Prenatal allergic sensitization to helminth antigens in offspring of parasite-infected mothers.

Weil, Gary J.; Hussain, Rabia; Kumaraswami, V.; Tripathy, S.P.; Phillips, Kimberley; Ottesen, Eric A.

doi:10.1172/jci110862

Cited by 119 publications

(71 citation statements)

References 17 publications

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“…Prior studies have shown that maternal helminth infections can induce fetal immune responses 18 and that prenatal sensitization to parasite antigens may have long term effects on immune responses to helminth antigens. 19 Lammie and others found that children of microfilaremic mothers in Haiti had higher infection prevalence rates than offspring of uninfected mothers.…”

Section: Discussionmentioning

confidence: 99%

A longitudinal study of Bancroftian filariasis in the Nile Delta of Egypt: baseline data and one-year follow-up.

Weil¹,

Ramzy²,

Setouhy³

et al. 1999

Am J Trop Med Hyg

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Abstract. We initiated a longitudinal study of Bancroftian filariasis to improve understanding of dynamics and risk factors for infection in villages near Cairo, Egypt. Baseline prevalence rates for microfilaremia and filarial antigenemia for 1,853 subjects more than 9 years of age were 7.7% and 11.2%, respectively. Microfilaria counts, antigen levels, and microfilaremia incidence over a 1-year period were all significantly lower in older people. These findings suggest that humans develop partial immunity to Wuchereria bancrofti over time. One-year incidence rates for microfilaremia and antigenemia were 1.8% and 3.1%, respectively. Filarial antigenemia, IgG4 antibody to recombinant antigen BmM14, and household infection were all significant risk factors for microfilaremia incidence. Microfilaria counts and parasite antigen levels were significantly reduced by diethylcarbamazine therapy, but many infected subjects refused treatment, and most treated people were still infected one year later. Incident infections approximately balanced infections lost to produce an apparent state of dynamic equilibrium.

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Section: Discussionmentioning

confidence: 99%

A longitudinal study of Bancroftian filariasis in the Nile Delta of Egypt: baseline data and one-year follow-up.

Weil¹,

Ramzy²,

Setouhy³

et al. 1999

Am J Trop Med Hyg

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“…This finding has prompted speculation about potential pathways for maternal influence on the fetal immune system, including transfer of mediator(s) from mother to child (e.g., allergens (5,6), Abs (7), or other immune mediators via the placenta (8,9)), which might prime or sensitize the developing individual for increased susceptibility to asthma (10,11). These postulates reflect experimental data demonstrating newborn immune responses to maternal vaccines or Ags in the maternal environment (5,12,13), but are somewhat in conflict with earlier observations that transfer of maternal Ag-specific IgG may protect against allergy by suppressing neonatal IgE responses (14). Progress in this area has been hampered by the lack of an experimental model and the complex epidemiology of asthma risk factors in people, including roles for genetic (15) and environmental (e.g., maternal smoking (16)) factors.…”

mentioning

confidence: 85%

“…1) to test the response of babies born to OVAallergic and exposed mothers to sensitization with a single i.p. injection of Cs, followed by challenge with Cs aerosols (days [12][13][14] and evaluation (day 15). Babies from OVA-asthmatic, but not normal, mother mice showed marked susceptibility to sensitization by the single i.p.…”

Section: Susceptibility To Respiratory Allergy To a Different Allergenmentioning

confidence: 99%

Allergen-Independent Maternal Transmission of Asthma Susceptibility

Hamada

Suzaki

Goldman

et al. 2003

The Journal of Immunology

123

175

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Maternal asthma is a risk factor for development of asthma in children, but mechanisms remain unclear. Offspring of asthmatic mother mice (sensitized and repeatedly exposed to OVA Ag) showed airway hyperresponsiveness and allergic pulmonary inflammation after an intentionally suboptimal OVA sensitization and exposure protocol that had little effect on normal offspring. Similar results were obtained when offspring of OVA-allergic mothers were exposed to an unrelated allergen, casein, indicating that the maternal effect is allergen independent and not transferred by OVA-specific Abs. Premating treatment with neutralizing anti-IL-4 Ab or reduction of maternal allergen exposure abrogated the maternal effect, showing a critical mechanistic role for IL-4 and suggesting an additional benefit of allergen avoidance.

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“…6,10,14,15 Because IgE and IgM isotypes normally do not cross the placental barrier, 3,6,16 the presence of these antibodies in umbilical cord blood is evidence of prenatal priming. It has previously been shown that in disease-endemic countries total 3,7,10,12 and filarial antigen-specific 3,7,10,12 fetal IgE production occurs. Only one investigation 6 demonstrated a direct correlation of enhanced cord blood helminth antigen-specific IgE levels with the corresponding maternal helminth (Onchocerca volvolus) infection, and other studies found no correlation.…”

Section: Introductionmentioning

confidence: 99%

“…However, there is increasing evidence of in utero sensitization as a result of maternal helminth infections. [2][3][4][5][6][7] The question of how infections and/or microbial products in the mother might affect the development of the fetal immune system is of particular interest because it may explain disease patterns later in life.…”

Section: Introductionmentioning

confidence: 99%

Association of In Utero Sensitization to Schistosoma haematobium with Enhanced Cord Blood IgE and Increased Frequencies of CD5– B Cells in African Newborns

Seydel

Petelski²,

Dam³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. This study investigated in utero priming as a consequence of maternal parasitic infections. Cord blood plasma samples of 63 African newborns were assessed by enzyme-linked immunosorbent assay for their content of total and schistosome-specific or filaria-specific IgE and IgG4. The frequencies of lymphocyte phenotypes in cord blood were also determined by using flow cytometry, and were compared with those of European newborns. We found significantly increased schistosome soluble egg antigen (SEA)-specific IgE in cord plasma of those born to mothers with schistosome infections and correlations between fetal and maternal SEA-specific and filaria antigen-specific IgE. These data are evidence for in utero priming of the fetal immune system to maternal helminth infections. Furthermore, we show significantly enhanced percentages of CD5-B cells in African newborns cord blood compared with Europeans, which is consistent with earlier maturation of the African fetal immune system.

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Prenatal allergic sensitization to helminth antigens in offspring of parasite-infected mothers.

Cited by 119 publications

References 17 publications

A longitudinal study of Bancroftian filariasis in the Nile Delta of Egypt: baseline data and one-year follow-up.

A longitudinal study of Bancroftian filariasis in the Nile Delta of Egypt: baseline data and one-year follow-up.

Allergen-Independent Maternal Transmission of Asthma Susceptibility

Association of In Utero Sensitization to Schistosoma haematobium with Enhanced Cord Blood IgE and Increased Frequencies of CD5– B Cells in African Newborns

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