Prenatal alcohol consumption and fetal growth restriction: Potentiation effect by concomitant smoking

Aliyu, Muktar H.; Wilson, Roneé E.; Zoorob, Roger; Brown, Kristal; Alio, Amina P.; Clayton, Heather B.; Salihu, Hamisu M.

doi:10.1093/ntr/ntn014

Cited by 61 publications

(60 citation statements)

References 46 publications

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“…30,31 The present results showed significant interaction between alcohol consumption and smoking with regard to the risk of LBW, SGA and preterm birth. Smoking and stress may create a biological environment in which alcohol has more adverse effects due to interactive mechanisms.…”

Section: Discussionsupporting

confidence: 51%

“…Several biochemical interactions caused by alcohol and tobacco, with vitamins, folates and other antioxidants, may affect fetal growth during pregnancy. 3,31 In addition, the vasoconstriction of the placenta-umbilical cord unit due to alcohol and tobacco consumption reduces the rate of alcohol elimination from the fetal compartment. 25 Several limitations of the present study need to be mentioned.…”

Section: Discussionmentioning

confidence: 99%

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Alcohol consumption during pregnancy and perinatal results: a cohort study

et al. 2016

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CONTEXT AND OBJECTIVE: Alcohol consumption during pregnancy is a significant social problem that may be associated with adverse perinatal outcomes. The aim of this study was to describe alcohol consumption during pregnancy and to study its association with low birth weight, newborns small for gestational age and preterm birth. DESIGN AND SETTING: Nested cohort study, in the city of Ribeirão Preto, São Paulo, Brazil. METHODS: 1,370 women and their newborns were evaluated. A standardized questionnaire on health and lifestyle habits was applied to the mothers. Anthropometry was performed on the newborns. Alcohol consumption was defined as low, moderate or high, as defined by the World Health Organization. Adjusted logistic regression analysis was used. RESULTS: 23% of the women consumed alcohol during pregnancy. Consumption mainly occurred in the first trimester (14.8%) and decreased as the pregnancy progressed. The median alcohol intake was 3.89 g (interquartile range, IQR = 8 g) per day. In the unadjusted analysis, alcohol consumption increased the risk of low birth weight almost twofold (odds ratio, OR 1.91; 95% confidence interval, CI: 1.25-2.92). The risk was lower in the adjusted analysis (OR 1.62; 95% CI: 1.03-2.54). Alcohol consumption did not show associations with small for gestational age or preterm birth. There was greater risk of low birth weight and newborns small for gestational age and preterm birth among mothers who were both smokers and drinkers. CONCLUSIONS: The alcohol consumption rate during pregnancy was 23% and was independently associated with low birth weight, but there was no risk of newborns small for gestational age or preterm birth.RESUMO CONTEXTO E OBJETIVO: O consumo de álcool durante a gravidez é um problema social significativo que pode estar associado a resultados perinatais adversos. O objetivo deste estudo foi descrever o consumo de álcool na gestação e avaliar sua associação com recém-nascido de baixo peso, pequeno para idade gestacional e pré-termo. TIPO DE ESTUDO E LOCAL: Estudo de coorte aninhado, na cidade de Ribeirão Preto, São Paulo, Brasil. MÉTODOS: Foram avaliadas 1.370 mulheres e seus recém-nascidos. Foi aplicado às mães um questionário padronizado sobre saúde e hábitos de vida. Antropometria foi realizada nos recém-nascidos. Consumo de álcool foi definido como baixo, moderado e elevado segundo a Organização Mundial de Saúde. Foi utilizada análise de regressão logística ajustada. RESULTADOS: 23% das gestantes consumiram álcool durante a gravidez. A maior parte do consumo ocorreu no primeiro trimestre (14,8%) e diminuiu conforme progredia a gravidez. A mediana de ingestão de álcool foi de 3,89 g (interval interquartil, IIQ = 8 g) por dia. Na análise não ajustada, o consumo de álcool aumentou em quase duas vezes (odds ratio, OR 1,91, intervalo de confiança, IC 95%; 1,25-2,92) o risco de baixo peso, que se reduziu após ajuste (OR 1,62; IC 95%; 1,03-2,54). Não houve associação entre consumo de álcool e pequeno para idade gestacional ou pré-termo. Observou-se maior r...

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Alcohol consumption during pregnancy and perinatal results: a cohort study

et al. 2016

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“…A number of studies in humans have collectively suggested that prenatal exposure to alcohol and tobacco products may have a synergistic effect on newborn size (Aliyu et al, 2009;Olsen et al, 1991;Brooke et al, 1989;Haste et al, 1991). These studies are supported by experimental studies using animal models which have identified synergistic effects on fetal size, fetal dysmorphology, and embryonic lethality (Leichter, 1989;Peterson et al, 1981;Fazel, 1996).…”

Section: Establishment Of Mouse Modelsmentioning

confidence: 97%

“…A study that utilised data from 655 758 singleton pregnancies in Missouri, USA found an increased risk of infants being identified as small for gestational age when exposed to both alcohol and tobacco products during gestation when compared to either exposure alone (Aliyu et al, 2009). …”

Section: Evidence In Humansmentioning

confidence: 99%

“…Furthermore, a number of studies have identified a potentiating effect of alcohol on the effect of tobacco products on newborn size in humans (Aliyu et al, 2009;Brooke et al, 1989;Haste et al, 1991;Olsen et al, 1991). Consequently, the following chapter of this thesis will focus on examining whether prenatal ethanol and/or nicotine affects offspring growth.…”

Section: Establishment Of Mouse Modelsmentioning

confidence: 99%

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A study of the consequences of early gestational ethanol and/or nicotine exposure in the mouse

Yamada¹

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The in utero environment is a critical determinant of the immediate and future health of the developing fetus. In Australia, two of the most commonly used drugs during pregnancy are alcohol and nicotine. Prolonged periods of gestational exposure to alcohol and nicotine, separately, have been associated with a range of adverse outcomes in the offspring, in both humans and experimental animal models. The consequences of ethanol and nicotine exposure restricted to early gestation on resultant offspring are poorly characterised, and few animal models exist to build greater understanding. Moreover, the immediate molecular changes associated with exposures to ethanol and/or nicotine restricted to early gestation has yet to be described.This thesis utilised mouse models of early gestational ethanol and/or nicotine exposure to explore the impact of each of these exposures on offspring growth, as well as their associated transcriptional and epigenetic changes. In each model, pregnant C57BL/6 dams were provided with ad libitum access to solutions of 10% ethanol and/or 100 µg/ml nicotine from fertilisation (0.5 dpc) to midgestation (8.5 dpc). The exposure window utilised in each of the models is developmentally equivalent to the first three to four weeks of a human pregnancy.Previously, our laboratory identified reduced growth, microcephaly, and gene expression changes in the liver and hippocampus of the postnatal offspring of the model of prenatal ethanol exposure utilised in this thesis. In contrast, at mid-gestation (9.5 dpc), there was no evidence of developmental delay (somite number), reduced growth (crown-rump length), or microcephaly.Further, a genome-wide gene expression microarray (targeting 30 855 genes) and a screen of the expression of 641 microRNAs, identified only one gene (Bcl11b) as differentially expressed in male 9.5 dpc whole embryos following the ethanol exposure. These data suggest that there is a delay between the ethanol exposure and the onset of adverse phenotypes -arguing that the embryo is somehow able to form a memory of the ethanol exposure. The absence of widespread transcriptional changes suggests that changes in embryonic mRNA and microRNA expression are unlikely to be major contributors to the memory of the exposure.A early gestational model of nicotine exposure was newly established in this thesis. This nicotine exposure resulted in an average serum cotinine (metabolite of nicotine) concentration similar to that reported in humans who smoke 10 to 15 cigarettes per day. This exposure was sufficient to induce a reduction in body size both at mid-gestation and postnatally, but not at late gestation. Furthermore, the increased expression of Zscan10 in the whole male 9.5 dpc embryo was identified and validated across multiple cohorts. Zscan10 encodes for a transcription factor expressed throughout development, with a proposed role in the regulation of progenitor cells. The increased expression of Zscan10 in the nicotine-exposed embryos was associated with a reduction in DNA methylation ...

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Association of Prenatal Exposure to Maternal Drinking and Smoking With the Risk of Stillbirth

et al. 2021

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Key Points Question Is prenatal exposure to maternal drinking and smoking associated with the risk of stillbirth? Findings In this cohort study of 8506 pregnant women (with 11 892 pregnancies) in Cape Town, South Africa, and the Northern Plains in the US, dual exposure to drinking and smoking after the first trimester of pregnancy had 2.78 times the risk of late stillbirth compared with those with no exposure or who had quit before the end of the first trimester of pregnancy. Meaning These findings suggest that dual exposure to drinking and smoking after the first trimester of pregnancy is associated with nearly 3 times the risk of late stillbirth.

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Prenatal alcohol consumption and fetal growth restriction: Potentiation effect by concomitant smoking

Cited by 61 publications

References 46 publications

Alcohol consumption during pregnancy and perinatal results: a cohort study

Alcohol consumption during pregnancy and perinatal results: a cohort study

A study of the consequences of early gestational ethanol and/or nicotine exposure in the mouse

Association of Prenatal Exposure to Maternal Drinking and Smoking With the Risk of Stillbirth

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