Prenatal alcohol consumption and open-field behaviour in rats: Effects of age at time of testing

Bond, Nigel W.; Giusto, Eros L. Di

doi:10.1007/bf00426717

Cited by 85 publications

(21 citation statements)

References 4 publications

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“…Furthermore, the increase in activity had disappeared by 28 days of age. The transient nature of the increase is also in agreement with previous work (Abel, 1982;Bond & DiGiusto, 1977).…”

Section: Discussionsupporting

confidence: 92%

Prenatal alcohol exposure and offspring hyperactivity: The effects of home-cage shavings and test chamber temperature

Bond

1985

Psychobiology

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Rats were fed a liquid diet containing alcohol from Days 6-19 of gestation. Controls were pairfed the same diet with sucrose substituted for ethanol, or were allowed ad-lib chow and water. The activity of the offspring was observed in isolation at 10, 16,22, or 28 days of age. Offspring exposed to alcohol prenatally were hyperactive relative to controls at 16 and 22 days, but not at 10 or 28 days. The presence of home-cage shavings in the test chamber affected the activity of the three groups similarly. In a second study, isolation-induced activity was observed at a test room temperature of 23 0 or 33 0 C. Offspring exposed to alcohol were hyperactive in comparison with pair-fed controls, at both 16 and 22 days, when tested at 23 0 C. However, the difference in activity was attenuated at 16 days and abolished at 22 days if pups were tested at 33 0 C. These findings indicate that the hyperactivity displayed by alcohol-treated offspring may be due in part to their experiencing greater thermal stress when removed from their dam and littermates.

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“…Furthermore, the increase in activity had disappeared by 28 days of age. The transient nature of the increase is also in agreement with previous work (Abel, 1982;Bond & DiGiusto, 1977).…”

Section: Discussionsupporting

confidence: 92%

Prenatal alcohol exposure and offspring hyperactivity: The effects of home-cage shavings and test chamber temperature

Bond

1985

Psychobiology

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“…These results may be because of locomotor hyperactivity often reported in children and in preweaning and juvenile rats after perinatal ethanol exposure (Bond and Di Giusto, 1977; Osborne et al ., 1980; Abel, 1982; Leonard, 1988; Abel and Reddy, 1997; Tran et al ., 2000; Mattson et al ., 2001). Given these observed swim speed differences, care was taken to use water maze performance measures that were minimally confounded by alterations in motor function.…”

Section: Discussionmentioning

confidence: 99%

Altered spatial learning and delay discounting in a rat model of human third trimester binge ethanol exposure

Bañuelos¹,

Gilbert

Montgomery³

et al. 2012

Behavioural Pharmacology

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Ethanol exposure during perinatal development can cause cognitive abnormalities including difficulties in learning, attention, and memory, as well as heightened impulsivity. The purpose of this study was to assess performance in spatial learning and impulsive choice tasks in rats subjected to an intragastric intubation model of binge ethanol exposure during human third trimester-equivalent brain development. Male and female Sprague–Dawley rat pups were intubated with ethanol (5.25 g/kg/day) on postnatal days 4–9. At adolescence (between postnatal days 35–38), these rats and sham intubated within-litter controls were trained in both spatial and cued versions of the Morris water maze. A subset of the male rats was subsequently tested on a delay-discounting task to assess impulsive choice. Ethanol-exposed rats were spatially impaired relative to controls, but performed comparably to controls on the cued version of the water maze. Ethanol-exposed rats also showed greater preference for large delayed rewards on the delay discounting task, but no evidence for altered reward sensitivity or perseverative behavior. These data demonstrate that early postnatal intermittent binge-like ethanol exposure has prolonged, detrimental, but selective effects on cognition, suggesting that even relatively brief ethanol exposure late in human pregnancy can be deleterious for cognitive function.

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“…Francis et al . (1999) used circular open field sized 1.6 m in diameter, Alstott and Timberlake (2009) used an arena with 1.67 m in diameter and Bond and Di Giusto (1977) with 0.92 m in diameter. Regarding colour, usually all walls and floor of the open field are black but some authors used floor and walls painted white (Berton et al ., 1997).…”

Section: Open Field Test: Equipment and Procedures Of Testingmentioning

confidence: 99%

Determination of motor activity and anxiety-related behaviour in rodents: methodological aspects and role of nitric oxide

Sestakova¹,

Púzserová²,

Kluknavsky³

et al. 2013

Interdisciplinary Toxicology

251

139

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In various areas of the bio-medical, pharmacological and psychological research a multitude of behavioural tests have been used to investigate the effects of environmental, genetic and epi-genetic factors as well as pharmacological substances or diseased states on behaviour and thus on the physiological and psycho-social status of experimental subjects. This article is reviewing the most frequently used behavioural tests in animal research (open field, elevated plus maze, zero maze, and black and white box). It provides a summary of common characteristics as well as differences in the methods used in various studies to determine motor activity, anxiety and emotionality. Additionally to methodological aspects, strain, sex and stress-related differences as well as the involvement of nitric oxide in modulation of motor activity and anxiety of rodents were briefly reviewed.

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Prenatal alcohol consumption and open-field behaviour in rats: Effects of age at time of testing

Cited by 85 publications

References 4 publications

Prenatal alcohol exposure and offspring hyperactivity: The effects of home-cage shavings and test chamber temperature

Prenatal alcohol exposure and offspring hyperactivity: The effects of home-cage shavings and test chamber temperature

Altered spatial learning and delay discounting in a rat model of human third trimester binge ethanol exposure

Determination of motor activity and anxiety-related behaviour in rodents: methodological aspects and role of nitric oxide

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