Premorbid functioning in schizophrenia spectrum disorders with comorbid substance use: A systematic review

Premorbid functioning in adolescence associates with comorbid disorders in individuals at ultra‐high risk for psychosis: A brief report

“…Rejecting our third hypothesis, no significant associations existed between lower PA academic, good PA social, and substance use disorders thus contrasting schizophrenia studies finding significant relations between these measures (Prat et al, 2021). This discrepancy may be explained by methodological variabilities.…”

“…An explanation of our limited significant findings could be that the SCID Axis I and II disorders cover different sub-disorders potentially pulling the results in opposite directions as demonstrated in schizophrenia studies (Birchwood et Parnas, 1990;Prat et al, 2021;Romm et al, 2012;Salagre et al, 2020). Hence, future studies should therefore elaborate on associations between PA and distinct comorbid disorders in larger samples with adequate statistical power.…”

“…Existing literature reports no associations between psychiatric diagnoses and PA academic except for a review on substance use disorders linking these to worse PA academic but better PA social (Prat et al, 2021).…”

“…Regarding established psychotic disorders, studies link poor PA social to comorbid disorders like social anxiety, substance use, affective, and premorbid personality disorders (Castle et al, 1993; McGlashan, 1986; Solano & de Chávez, 2005). Existing literature reports no associations between psychiatric diagnoses and PA academic except for a review on substance use disorders linking these to worse PA academic but better PA social (Prat et al, 2021).…”

Does nicotine exposure during adolescence modify the course of schizophrenia-like symptoms? Behavioral analysis in a phencyclidine-induced mice model

“…However, scant studies in prodrome patients and in animal models of SCHZ investigated this comorbidity during adolescence, which has the potential to identify mechanisms of nicotine interference in the development of SCHZ. This investigation is particularly relevant, since recognizing the period of adolescence as critical for nicotine addiction and SCHZ comorbidity creates the opportunity of early intervention, which could mitigate deleterious outcomes of these diseases [ 109 ]. Here, by using animal models of adolescent exposure, we demonstrated that nicotine history during adolescence is associated with remediation of positive and negative symptoms.…”