Prenatal and early childhood exposure to phthalates and childhood behavior at age 7 years

Daniel, Sharon; Balalian, Arin A.; Insel, Beverly J.; Liu, Xinhua; Whyatt, Robin M.; Calafat, Antònia M.; Rauh, Virginia; Perera, Frederica P.; Hoepner, Lori; Herbstman, Julie B.; Factor-Litvak, Pam

doi:10.1016/j.envint.2020.105894

Cited by 42 publications

(34 citation statements)

References 90 publications

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“…Regarding phthalate metabolite urine concentrations measured in our population, only MIbP levels were lower than the LOD in 25.5% of samples, possibly reflecting a lower exposure if compared to other chemicals. MEP, MEHHP, MBzP and MEHP were detectable, and overall, the GM we calculated appeared in the same order of magnitude of urinary amounts of the National Health and Nutrition Examination Survey study (NHANES), including data from the non-pregnant population of women aged 18-40, except for MEP level, which was lower in our participants (GM: 22.52 µg/L and GM: 152.9 µg/L, present study and NHANES, respectively) [64]. Even considering populations not limited to childbearing age (e.g., general population or pregnant women), concentrations of phthalate metabolites in the present cohort were overlapping data from previous studies conducted worldwide [57][58][59][60][61][62][63], supporting the ubiquitous exposure to those compounds (Table S1, Supplementary Materials).…”

Section: Discussionsupporting

confidence: 70%

Lifestyle Habits and Exposure to BPA and Phthalates in Women of Childbearing Age from Northern Italy: A Pilot Study

Napoli

Tagliaferri

Sommella

et al. 2021

IJERPH

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Background: Endocrine-disrupting chemicals (EDCs) are compounds that interfere with aspects of hormonal signaling. Considerable attention has been paid to their biological effects especially in women of childbearing age or during pregnancy as EDCs have been reported to cross the placenta becoming concentrated in the fetus’ circulation. Lifestyle habits, daily consumption of packaged foods and use of healthcare/cosmetic products are associated with increased EDCs levels. This cross-sectional research examined the EDCs levels and the lifestyle determinants of EDC exposure in a cohort of reproductive-age women from Northern Italy. Methods: Forty-five women (median age: 36, IQR: 30–38) were evaluated for urinary bisphenol A (BPA) and phthalates levels and also studied for EDCs’ major determinants of daily exposure; food frequency/dietary, physical activity, smoking habits and weight status. Results: Although 100% of women seemed to have been exposed to common sources of EDCs, they reported a healthy lifestyle. The multivariable model described a positive and significant association between consumption of sauces/dressings in plastic containers and monoethyl phthalate exposure (p = 0.037). Conclusions: Since reproductive age encompasses a critical window for future health and functioning of the “mothers-to-be” and their children, future studies on prenatal dietary BPA and phthalate exposure and the role of consumer product choices in reducing such exposure are recommended.

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Section: Discussionsupporting

confidence: 70%

Lifestyle Habits and Exposure to BPA and Phthalates in Women of Childbearing Age from Northern Italy: A Pilot Study

Napoli

Tagliaferri

Sommella

et al. 2021

IJERPH

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“…A study of urban children in the US reported a sex-specific association between maternal urinary MCPP and metabolites of DBP and lower mental development index (MDI) among girls. However, the opposite association was observed among boys [50]. Similarly, prenatal exposure to DBP and BBzP was significantly associated with language delay in children in the US and Sweden [53].…”

Section: Phthalates and Neurodevelopmentmentioning

confidence: 84%

“…A fair number of longitudinal studies were found, and a wide variety of neurobehavioral outcomes were assessed at various age ranges. The Bayley Scales of Infant Development (BSID) is widely used in longitudinal studies to assess cognitive and psychomotor development in young children [46,47,50,52,56]. Among the 6 studies that used BSID, 2 studies did not find any significant adverse effects of prenatal exposure to phthalates and cognitive, mental, and psychomotor development of children [46,47].…”

Section: Phthalates and Neurodevelopmentmentioning

confidence: 99%

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

Minatoya

Kishi

2021

IJERPH

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Purpose of Review: Bisphenol A and phthalate have been found in the environment, as well as in humans. In this narrative review pre- and postnatal bisphenol A and phthalate exposures, their relationship to neurodevelopment, and the behavioral outcomes of children are elucidated, focusing in particular on the recent case-control, cross-sectional, and longitudinal studies. This review also introduces some of the possible mechanisms behind the observed associations between exposures and outcomes. Recent Findings: Although bisphenol A and phthalate exposure have been reported to influence neurobehavioral development in children, there are various kinds of test batteries for child neurodevelopmental assessment at different ages whose findings have been inconsistent among studies. In addition, the timing and number of exposure assessments have varied. Summary: Overall, this review suggests that prenatal exposure to bisphenol A and phthalates may contribute to neurobehavioral outcomes in children. The evidence is still limited; however, Attention Deficit Hyperactivity Disorder (ADHD) symptoms, especially among boys, constantly suggested association with both prenatal and concurrent exposure to bisphenol A. Although there is limited evidence on the adverse effects of prenatal and postnatal bisphenol A and phthalate exposures provided, pregnant women and young children should be protected from exposure based on a precautionary approach.

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“…indices (Kim et al, 2011;Kim et al, 2018), motor scores (Torres-Olascoaga et al, 2020), attention (Hu et al, 2017), and internalizing and externalizing behavioral problems (Hu et al, 2017;Daniel et al, 2020), among others. In particular, numerous studies have linked DEHP metabolite exposure of children with an increased risk of attention deficit-hyperactivity disorder and severity of associated symptoms, with a negative impact of such exposure on regional cortical maturation (Kim et al, 2009;Chopra et al, 2014;Park et al, 2015;Hu et al, 2017; S.M.…”

Section: Discussionmentioning

confidence: 99%

Phasing out DEHP from plastic indwelling medical devices used for intensive care: Does it reduce the long-term attention deficit of critically ill children?

Vanhorebeek

Malarvannan

Güiza

et al. 2022

Environment International

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Prenatal and early childhood exposure to phthalates and childhood behavior at age 7 years

Cited by 42 publications

References 90 publications

Lifestyle Habits and Exposure to BPA and Phthalates in Women of Childbearing Age from Northern Italy: A Pilot Study

Lifestyle Habits and Exposure to BPA and Phthalates in Women of Childbearing Age from Northern Italy: A Pilot Study

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

Phasing out DEHP from plastic indwelling medical devices used for intensive care: Does it reduce the long-term attention deficit of critically ill children?

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