Prenatal administration of progestogens for preventing preterm birth in women with a multiple pregnancy

Dodd, Jodie M; Grivell, Rosalie M; O’Brien, Cecelia M.; Dowswell, Therese; Deussen, Andrea R

doi:10.1002/14651858.cd012024

Cited by 5 publications

(2 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During puberty, sexual steroids such as estrogen and progesterone will increase; these hormones impress hematopoiesis and play a role in the reduction of hemoglobin in the pregnancy period. The levels of the steroid hormones (estrogen and progesterone) are high, while the mother's hemoglobin concentration is reduced during the pregnancy period 37 .…”

Section: Introductionmentioning

confidence: 99%

The effect of delivery type on neonatal blood indices in an Iranian population

et al. 2018

View full text Add to dashboard Cite

Background: Generally, there are two methods for childbirth: normal vaginal and cesarean section (C-section). Each method has advantages and complications. In this study, we investigated the effects of type of delivery on hematological parameters in healthy full-term neonates in an Iranian population, from 2016-2017. Materials: Three hundred pregnant women, along with their healthy and term babies, were studied. According to the route of delivery, the neonates were divided into two groups: vaginal (n=150) and C-section (n=150). Complete blood count (CBC) and peripheral blood smear (PBS) were performed on the neonates from umbilical cord blood immediately after birth. Data were analyzed by using SPSS v. 22 and statistical analyses were done by student's t-test and correlation tests, with P-value < 0.05 set as the lowest limit of significance. Results: We observed a significant increase in hematologic parameters, such as red blood cell (RBC) count, hemoglobin, hematocrit, red cell distribution width (RDW), platelets, total leukocyte count and neutrophil count, in full-term neonates who delivered vaginally compared to those delivered by cesarean section (p<0.001). However, there was no significant difference between the delivery types in terms of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean platelet volume (MPV), platelet distribution width (PDW), eosinophil count, lymphocyte count, or monocyte count. Conclusion: According to our study, the mode of delivery influences the hematological parameters in full-term neonates; thrombocytopenia and anemia in neonates were associated with cesarean section delivery. Thus, we recommend that pregnant women do not deliver by C-section unless in emergency situations.

show abstract

Section: Introductionmentioning

confidence: 99%

The effect of delivery type on neonatal blood indices in an Iranian population

et al. 2018

View full text Add to dashboard Cite

show abstract

“…If the current evidence is taken into account, progesterone has not been shown to decrease preterm birth in twin pregnancies [63]. This conclusion is supported by a Cochrane review [64] that analyzed the effectiveness of progesterone (both vaginal Risks Versus Benefits of Using Aspirin, Magnesium Sulfate, Corticosteroids, and Progesterone… DOI: http://dx.doi.org/10.5772/intechopen.1004594 and IM) as prophylaxis in twin pregnancies (16 randomized studies with placebo, 4548 pregnant women). A higher percentage of delivery <34 weeks was observed in the group treated with c17-OHP than in the placebo group (RR 1.54; 95% CI: 1.06-2.26).…”

Section: Impact Of Progesterone In Twin Pregnanciesmentioning

confidence: 82%

Risks Versus Benefits of Using Aspirin, Magnesium Sulfate, Corticosteroids, and Progesterone during Pregnancy

Valdés Rubio,

Flores Belkerbach

2024

Best and Safe Practices in Different Contexts of Neonatal Care

View full text Add to dashboard Cite

This chapter will discuss various prophylactic and therapeutic strategies based on a review of the literature that is based on the best evidence. In this way, we will know the effect of aspirin as a prophylactic measure in the prevention of severe preeclampsia. Then, we treat the impact of magnesium sulfate to significantly reduce intracranial hemorrhage and cerebral palsy. Following this, we examine the impact of corticosteroids in premature pregnancies in different clinical scenarios, demonstrating their efficacy in improving neonatal prognosis. Finally, we will see the effect of progesterone in reducing premature labor. The use of these strategies has allowed for an improvement in perinatal morbidity and mortality due to the intrinsic beneficial effects of these drugs, as well as a decrease in prematurity (aspirin and progesterone).

show abstract