“…Curiously, protein levels of total (pan‐AKT) and activated (pAKT Thr308 ) were higher in adipose tissue from PAE than control males, suggesting that PAE alters insulin signalling in fat (Nguyen et al . ), although these changes would be expected to enhance rather than impair insulin action in this tissue. Whether the insulin resistance observed in young adult males after PAE progresses to glucose intolerance or diabetes with ageing or other challenges such as obesity, or whether metabolic phenotypes emerge in females, remains to be assessed.…”