Premorbid adjustment predictors of cognitive dysfunction in schizophrenia

Stefanatou, Pentagiotissa; Karatosidi, C.S.; Tsompanaki, Evgenia; Kattoulas, Emmanouil; Stefanis, Nicholas C.; Smyrnis, Nikolaos

doi:10.1016/j.psychres.2018.06.029

Cited by 22 publications

(20 citation statements)

References 69 publications

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“…Furthermore, levels of academic achievement and social interactions prior to disease onset during adolescence are associated with the degree of impairment in working memory and executive functioning during later phases of SZ (refs. [49][50][51] ). This indicates that socializing and cognitive challenges can positively influence cognition during the course of SZ.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, higher rates of sedentary behavior, less physical activity, and decreased sociability in adolescents at high risk to develop SZ correlate with cognitive symptoms in later stages of SZ (refs. [46][47][48][49][50][51] ). Based on these findings, we applied an environmental enrichment paradigm in order to favorably influence the development of OLs, myelination, and cognitive flexibility in the APO-SUS rat model.…”

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confidence: 99%

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Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia

et al. 2020

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Impaired cognitive functioning is a core feature of schizophrenia, and is hypothesized to be due to myelination as well as interneuron defects during adolescent prefrontal cortex (PFC) development. Here we report that in the apomorphine-susceptible (APO-SUS) rat model, which has schizophrenia-like features, a myelination defect occurred specifically in parvalbumin interneurons. The adult rats displayed medial PFC (mPFC)-dependent cognitive inflexibility, and a reduced number of mature oligodendrocytes and myelinated parvalbumin inhibitory axons in the mPFC. In the developing mPFC, we observed decreased myelin-related gene expression that persisted into adulthood. Environmental enrichment applied during adolescence restored parvalbumin interneuron hypomyelination as well as cognitive inflexibility. Collectively, these findings highlight that impairment of parvalbumin interneuron myelination is related to schizophrenia-relevant cognitive deficits.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia

et al. 2020

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“…Studies have confirmed the association between premorbid adjustment and cognitive impairment and possible role of premorbid adjustment on the capacity to recover from cognitive deficits. [16,17] It may indicate that males may need earlier clinical attention and more aggressive intervention in case of poorer premorbid adjustment compared to females. Main strength of present study was modified premorbid adjustment scale in which premorbid period was clearly defined as one year before onset of illness so that prodromal period of illness which is now regarded sometimes as part of illness was excluded clearly.…”

Section: Discussionmentioning

confidence: 99%

Gender Difference in Premorbid Adjustment in Schizophrenia- A Comparative Study

Munda¹

2019

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Introduction: Schizophrenia is a severe mental disorder and focusing on factors at period before the onset of disorder would provide ample opportunity for detection and intervention of individuals who later develop schizophrenia. Materials and Methods: A cross sectional study was conducted to compare premorbid adjustment in male and female patients of schizophrenia. 25 make and 25 female subjects were selected by purposive sampling and their family members were interviewed. Qualitative analysis was carried out to identify various factors. Results: Male patients of schizophrenia had earlier age of onset and premorbid adjustment during all stages of assessment-childhood (upto 11years), early adolescence (12-15 years), late adolescence (16-18 years) and adult (above 19 years) and total premorbid adjustment was found significantly poorer in males. Conclusions: There is significant difference in premorbid adjustment in male and female patients of schizophrenia. The difference started from childhood and persisted upto adult stage.

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“…Impairments in both social and academic PA have been extensively documented in adult patients with SZ [6,[11][12][13][14][15][16][17], bipolar disorder [11,18], and patients with first-episode psychosis (FEP) [19,20]. Importantly, PA abnormalities among patients with psychotic disorders, particularly social maladjustment, may represent a reliable predictor of unfavorable long-term clinical outcomes and enduring negative symptoms [21][22][23][24][25][26][27], cognitive dysfunction [28], and inadequate treatment response [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response

et al. 2020

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Background. Premorbid adjustment (PA) abnormalities in psychotic disorders are associated with an earlier age at onset (AAO) and unfavorable clinical outcomes, including treatment resistance. Prior family studies suggest that familial liability, likely reflecting increased genetic risk, and socioeconomic status (SES) contribute to premorbid maladjustment. However, their joint effect possibly indicating gene–environment interaction has not been evaluated. Methods. We examined whether family history of psychosis (FHP) and parental SES may predict PA and AAO in unrelated cases with first-episode psychosis (n = 108) and schizophrenia (n = 104). Premorbid academic and social functioning domains during childhood and early adolescence were retrospectively assessed. Regression analyses were performed to investigate main effects of FHP and parental SES, as well as their interaction. The relationships between PA, AAO, and response to antipsychotic medication were also explored. Results. Positive FHP associated with academic PA difficulties and importantly interacted with parental SES to moderate social PA during childhood (interaction p = 0.024). Positive FHP and parental SES did not predict differences in AAO. Nevertheless, an earlier AAO was observed among cases with worse social PA in childhood (β = −0.20; p = 0.005) and early adolescence (β = −0.19; p = 0.007). Further, confirming evidence emerged for an association between deficient childhood social PA and poor treatment response (p = 0.04). Conclusions. Familial risk for psychosis may interact with parental socioeconomic position influencing social PA in childhood. In addition, this study supports the link between social PA deviations, early psychosis onset, and treatment resistance, which highlights premorbid social functioning as a promising clinical indicator.

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Premorbid adjustment predictors of cognitive dysfunction in schizophrenia

Cited by 22 publications

References 69 publications

Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia

Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia

Gender Difference in Premorbid Adjustment in Schizophrenia- A Comparative Study

Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response

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