Prematurity among insulin‐requiring diabetic gravid women

Mf, Greene; Jw, Hare; Krache, M; Phillippe, Mark; Va, Barss; Dh, Saltzman; Nadel, A.; Younger,; Heffner, Linda J.; Scherl, J. Elizabeth

doi:10.1016/0020-7292(90)90731-y

Cited by 8 publications

(10 citation statements)

References 12 publications

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“…The rate of indicated preterm delivery was 11.9% in this study, which is similar to the incidence in previous reports 6–8 . It has been reported that progression of nephropathy, pre‐eclampsia and an HbA1C value of 7% or more at delivery are significantly associated with an increased likelihood of indicated preterm delivery 8 .…”

Section: Discussionsupporting

confidence: 88%

“…Greene et al . reported that pre‐eclampsia was the single most important cause of preterm delivery in diabetic patients 6 . In a composite group of overtly diabetic subjects, the incidence of pre‐eclampsia/superimposed pre‐eclampsia was higher than that in control pregnancies 3,7,21,22 .…”

Section: Discussionmentioning

confidence: 97%

“…In general, cases of preterm delivery may be divided into two categories, spontaneous (preterm labour or rupture of membranes) and indicated preterm delivery (by maternal and/or fetal factors) 5 . Preterm delivery in diabetic women is most often indicated, because it is primarily related to the increased incidence of pre‐eclampsia in patients with DM 6,7 . However, the precise factors that predispose women to preterm delivery in this population remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors associated with preterm delivery in women with pregestational diabetes

Matsushita¹,

Matsuda²,

Makino³

et al. 2008

J of Obstet and Gynaecol

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors associated with preterm delivery in women with pregestational diabetes

Matsushita¹,

Matsuda²,

Makino³

et al. 2008

J of Obstet and Gynaecol

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“…One distinctive aspect of the present mouse model is the possibility of studying the development of gestational complications in animals submitted to long‐term diabetes prior to pregnancy, thus simulating the human condition, when pregnancy occurs several years after the onset of type 1 diabetes. It is known that the development of diabetic complications in human pregnancy is directly related to the severity and the duration of this pathology (White 1974; Greene et al. 1989; Garner 1995; Gonzalez‐Gonzalez et al.…”

Section: Discussionmentioning

confidence: 99%

Effects of long‐term diabetes on the structure and cell proliferation of the myometrium in the early pregnancy of mice

Favaro

Salgado

Raspantini

et al. 2010

Int J Experimental Path

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It is known that the development of diabetic complications in human pregnancy is directly related to the severity and the duration of this pathology. In this study, we developed a model of long-term type 1 diabetes to investigate its effects on the cytoarchitecture, extracellular matrix and cell proliferation during the first adaptation phase of the myometrium for pregnancy. A single dose of alloxan was used to induce diabetes in mice prior to pregnancy. To identify the temporal effects of diabetes the mice were divided into two groups: Group D1 (females that became pregnant 90-100 days after alloxan); Group D2 (females that became pregnant 100-110 days after alloxan). Uterine samples were collected after 168 h of pregnancy and processed for light and electron microscopy. In both groups the histomorphometric evaluation showed that diabetes promoted narrowing of the myometrial muscle layers which was correlated with decreased cell proliferation demonstrated by PCNA immunodetection. In D1, diabetes increased the distance between muscle layers and promoted oedema. Contrarily, in D2 the distance between muscle layers decreased and, instead of oedema, there was a markedly deposition of collagen in the myometrium. Ultrastructural analysis showed that diabetes affects the organization of the smooth muscle cells and their myofilaments. Consistently, the immunoreaction for smooth muscle α-actin revealed clear disorganization of the contractile apparatus in both diabetic groups. In conclusion, the present model demonstrated that long-term diabetes promotes significant alterations in the myometrium in a time-sensitive manner. Together, these alterations indicate that diabetes impairs the first phenotypic adaptation phase of the pregnant myometrium.

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“…The Royal College of Obstetricians and Gynaecologists has recommended antenatal steroid usage in all cases in which there is a possibility of neonatal RDS [6]. In diabetic women, preterm delivery and RDS are both more frequent than in the general population [3,7]. Dexamethasone use is therefore likely to be greater in diabetic women.…”

Section: Discussionmentioning

confidence: 99%

A protocol for improved glycaemic control following corticosteroid therapy in diabetic pregnancies

Kaushal¹,

Gibson²,

Railton³

et al. 2003

Diabetic Medicine

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Prematurity among insulin‐requiring diabetic gravid women

Cited by 8 publications

References 12 publications

Risk factors associated with preterm delivery in women with pregestational diabetes

Risk factors associated with preterm delivery in women with pregestational diabetes

Effects of long‐term diabetes on the structure and cell proliferation of the myometrium in the early pregnancy of mice

A protocol for improved glycaemic control following corticosteroid therapy in diabetic pregnancies

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