Premorbid body mass index and mortality in patients with lung cancer: A systematic review and meta-analysis

Independent and joint associations of blood lipids and lipoproteins with lung cancer risk in Chinese males: A prospective cohort study

“…Alcohol consumption has also been suggested to be associated with an increased risk of lung cancer . Previous studies have confirmed substantial BMI gradients are associated with lung cancer incidence and mortality, and lower lung cancer risk and death were observed in individuals with higher BMI . Therefore, when these established risk factors play primary roles in the development of lung cancer, the effect of TC might be weakened.…”

“…46,47 Previous studies have confirmed substantial BMI gradients are associated with lung cancer incidence and mortality, and lower lung cancer risk and death were observed in individuals with higher BMI. 4,48 Therefore, when these established risk factors play primary roles in the development of lung cancer, the effect of TC might be weakened. Therefore, the results of the present study suggested that TC, TG, and LDL-C might be important and potentially modifiable exposures that may have key scientific and clinical importance for preventing lung cancer development, particularly in never smokers, never drinkers and overweight/obese males.…”

Pre-Disease and Pre-Surgery BMI, Weight Loss and Sarcopenia Impact Survival of Resected Lung Cancer Independently of Tumor Stage

“…In contrast to the widely accepted idea that higher Body Mass Index (BMI) decreases the survival of many malignant tumors (such as colonic, pancreatic and post-menopausal breast cancers) and increases their incidence [1], obesity (defined as BMI >30 kg/m 2 ) would be protective for survival and/or occurrence of few malignancies, including large B-cell lymphomas, renal, and non-small cell lung cancer (NSCLC) [2]. This "obesity paradox" has been suggested by epidemiological studies [3] and recent meta-analysis dealing particularly with NSCLC [4,5]. However, these studies were unable to determine if these differences in survival are really due to BMI or to possibly related confounding factors, such as the extent of disease which was most often not recorded.…”

Cancer development in COPD patients: retrospective analysis of the National Health Insurance Service-National Sample Cohort in Korea

“…Our nding that a reduced BMI was independently linked to the development of lung cancer contradicts the conventional notion that obesity is pathogenically linked to carcinogenesis [32,33]. Several studies highlighted an obesity paradox suggesting that obesity may be protective and associated with reduced lung cancer mortality after surgery or chemotherapy [32,34,35]. Although the mechanisms behind this paradoxical relationship are not fully understood, anti-tumor adipokines, anti-tumor energy reserve, metabolic tness, relative lack of sarcopenia, etc., have been suggested as potential biological mechanisms to explain this obesity paradox [34].…”

“…Although the mechanisms behind this paradoxical relationship are not fully understood, anti-tumor adipokines, anti-tumor energy reserve, metabolic tness, relative lack of sarcopenia, etc., have been suggested as potential biological mechanisms to explain this obesity paradox [34]. Most studies, however, have focused on the mortality of patients with lung cancer after surgery or chemotherapy [32,34,35]. Our study is different from previous studies on the prognosis after a lung cancer diagnosis because we investigated the development of cancers in a cancer-free cohort by a longitudinal design [32,34,35].…”