Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth

Jm, Dodd; Flenady, Vicki; Cincotta, Robert; Crowther, CA

doi:10.1002/14651858.cd004947.pub2

Cited by 134 publications

(100 citation statements)

References 114 publications

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“…prior PTB), short TVU CL (and degree of) or not, asymptomatic vs PTL and PPROM, etc, are all factors which should be considered, as progestogens have different effects in populations with any one (or combination of) risk factor. Several meta-analyses have been published (4,(66)(67)(68), but they either do not evaluate these studies according to the different populations just mentioned, or soon become out-of-date because of publications of new RCTs.…”

Section: Discussionmentioning

confidence: 99%

Progesterone and preterm birth prevention: translating clinical trials data into clinical practice

Berghella¹

2012

American Journal of Obstetrics and Gynecology

292

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Section: Discussionmentioning

confidence: 99%

Progesterone and preterm birth prevention: translating clinical trials data into clinical practice

Berghella¹

2012

American Journal of Obstetrics and Gynecology

292

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“…The likelihood of preterm birth can be lowered by more than 30%, both in women with a prior history of preterm birth (OR 0.65, 95% CI 0.54-0.79) (14) and in those whose cervix is currently shortened (OR 0.69, 95% CI 0.55-0.88) (15).…”

Section: Progesterone Supplementationmentioning

confidence: 99%

The Prevention, Diagnosis and Treatment of Premature Labor

Schleußner¹

2013

Deutsches Ärzteblatt International

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“…Progesterone is critical for maintaining pregnancy and decline of progesterone action is implicated in the onset of parturition. Prenatal administration of progesterone has significantly decreased the PTB in women considered to be at increased risk (24,25). We can speculate that women with polymorphisms in NR5A2 gene and resulting functional variations of LRH1 are at risk of PTB due to low progesterone levels and lack of progesterone-dependent actions on the uterus.…”

Section: Resultsmentioning

confidence: 91%

Polymorphisms in NR5A2, gene encoding liver receptor homolog-1 are associated with preterm birth

et al. 2016

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Background. Preterm birth (PTB) is a major cause of neonatal mortality and morbidity. There is strong evidence of genetic susceptibility. Objective of the study was to identify genetic variants contributing to PTB. Methods. Genotyping was performed for 24 SNPs in 4 candidate genes (NR5A2, FSHR, FOXP3, SERPINH1). Genotyping was completed on 728 maternal triads (mother & maternal grandparents of a preterm infant). Data were analyzed with Family Based Association Test. Results. For all maternal triads rs2737667 of NR5A2 showed significant association at P= 0.02. When stratifying by gestational age three SNPs in NR5A2 had p values <0.05 in the <32 weeks gestational age group (rs12131233, p=0.007; rs2737667, p=0.04; rs2816949, p=0.02). When PPROM cases were excluded rs2737667 of NR5A2 showed the strongest association with a p value <0.0002. This association remained significant after correction for multiple testing. Conclusions. This study suggests a potential association between intronic SNPs in the NR5A2 gene and PTB. NR5A2 gene encodes for the Liver receptor homolog 1(LRH1) protein, which plays a critical role in regulation of cholesterol metabolism, steroidogenesis and progesterone synthesis. These findings suggest NR5A2 may be important in the pathophysiology of PTB and exploring of non-coding regulators of NR5A2 is warranted.

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Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth

Cited by 134 publications

References 114 publications

Progesterone and preterm birth prevention: translating clinical trials data into clinical practice

Progesterone and preterm birth prevention: translating clinical trials data into clinical practice

The Prevention, Diagnosis and Treatment of Premature Labor

Polymorphisms in NR5A2, gene encoding liver receptor homolog-1 are associated with preterm birth

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