Premorbid factors and outcome associated with respiratory virus infections in a pediatric intensive care unit

Abstract

In PICU, respiratory viral infections were associated with significant morbidity and life-threatening conditions.

Childhood Pneumococcal Diseases and Serotypes: Can Vaccines Protect?

“…Adenovirus has been found to be associated with poor prognosis, with two out of 4 PICU deaths in our previous series [15,16]. The case with unexpected H9 avian influenza illustrates that influenza A virus association may lead to increased morbidity with the pneumococcal infection.…”

The frequency of influenza and bacterial coinfection: a systematic review and meta‐analysis

“…A total of 27 articles encompassing 3215 patients met all the inclusion criteria and were included in the final analysis 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54. Of those 27, only eight studies, with 334 patients, provided the numbers or percentages of each bacterial coinfecting pathogen 28, 32, 33, 34, 38, 43, 46, 47. Thus, these eight studies formed the basis for identifying the most common coinfecting bacterial pathogens (Figure 1).…”

“…Most studies enrolled only adults, although the lower age cutoffs varied (e.g., some studies considered adults older than 14 while others used 21). Only seven studies (1214 patients) focused on young children or newborns,29, 31, 38, 46, 49, 51, 54 and two studies (504 patients) included both children and adults 42, 53. Severity of illness varied among studies, but all were focused on hospitalized patients, suggesting a greater than average severity.…”

“…Severity of illness varied among studies, but all were focused on hospitalized patients, suggesting a greater than average severity. Eleven of the studies (1007 patients) focused exclusively on patients initially enrolled in an intensive care unit (ICU),32, 34, 35, 38, 39, 41, 42, 44, 46, 47, 51 10 enrolled non‐ICU hospitalized patients (973 patients),30, 33, 36, 37, 40, 43, 45, 49, 53, 54 3 enrolled patients in the emergency department (ED; 135 patients),28, 48, 50 and 2 enrolled patients in a mix of inpatient and outpatient settings (1100 patients) 29, 52. The median sample size was 51 (IQR, 18·5–101), and the mean was 119 (SD: 203), which was driven by three large studies29, 44, 53 that contributed 1958 (61%) of the total number of patients included in this analysis.…”

Respiratory syncytial virus morbidity, premorbid factors, seasonality, and implications for prophylaxis

“…Respiratory syncytial virus (RSV) is a common respiratory virus causing bronchiolitis and bronchopneumonia in infancy [1][2][3][4]. It is an important cause of viral infection requiring pediatric intensive care unit (PICU) admissions.…”