Prenatal and early childhood critical windows for the association of nephrotoxic metal and metalloid mixtures with kidney function

Sanders, Alison P.; Gennings, Chris; Tamayo‐Ortiz, Marcela; Mistry, Shachi; Pantic, Ivan; Martinez, Mauro; Estrada-Gutiérrez, Guadalupe; Espejel-Núñez, Aurora; Torres-Olascoaga, Libni A.; Wright, Robert O.; Téllez-Rojo, Martha M; Arora, Manish; Austin, Christine

doi:10.1016/j.envint.2022.107361

Cited by 27 publications

(11 citation statements)

References 55 publications

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“…This analysis found that the metal mixture in urine and blood are associated with increased eGFR and decreased cystatin C levels and that Cd and Pb are the main contributors of the mixture effects [53]. In addition, an analysis that included Cr and Li in the tooth-matrix from children from the same cohort found that exposure to a mixture of elements during the second and third trimester of gestation was the main window of vulnerability associated with children's decreased eGFR with Li and Cr as the main contributors of the mixture effect [54].…”

Section: Discussionmentioning

confidence: 99%

Chemical Element Mixtures and Kidney Function in Mining and Non-Mining Settings in Northern Colombia

Villamizar

Medina

Flórez-Vargas

et al. 2023

IJERPH

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The exposure to chemical mixtures is a problem of concern in developing countries and it is well known that the kidney is the major target organ for toxic elements. This cross-sectional study aimed to estimate the individual and composite mixture effect of a large number of chemical elements on kidney function in gold-mining and surrounding non-mining populations in northeast Colombia. We measured concentrations of 36 chemical elements in hair as indicators of chronic exposure from 199 adult participants. We estimated the effect of exposure to mixtures of chemical elements on estimated glomerular filtration rate (eGFR) using weighted quantile sum regression (WQS). The WQS index of the mixture was associated with reduced eGFR (Coefficient −2.42; 95%CI: −4.69, −0.16) being Be, Cd, Pb, As, and Mn, the principal contributors of the toxic mixture. Mining activities and Hg concentration were not associated with decreased kidney function. Our results suggest that complex mixtures of chemical elements, mainly heavy metals, act as nephrotoxic in these populations and therefore the analysis of chemical element mixtures is a better approach to identify environmental and occupational chemical risks for kidney damage.

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Section: Discussionmentioning

confidence: 99%

Chemical Element Mixtures and Kidney Function in Mining and Non-Mining Settings in Northern Colombia

Villamizar

Medina

Flórez-Vargas

et al. 2023

IJERPH

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“…As most families in the study belonged to the low to middle SES bracket, these six categories were consolidated into three broader classifications: lower, middle, and higher. 74 All of these covariates were adjusted for in the statistical models. This sub-study utilized convenience sampling due to proximity to study location, availability of mothers and their children at a given time, or their willingness to participate in the study.…”

Section: Methodsmentioning

confidence: 99%

Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood

Midya,

Nagdeo,

Lane

et al. 2024

Preprint

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Emerging research suggests that exposures to metals during pregnancy and gut microbiome (GM) disruptions are associated with depressive disorders in childhood. Akkermansia muciniphila, a GM bacteria, has been studied for its potential antidepressant effects. However, its role in the influence of prenatal metal exposures on depressive symptoms during childhood is unknown. Leveraging a well-characterized pediatric longitudinal birth cohort and its microbiome substudy (n=112) and using a state-of-the-art machine-learning model, we investigated whether the presence of A.muciniphila in GM of 9-11-year-olds modifies the associations between exposure to a specific group of metals (or metal-clique) during pregnancy and concurrent childhood depressive symptoms. Among children with no A.muciniphila, a metal-clique of Zinc-Chromium-Cobalt was strongly associated with increased depression score (P<0.0001), whereas, for children with A.muciniphila, this same metal-clique was weakly associated with decreased depression score(P<0.4). Our analysis provides the first exploratory evidence hypothesizing A.muciniphila as a probiotic intervention attenuating the effect of prenatal metal-exposures-associated depressive disorders in late childhood.

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“…Maternal SES during pregnancy was assessed based on the 1994 Mexican Association of Intelligence Agencies Market and Opinion (AMAI) rule 13*6, where families were categorized into six levels of SES based on 13 questions about household characteristics. Most families in PROGRESS were low to middle SES; therefore, the six levels were condensed into three: lower, middle, and higher …”

Section: Methodsmentioning

confidence: 99%

“…Most families in PROGRESS were low to middle SES; therefore, the six levels were condensed into three: lower, middle, and higher. 35 …”

Section: Methodsmentioning

confidence: 99%

Prenatal Lead Exposure Is Associated with Reduced Abundance of Beneficial Gut Microbial Cliques in Late Childhood: An Investigation Using Microbial Co-Occurrence Analysis (MiCA)

Midya,

Lane,

Gennings

et al. 2023

Environ. Sci. Technol.

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Many analytical methods used in gut microbiome research focus on either single bacterial taxa or the whole microbiome, ignoring multibacteria relationships (microbial cliques). We present a novel analytical approach to identify microbial cliques within the gut microbiome of children at 9−11 years associated with prenatal lead (Pb) exposure. Data came from a subset of participants (n = 123) in the Programming Research in Obesity, Growth, Environment and Social Stressors cohort. Pb concentrations were measured in maternal whole blood from the second and third trimesters of pregnancy. Stool samples collected at 9−11 years old underwent metagenomic sequencing to assess the gut microbiome. Using a novel analytical approach, Microbial Co-occurrence Analysis (MiCA), we paired a machine learning algorithm with randomization-based inference to first identify microbial cliques that were predictive of prenatal Pb exposure and then estimate the association between prenatal Pb exposure and microbial clique abundance. With second-trimester Pb exposure, we identified a two-taxa microbial clique that included Bif idobacterium adolescentis and Ruminococcus callidus and a three-taxa clique that also included Prevotella clara. Increasing second-trimester Pb exposure was associated with significantly increased odds of having the two-taxa microbial clique below the median relative abundance (odds ratio (OR) = 1.03, 95% confidence interval (CI) [1.01−1.05]). Using a novel combination of machine learning and causal inference, MiCA identified a significant association between second-trimester Pb exposure and the reduced abundance of a probiotic microbial clique within the gut microbiome in late childhood.

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Prenatal and early childhood critical windows for the association of nephrotoxic metal and metalloid mixtures with kidney function

Cited by 27 publications

References 55 publications

Chemical Element Mixtures and Kidney Function in Mining and Non-Mining Settings in Northern Colombia

Chemical Element Mixtures and Kidney Function in Mining and Non-Mining Settings in Northern Colombia

Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood

Prenatal Lead Exposure Is Associated with Reduced Abundance of Beneficial Gut Microbial Cliques in Late Childhood: An Investigation Using Microbial Co-Occurrence Analysis (MiCA)

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