Premature peripheral vascular disease: clinical profile and abnormal lipid peroxidation

Harris, Linda M.; Armstrong, Donald; Browne, Richard W.; Aljada, Ahmad; Peer, Richard M.; Upson, James F.; Pillai, L; Curl, G. Richard; Ricotta, John J.

doi:10.1016/s0967-2109(97)00123-3

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…Similarly, levels of LDL are higher and HDL levels are lower in patients with lower extremity PAD than in age-matched controls (40,54,(56)(57)(58). Elevated levels of triglycerides have been reported to be associated with lower extremity PAD in some studies but not in others (59)(60)(61)(62)(63). The relationship between hypertriglyceridemia and lower extremity PAD usually remains intact, albeit with some interstudy variability, when adjusted for the presence of other risk factors (3,35,52).…”

Section: The Vascular Physical Examinationmentioning

confidence: 99%

ACC/AHA 2005 Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): A Collaborative Report from the American Association for Vascular Surgery/Society for Vascular Surgery,⁎Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients

Hirsch¹,

Haskal²,

Hertzer³

et al. 2006

Journal of the American College of Cardiology

1,286

2,210

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Section: The Vascular Physical Examinationmentioning

confidence: 99%

ACC/AHA 2005 Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): A Collaborative Report from the American Association for Vascular Surgery/Society for Vascular Surgery,⁎Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients

Hirsch¹,

Haskal²,

Hertzer³

et al. 2006

Journal of the American College of Cardiology

1,286

2,210

View full text Add to dashboard Cite

Section: Hirsch Et Al 2005 Acc/aha Practice Guidelinesmentioning

confidence: 99%

ACC/AHA 2005 Practice Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic)

Hirsch

Haskal²,

Hertzer³

et al. 2006

Circulation

2,929

1,088

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“…Assessment of oxidative stress status of patients was achieved by determination of the thiobarbituric acid reactive substances in the fractionated lipoproteins. [15] Three milliliter serum was mixed with 100 μL sodium heparinate, 150 μL manganese chloride (10%), briefl y vortex the mixture, then incubated for 10 min at room temperature aft er that centrifugation at 15000 rpm for 15 min. The pellet was separated from the supernatant and suspended in 3 mL sodium chloride (0.9%).…”

Section: Determination Of Lipid Peroxidesmentioning

confidence: 99%

Role of nitrosative and oxidative stress in neuropathy in patients with type 2 diabetes mellitus

Al-Nimer

Al-Ani

Ali

2012

Journal of Neurosciences in Rural Practice

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Objectives:Evidences of oxidative and/or nitrosative stress in type 2 diabetes mellitus were demonstrated in experimental and human studies. This study is aimed to assess the serum peroxynitrite and oxidized lipoproteins in patients with type 2 diabetes mellitus presented with clinical and laboratory evidences of peripheral neuropathy.Materials and Methods:Eighty four patients with type 2 diabetes mellitus (51 of them had neuropathy) and 31 apparent healthy subjects were studied in the unit of neurophysiology at the University Hospital of Medical College, Al-Nahrin University in Baghdad, Iraq. Neuropathy total symptom score (NTSS), neuropathy impairment score in the lower leg (NIS-LL), and nerve conduction velocity of sensory (ulnar and sural) and motor (ulnar and common peroneal) nerves were used to assess the neuropathy. Fasting venous blood was obtained from each participant for the determination of serum glucose and oxidized lipoproteins.Results:The electrophysiology study revealed significant decrease in conduction velocity of ulnar (sensory and motor components), sural, and common peroneal nerves in diabetic neuropathy compared to diabetics without neuropathy and healthy subjects. Significant high level of serum peroxynitrite was found in diabetic patients with or without neuropathy compared with non-diabetics. The changes in serum-oxidized lipoproteins in patients with diabetics with or without neuropathy were non-significantly differed from healthy subjects. Neither nitrosative stress nor oxidative stress indices correlated with the variables that are related to the neuropathy.Conclusion:It concludes that evidence of nitrosative and to less extent the oxidative stress is associated with neuropathy in type 2 diabetes mellitus and their indices not correlated with variables related to neuropathy.

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Premature peripheral vascular disease: clinical profile and abnormal lipid peroxidation

Cited by 9 publications

References 20 publications

ACC/AHA 2005 Practice Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic)

Role of nitrosative and oxidative stress in neuropathy in patients with type 2 diabetes mellitus

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