Premature rupture of the membranes between 20 and 25 weeks' gestation: Role of amniotic fluid volume in perinatal outcome

Hadi, Hamid A.; Hodson, Charles A.; Strickland, Diana

doi:10.1016/s0002-9378(94)70109-1

Cited by 115 publications

(62 citation statements)

References 12 publications

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“…4,16,17 To conclude, we have demonstrated that the treatment with transabdominal amnioinfusion has resulted in significant prolongation of pregnancy. Our sample size was too small to be conclusive and further larger studies are needed to confirm our encouraging results.…”

Section: Discussionmentioning

confidence: 70%

Transabdominal amnioinfusion in preterm premature rupture of membranes: a randomised controlled trial

Tranquilli

Giannubilo

Bezzeccheri

et al. 2005

BJOG

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Objective To evaluate the role of transabdominal amnioinfusion in improving the perinatal outcomes of pregnancies complicated by preterm premature rupture of membranes (pPROM). Design A randomised controlled trial.Setting A teaching hospital in Italy, obstetric unit.Population Women with singleton pregnancies complicated by pPROM, between 24 þ 0 and 32 þ 6 weeks of gestation. Methods Patients were randomised 24 hours after admission to our referral hospital, to expectant management with transabdominal amnioinfusion or expectant management only. Main outcome measures The effects of transabdominal amnioinfusion on pPROM -delivery interval and on perinatal outcomes. Results Of the 65 women with pPROM 34 met the inclusion criteria. Seventeen women were assigned to amnioinfusion (the amnioinfusion group) and the other 17 to expectant management. Compared with the control group (median: 8 days; range: 3 -14), the pPROM -delivery period was significantly longer in women who underwent amnioinfusion (median: 21 days; range: 15-29) (P < 0.05). Women with amnioinfusion were less likely to deliver within seven days since pPROM (RR: 0.18; range: 0.04 -0.69 95% CI) or within two weeks (RR: 0.46; range: 0.21 -1.02 95% CI). In the amnioinfusion group the neonatal survival was significantly higher at each gestational age (P < 0.01, Yates's correction for Log Rank Test) with a reduction in pulmonary hypoplasia. Conclusions We demonstrated that compared with standard expectant management the treatment with transabdominal amnioinfusion after pPROM resulted in significant prolongation of pregnancy and better neonatal outcomes.

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Section: Discussionmentioning

confidence: 70%

Transabdominal amnioinfusion in preterm premature rupture of membranes: a randomised controlled trial

Tranquilli

Giannubilo

Bezzeccheri

et al. 2005

BJOG

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“…4 Studies have suggested that oligohydramnios is the most important predictor of perinatal mortality in very early PPROM and that adequate residual amniotic fluid plays a critical role in determining the prevalence of pulmonary hypoplasia. [4][5][6][7] Oligohydramnios is also said to be associated with a higher risk of chorioamnionitis and neonatal infection. 5 Adequate amniotic fluid volumes, on the other hand, are said to be associated with better outcomes in pregnancies affected by very early PPROM.…”

Section: Chapter 1 Background and Rationalementioning

confidence: 99%

Amnioinfusion in preterm premature rupture of membranes (AMIPROM): a randomised controlled trial of amnioinfusion versus expectant management in very early preterm premature rupture of membranes – a pilot study

Roberts

Vause

Martin

et al. 2014

Health Technology Assessment

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“…[1][2][3] Amnioinfusion is the only approach that has been evaluated by independent investigators in nonrandomized series and it has been shown to lead to higher perinatal survival rates and lower incidence of pulmonary hypoplasia compared with expectant management. [1][2][3][4][5][6] A recent randomized study 7 confirmed a significant prolongation of pregnancy in cases managed with amnioinfusion.…”

Section: Introductionmentioning

confidence: 94%

Amnioinfusion in preterm PROM: effects on amnion and cord histology

et al. 2007

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Objective: To investigate the effects of transabdominal amnioinfusion (TA) on the histology of amnion (A) and umbilical cord (UC).Study Design: From a cohort of 56 singleton pregnancies with premature rupture of membranes (PROM) at p24.6 weeks, we excluded those who did not develop severe oligohydramnios (n ¼ 12). Of the 44 patients, 29 consented to TA and 15 declined the procedure. TA was performed with normal saline solution.Result: Women who consented to TA underwent a median of three procedures had a gestational age at PROM of 18.7 weeks and at delivery of 26.1 weeks, with a latency of 50 days. Compared with subjects who declined the procedure, TA had a beneficial effect on clinical variables, mediated primarily by a longer latency. TA was not associated with identifiable effects on the histologic features of A or UC. Conclusion:A and UC histology is not significantly affected by exposure to saline solution even for prolonged periods of time.

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Premature rupture of the membranes between 20 and 25 weeks' gestation: Role of amniotic fluid volume in perinatal outcome

Cited by 115 publications

References 12 publications

Transabdominal amnioinfusion in preterm premature rupture of membranes: a randomised controlled trial

Transabdominal amnioinfusion in preterm premature rupture of membranes: a randomised controlled trial

Amnioinfusion in preterm premature rupture of membranes (AMIPROM): a randomised controlled trial of amnioinfusion versus expectant management in very early preterm premature rupture of membranes – a pilot study

Amnioinfusion in preterm PROM: effects on amnion and cord histology

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