Premature sebaceous hyperplasia of nipple and areola

Gao, Jian; Liu, Ling; Li, Chunying; Gao, Tianwen

doi:10.1111/j.1365-4632.2009.04440.x

Cited by 2 publications

(5 citation statements)

References 3 publications

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“…[1][2][3][4][5][6][7][8][9][10][11] We have also not found any case of association of areolar sebaceous hyperplasia and ipsilateral breast carcinoma. Glazebrook et al 33 described 2 cases in which breast carcinoma mimicked an areolar dermal lesion on sonography, but this appearance was due to dermal infiltration by the carcinoma, whereas the histopathologic study demonstrated no adnexal or epidermal alterations.…”

Section: Discussionmentioning

confidence: 74%

“…Although for some, it would be a hyperplasia of Montgomery tubercles, 5 for others, it would be a true hyperplasia of sebaceous glands, unrelated to Montgomery tubercles. 2,4,6 It is remarkable how, in 2 published cases, the areolar hyperplasia appeared after giving birth: in an unilateral presentation in one case 11 and bilaterally in the other. 1 This type of phenomenon could be related to a hyperplasia of the Montgomery tubercles, which is common in women after delivery and during lactation.…”

Section: Discussionmentioning

confidence: 99%

“…We have found 12 cases published in the literature, both in women and men. [1][2][3][4][5][6][7][8][9][10][11] Most of these cases were not associated with any relevant pathology.…”

Section: Introductionmentioning

confidence: 99%

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Areolar Sebaceous Hyperplasia With Underlying Primary Duct Carcinoma of the Breast in a Woman With Donohue Syndrome (Leprechaunism)

Fernández-Flores¹,

Valerdiz²,

Crespo³

et al. 2012

The American Journal of Dermatopathology

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Areolar hyperplasia is only reported when exaggerated, and even so, exaggerated areolar sebaceous hyperplasia is rare. We have recently seen a case of areolar sebaceous hyperplasia in a 32-year-old woman with Donohue syndrome (leprechaunism), who also had an invasive ductal carcinoma in the same breast. The patient showed typical "elfin-like" face with wide nostrils and thick lips, large and low-set ears, and dysplastic nails. The areola showed a yellowish thickened plaque of 5-cm diameter that corresponded to a hyperplasia of the sebaceous glands. Immunohistochemistry for the mismatch repair proteins (MLH1, MSH2, MSH6, and PMS2) was performed on the sebaceous hyperplasia and on the breast carcinoma, and no lack of expression of the markers was evidenced. We have found no other reported case of areolar sebaceous hyperplasia either in cases of breast carcinoma or in cases of leprechaunism.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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Areolar Sebaceous Hyperplasia With Underlying Primary Duct Carcinoma of the Breast in a Woman With Donohue Syndrome (Leprechaunism)

Fernández-Flores¹,

Valerdiz²,

Crespo³

et al. 2012

The American Journal of Dermatopathology

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“…The more frequent clinical presentation of ASH is a yellowish plaque/papula‐like or a diffuse areola thickening/swelling with multilobular involvement. In only one case, did the lesion show spadiceous papules and peduncolated nodules with a verruciformis aspect . In eight cases, there was a bilateral presentation (5F and 3M), whereas in the other seven, including ours, the presentation was unilateral (4F and 3M).…”

mentioning

confidence: 66%

“…In the course of the years, few other cases of bilateral and unilateral ASH in both genders have been reported and all on histological samples.…”

mentioning

confidence: 99%