Premorbid Asocial Adjustment and Outcome in Schizophrenia

Drues, J; Hargreaves, William A.; Glick, Ira D.; Klein, Donald F.

doi:10.1097/00005053-197812000-00009

Cited by 5 publications

(1 citation statement)

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“…Associations between premorbid factors and clinical variables, both at onset and later in the illness course, have been reported by numerous studies. Many of these have demonstrated an association among the presence and severity of premorbid symptoms and an insidious or gradual mode of onset, a more chronic clinical course, and a poorer outcome of illness (Gittelman-Klein and Klein 1969; Bromet et al 1974; Drues et al 1978; Farmer et al 1983; Knesevich et al 1983; Kay and Lindenmayer 1987; Keefe et al 1989; Bartko et al 1990; Jorgensen and Parnas 1990; Fenton and McGlashan 1991; Addington and Addington 1993). Furthermore, better premorbid history has been associated with older age at onset of illness, later age of first neuroleptic use, and later age at first hospitalization (Haas and Sweeney 1992).…”

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confidence: 99%

Premorbid Functioning in Schizophrenia: Relation to Baseline Symptoms, Treatment Response, and Medication Side Effects

Strous

Alvir²,

Robinson

et al. 2004

Schizophrenia Bulletin

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Impaired premorbid functioning prior to the onset of acute psychosis has frequently been noted in schizophrenia. This study examined retrospectively the premorbid status of patients in their first episode of psychosis in order to determine relationships with baseline symptoms, treatment response, and medication side effects. One hundred eleven schizophrenic and schizoaffective patients participating in a large prospective study of first episode schizophrenia were evaluated with the Premorbid Adjustment Scale (PAS). Premorbid functioning in males became progressively worse over time. Deficit state patients exhibited worse premorbid functioning. A third of patients exhibited sustained poor premorbid functioning. At various developmental stages, lower "sociability and withdrawal" scores correlated with increased time to treatment response, more severe negative symptoms, increased drug-induced parkinsonism, and deterioration of premorbid functioning. Various mean PAS scores predicted susceptibility to tardive dyskinesia. Our findings suggest that prior to acute psychosis onset there are certain behavioral precursors reflected in premorbid functioning that may predict subsequent illness manifestations. Measures of premorbid functioning indicate that disease pathogenesis is manifest, albeit more subtly, prior to presentation of first psychotic symptoms.

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