%

Effects of Pollution on Pregnancy and Infants

Rani¹,

Dhok²

2023

Cureus

View full text Add to dashboard Cite

The fetus is particularly susceptible to environmental contaminants as it is developing at the time of pregnancy and is, therefore, more susceptible to their effects. Pregnancy loss, which includes stillbirth and spontaneous abortion (miscarriage), preterm labor and delivery, and neonatal death, is the worst pregnancy outcome. Stunting and its related health and developmental effects are particularly common in populations living in underdeveloped countries or those exposed to high levels of particle pollution. Several environmental toxins can affect an embryo, fetus, or infant as they are developing. This study explores the following questions: What part do pesticides, heavy metals, dioxin derivatives, and polychlorinated diphenyl compounds play as macroenvironmental pollutants in mutagenesis and teratogenesis? What effects do substances that exposed persons have considerable control over, such as alcohol, narcotics, and tobacco smoke, have on the microenvironment? What consequences should practitioners be aware of these toxins in terms of ethics and the law? This study seeks to assess pertinent primary scientific studies on how pollution affects the health of the fetus and newborn during pregnancy.

show abstract

“…9 Oxidative stress plays a critical role in the development of KD in conjunction with inflammation. [10][11][12] Environmental pollutants induce oxidative stress by upregulating reactive oxygen species (ROS) levels. Elevated ROS result in the oxidation of low-density lipoprotein (LDL), generating DAMPs.…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress plays a critical role in the development of KD in conjunction with inflammation 10–12 . Environmental pollutants induce oxidative stress by upregulating reactive oxygen species (ROS) levels.…”

Section: Introductionmentioning

confidence: 99%

CD14 down‐modulation as a real‐time biomarker in Kawasaki disease

Inada,

Sonoda,

Mizuno

et al. 2023

Clin & Trans Imm

View full text Add to dashboard Cite

ObjectivesThe objectives of this study were to investigate the pathophysiology of Kawasaki disease (KD) from immunological and oxidative stress perspectives, and to identify real‐time biomarkers linked to innate immunity and oxidative stress in KD.MethodsWe prospectively enrolled 85 patients with KD and 135 patients with diverse conditions including immune, infectious and non‐infectious diseases for this investigation. Flow cytometry was used to analyse the surface expression of CD14, CD38 and CD62L on monocytes, along with a quantitative assessment of CD14 down‐modulation. Additionally, oxidative stress levels were evaluated using derivatives of reactive oxygen metabolites (d‐ROMs) and antioxidant capacity measured by a free radical elective evaluator system.ResultsDuring the acute phase of KD, we observed a prominent CD14 down‐modulation on monocytes, reflecting the indirect detection of circulating innate immune molecular patterns. Moreover, patients with KD showed a significantly higher CD14 down‐modulation compared with infectious and non‐infectious disease controls. Notably, the surface expression of CD14 on monocytes was restored concurrently with responses to intravenous immunoglobulin and infliximab treatment in KD. Furthermore, d‐ROM levels in patients with KD were significantly elevated compared with patients with infectious and non‐infectious diseases. Following intravenous immunoglobulin treatment, oxidative stress levels decreased in patients with KD.ConclusionMonitoring CD14 down‐modulation on monocytes in real‐time is a valuable strategy for assessing treatment response, distinguishing KD relapse from concomitant infections and selecting second‐line therapy after IVIG treatment in KD patients. The interplay between inflammation and oxidative stress likely plays a crucial role in the development of KD.

show abstract

Prenatal and early life exposure to air pollution and the incidence of Kawasaki disease

Cited by 14 publications

References 40 publications

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Effects of Pollution on Pregnancy and Infants

CD14 down‐modulation as a real‐time biomarker in Kawasaki disease

Contact Info

Product

Resources

About