Premorbid Intellectual Functioning in Bipolar Disorder and Schizophrenia: Results From a Cohort Study of Male Conscripts

Tiihonen, Jari; Haukka, Jari; Henriksson, Markus; Cannon, Mary; Kieseppä, Tuula; Laaksonen, Ilmo; Sinivuo, Juhani; Lönnqvist, Jouko

doi:10.1176/appi.ajp.162.10.1904

Cited by 166 publications

(163 citation statements)

References 31 publications

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“…The strengths of the sample include the fact that it is nationwide, a follow-up rate of 91%, and the use of a nationwide well-documented register [28, 37,38]. However, several limitations should be considered when interpreting the results of this study.…”

Section: Discussionmentioning

confidence: 99%

“…Information about psychiatric hospital treatment between 1.1.1994 and 31.12.2005 was based on the National Hospital Register in Finland, which is extensively documented in psychiatric research [19,28,37,38]. The register covers the diagnosis and the day of admission in all general, mental and private hospital inpatient care units in Finland.…”

Section: The Outcomementioning

confidence: 99%

“…We used a nationwide birth cohort, consisting of one tenth of all eight-year-olds born in Finland in 1981, and linked it 16 years later to the Finnish National Hospital Discharge Register [13,28,37,38]. Because of the sex differences in disorder prevalence through childhood and adolescence [32,34] and the differing developmental pathways in the sexes [15,32], we performed all analyses separately for males and females.…”

Section: Introductionmentioning

confidence: 99%

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Childhood predictors of later psychiatric hospital treatment: findings from the Finnish 1981 birth cohort study

Gyllenberg

Sourander

Niemelä

et al. 2010

Eur Child Adolesc Psychiatry

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Psychiatric hospital treatment (PHT) is expensive and indicates a severe disorder. Investigation of the early identification of this small patient group has though been hindered by small samples or unsatisfactory assessment in childhood. The present study aims to study the predictive association between psychopathology at age 8 using multi-informant assessment and later PHT. A nationwide birth cohort of Finnish children (n = 5,346) was assessed at age 8 to obtain information about psychopathology using the Rutter parent and teacher reports and self-reports of depressive symptoms. The main outcome was admission to any hospital with a primary diagnosis of any psychiatric disorder according to the Finnish National Hospital Discharge Register between age 13 and 24. Between age 13 and 24, 6.2% of the males and 4.1% of the females had been admitted for PHT. Among males, PHT was independently predicted by non-intact family and adult reports of conduct and of emotional symptoms, while among females by self-reported depressive symptoms. However, the combination of conduct and emotional problems was the strongest predictor for PHT in both sexes. Admission due to psychosis among males was associated with childhood conduct, attention, and emotional problems, but with emotional problems among females. Psychopathology at age 8 can be seen as a long-lasting increased risk of severe psychiatric disorders requiring hospital treatment in adolescence or early adulthood. Attention should be paid to self-reports among females and of comorbid conduct and emotional problems in both sexes in the early identification of this patient group

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Section: Discussionmentioning

confidence: 99%

Section: The Outcomementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Childhood predictors of later psychiatric hospital treatment: findings from the Finnish 1981 birth cohort study

Gyllenberg

Sourander

Niemelä

et al. 2010

Eur Child Adolesc Psychiatry

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“…Preliminary data suggest that cognitive deficits are detectable in first-degree relatives (20,46,67), precede or are present at illness onset (24,68), and progress throughout the course of the illness (69), raising the likelihood of both genetic ⁄ neurodevelopmental and neurodegenerative components. Clearly, longitudinal studies in patients and high risk groups are needed to more adequately investigate these important etiological questions.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Neuropsychological functioning in euthymic bipolar disorder: a meta‐analysis

Torres

Boudreau

Yatham

2007

Acta Psychiatr Scand

526

364

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IntroductionIt is well established that patients with bipolar disorder in acute manic-depressive states show considerable cognitive impairment (1-3). In recent years, however, there has been a strong shift towards studying neurocognitive functions in euthymic patients with bipolar disorder. These Torres IJ, Boudreau VG, Yatham LN. Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis.Objective: Although cognitive deficits are prominent in symptomatic patients with bipolar disorder, the extent and pattern of cognitive impairment in euthymic patients remain uncertain. Method: Neuropsychological studies comparing euthymic bipolar patients and healthy controls were evaluated. Across studies, effect sizes reflecting patient-control differences in task performance were computed for the 15 most frequently studied cognitive measures in the literature. Results: Across the broad cognitive domains of attention ⁄ processing speed, episodic memory, and executive functioning, medium-to-large performance effect size differences were consistently observed between patients and controls, favoring the latter. Deficits were not observed on measures of vocabulary and premorbid IQ. Conclusion: Meta-analytic findings provide evidence of a trait-related neuropsychological deficit in bipolar disorder involving attention ⁄ processing speed, memory, and executive function. Findings are discussed with regard to potential moderators, etiologic considerations, limitations, and future directions in neuropsychological research on bipolar disorder.

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“…59,66 For instance, three ''conscript'' studies included young adults recruited from the armed forces and followed these individuals prospectively over long periods, but provided inconsistent or inconclusive findings. [77][78][79] Zammit et al 79 suggested that individuals who developed BD had cognitive performance comparable to that of healthy controls, while Tiihonen et al 78 showed that individuals who developed BD had superior performance in arithmetic but poorer visuospatial reasoning than healthy controls.…”

Section: Neurocognitionmentioning

confidence: 99%

Challenges and developments in research of the early stages of bipolar disorder

Brietzke

Rosa

Pedrini

et al. 2016

Rev. Bras. Psiquiatr.

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Recently, attention in the field of bipolar disorder (BD) has focused on prevention, including early detection and intervention, as these strategies have the potential to delay, lessen the severity, or even prevent full-blown episodes of BD. Although knowledge of the neurobiology of BD has advanced substantially in the last two decades, most research was conducted with chronic patients. The objective of this paper is to comprehensively review the literature regarding the early stages of BD, to explore recent discoveries on the neurobiology of these stages, and to discuss implications for research and clinical care. The following databases were searched: PubMed, PsycINFO, Cochrane Library, and SciELO. Articles published in English from inception to December 2015 were retrieved. Several research approaches were used, including examination of offspring studies, retrospective studies, prospective studies of clinical high-risk populations, and exploration of the progression after the first manic episode. Investigations with neuroimaging, cognition assessments, and biomarkers provide promising (although not definitive) evidence of alterations in the neural substrate during the at-risk stage. Research on BD should be expanded to encompass at-risk states and aligned with recent methodological progress in neuroscience.

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Premorbid Intellectual Functioning in Bipolar Disorder and Schizophrenia: Results From a Cohort Study of Male Conscripts

Cited by 166 publications

References 31 publications

Childhood predictors of later psychiatric hospital treatment: findings from the Finnish 1981 birth cohort study

Childhood predictors of later psychiatric hospital treatment: findings from the Finnish 1981 birth cohort study

Neuropsychological functioning in euthymic bipolar disorder: a meta‐analysis

Challenges and developments in research of the early stages of bipolar disorder

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