Premorbid asocial adjustment and prognosis in schizophrenia

Gittelman-Klein, Rachel; Klein, Donald F.

doi:10.1016/0022-3956(69)90010-7

Cited by 238 publications

(78 citation statements)

References 30 publications

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“…An interview was conducted to gather information and observations necessary for completion of ratings on the Scale for the Assessment of Negative Symptoms (Andreasen, 1983), the Scale for the Assessment of Positive Symptoms (Andreasen, 1984), and a Premorbid Adjustment Scale (PAS; Gittelman-Klein and Klein, 1969). Most recent MMSE and Brief Psychiatric Rating Scale (BPRS) ratings were obtained from clinical charts.…”

Section: Methodsmentioning

confidence: 99%

Social Cognition and Symptom Dimensions

Shean

Murphy²,

Meyer³

2005

The Journal of Nervous and Mental Disease

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This study used the Picture Arrangement subtest of the Wechsler Adult Intelligence Scale to assess social cognitive functioning of psychotic patients diagnosed with bipolar, schizophrenia, or schizoaffective disorder. All participants were rated on positive and negative symptom rating scales, from which three symptom dimensions were obtained. Symptom dimensions were not significantly related to ratings of symptom severity or mental status examination scores. Disorganized symptoms were correlated with a wide range of impairments on nearly all subscale measures of social cognition. Negative symptoms were correlated with lower ratings of capacity for emotional investment, complexity of representations, and integration of episodes. Psychoticism was associated with negative affect tone. Diagnostic categories were not related to social cognitive impairments independent of estimates of premorbid level of cognitive function. Evidence of syndromal differences suggests that heterogeneity of variance in studies of functioning of schizophrenic patients can be reduced by inclusion of symptom dimensions.

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Section: Methodsmentioning

confidence: 99%

Social Cognition and Symptom Dimensions

Shean

Murphy²,

Meyer³

2005

The Journal of Nervous and Mental Disease

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“…They may merely reflect different combinations o f the neuroleptic-responsive and neuro leptic-resistant components of the disease process which are differentially af fected by the anticholinergic agents. Considering that the nuclear, especially hebephrenic, forms o f schizophrenic psychosis usually have an early onset and often long periods o f premorbid maladjustment (8,30), it is possible that longi tudinal factors, such as the beginning of the disease process in relation to indi vidual growth and the types o f distortions in ontogenesis thus produced, deter mine some o f the systematic differences between schizophrenics.…”

Section: Discussionmentioning

confidence: 99%

Nosological and Prognostic Distinctions in Schizophrenia: Pharmacological Validation in Terms of Therapeutic Antagonism between Anticholinergic Anti-Parkinsonism Drugs and Neuroleptics

Singh¹,

Kay²

1978

Neuropsychobiology

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In studying the relationships between anticholinergic-neuroleptic interactions and the nosological and prognostic distinctions in schizophrenia, we have shown that these distinctions have clinicopathological meaning. The countertherapeutic anticholinergic effects seemed to be particularly evident in the good outcome, schizophreniform cases and differentiated between the three diagnostic subtypes. Such effects were most conspicuous in the catatonics who also had the most favorable prognosis, while the paranoids differed from others in not only showing the least anticholinergic effects but also in not conforming to the relationship between these effects and prognosis. The findings are briefly considered in relation to those with wheat gluten which has also been shown to be a countertherapeutic factor in schizophrenia in another study.

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“…Gecikmiş prodrom belirtilerini ortaya koyarak bir iki yıl içinde şizofreniye çevirecek bireyleri yakalar. Yirmiyedi maddeden ve 7 alt ölçekten oluşur; 1. pozitif belirtiler (sıra dışı düşünce içeriği, algısal anomaliler, ve dezorganize konuşma), 2. bilinç değişikliği/dikkat (ör, öznel deneyimler), 3. duygusal rahatsızlık, 4. negatif belirtiler (ör, aloji), 5. davranış değişikliği (ör, sosyal izolasyon), 6. motor/fiziksel değişiklikler (ör, bozuk motor işlevsellikle ilgili öznel yakınmalar), 7. genel psikopatoloji (ör, mani).…”

Section: Bonn Temel Belirtilerin Değerlendirilmesi öLçeği (Bonn Scaleunclassified

Şizofreni ve Diğer Psikozlarda Risk Sendromları ve Risk Belirlenmesinde Kullanılan Ölçekler

Çakmak¹,

Bal²,

Tamam³

et al. 2015

Arşiv Kaynak Tarama Dergisi

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Schizophrenia is a chronic disorder leading to lifelong deterioration of social and vocational functioning. Prodromal period, designates the time interval starting with emerging nonspecific signs and deficits and extending up to presentation of distinct and ongoing schizophrenic symptoms, is observed in most of schizophrenia patients. In schizophrenia, poor premorbid adjustment leads to a worse prognosis and thus early detection and intervention is required in prodromal period. To this end, under the heading of risk factors for schizophrenia and psychosis, classification and scales to determine the risk are being utilized. Most frequently used scales are; Bonn Scale for the Assessment of Basic Symptoms (BSABS), Comprehensive Assessment of At-Risk Mental States (CAARMS), Structured Interview for Psychosis-Risk Syndromes (SIPS). Through the light of these latest developments, recent edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) added psychosis risk syndrome or attenuated psychosis syndrome to indicate risk of transition to psychosis. These approaches revealed that the risk of progression to psychosis was not reliably correlated with fulfilled criteria, but abscence of criteria credibly predicted the unlikelihood of psychosis emergence. Evidently, concomitant premorbid features and prodromal symptoms significantly increase the risk of progression to psychosis and schizophrenia in comparison to normal population. Nevertheless, specification and elaboration of risk criteria will enhance reliability of risk determination.

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Premorbid asocial adjustment and prognosis in schizophrenia

Cited by 238 publications

References 30 publications

Social Cognition and Symptom Dimensions

Social Cognition and Symptom Dimensions

Nosological and Prognostic Distinctions in Schizophrenia: Pharmacological Validation in Terms of Therapeutic Antagonism between Anticholinergic Anti-Parkinsonism Drugs and Neuroleptics

Şizofreni ve Diğer Psikozlarda Risk Sendromları ve Risk Belirlenmesinde Kullanılan Ölçekler

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