Premature Ovarian Insufficiency: Phenotypic Characterization Within Different Etiologies

Zhang, Huihui; Ke, Hanni; Zhang, Jiangtao; Cheng, Lei; Liu, Yi‐Xun; Qin, Yingying; Chen, Zi-Jiang

doi:10.1210/jc.2016-3960

Cited by 98 publications

(72 citation statements)

References 34 publications

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“…POI poses a considerable risk to female reproductive health [ 1 , 2 ]. As a principal factor in female infertility, POI is diagnosed and characterized by oligomenorrhea or amenorrhea for at least four months prior to 40 years of age, and POI patients exhibit increased levels of FSH (> 25 U/L between two detections) [ 3 , 4 ]. These changes may lead to increased risk of osteoporosis, emotional issues or cardiovascular diseases; ~1% of woman worldwide are affected by POI, and etiological and pathophysiological mechanisms underlying its development have yet not been fully known [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling

Feng

Tan

2018

Stem Cell Rev and Rep

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POI is characterized by “absent not abnormal” menstruation with hormonal disorders in woman younger than 40 years of age, and etiological and pathophysiological mechanisms underlying the POI development have not been clearly defined. Recently, due to advantages such as abundant sources and non-invasive methods of harvest, MenSCs have been emerging as a promising treatment strategy for the recovery of female reproductive damage. Here, we demonstrated that MenSCs graft in POI mice after CTX treatment could restore ovarian function by regulating normal follicle development and estrous cycle, reducing apoptosis in ovaries to maintain homeostasis of microenvironment and modulating serum sex hormones to a relatively normal status. Moreover, MenSCs participated in the activation of ovarian transcriptional expression in ECM-dependent FAK/AKT signaling pathway and thus restored ovarian function to a certain extent. MenSCs transplantation was proved to be an effective way to repair ovarian function with low immunogenicity, suggesting its great potential for POI treatment. Electronic supplementary material The online version of this article (10.1007/s12015-018-9867-0) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling

Feng

Tan

2018

Stem Cell Rev and Rep

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“…POI is one of the most common reproductive disorders. It has been reported that the incidence of POI is approximately 1% in fertile women and is associated with immune factors in 30% of cases (Jiao et al, 2017). The complex and varied etiologies of POI have resulted in a lack of effective treatment (Laven, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Fu et al, 2017;Jagarlamudi, Reddy, Adhikari, & Liu, 2011). In recent years, according to some study results, autoimmunity is responsible for ∼4-30% of POI cases (Ebrahimi & Akbari Asbagh, 2015;Jiao et al, 2017).…”

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confidence: 99%

Adoptive transfers of CD4⁺CD25⁺ Tregs partially alleviate mouse premature ovarian insufficiency

Liú

Chi-bing

et al. 2020

Molecular Reproduction Devel

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This study was designed to investigate the protective effect of CD4+CD25+ regulatory T cells (Tregs) against zona pellucida glycoprotein 3 peptide (pZP3) immunization‐induced premature ovarian insufficiency (POI) in mice. A mouse POI model was induced by two subcutaneous injections of pZP3 (50 nmol/L). Mice in the pZP3‐Treg group were intraperitoneally injected with 5 × 105 CD4+CD25+ Tregs after the POI model was established. Sex hormone levels, follicle numbers, apoptotic events, and the Akt/FOXO3a signaling pathway molecules in the ovaries were assessed. Compared with control group, the weight of ovaries in both pZP3 group and pZP3‐Treg group was decreased and no difference was found between them. The number of follicles in the Treg transferred mice, like in pZP3 group, was significantly reduced compared to the control group, but showed a modest improvement when compared the pZP3 group alone. Significantly lower serum concentrations of follicle‐stimulating hormone, luteinizing hormone, and anti‐zona pellucida antibodies (AZPAbs) were found, while the concentrations of estradiol and anti‐Mullerian hormone increased. In mechanism, Treg cell transfer to ZP3 treated mice restored the levels of Caspase3 to control levels, and partially restored Bax, however, had no effect on Bcl‐2. Moreover, Treg cell transfer to ZP3 treated mice partially restored the levels of Akt and FOXO3a, and partially restored the ratios of p‐Akt/Akt and p‐FOXO3a/FOXO3a. In conclusion, Treg cells improved some aspects of ZP3‐induced POI which may be mediate by suppressing ovarian cells apoptosis and involving the Akt/FOXO3a signaling pathway. Therefore, Treg cells may be protective against autoimmune POI.

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“…[ 5 – 7 ] In China, however, the frequency of pathogenic gene mutations in POI patients is generally <2%, although clinical diagnostic reports concerning these values are limited. [ 8 ] Common iatrogenic factors include surgery, radiotherapy, and chemotherapy. [ 9 ] Besides, Some POI patients have autoimmune diseases, and it is most related to autoimmune thyroid disease.…”

Section: Introductionmentioning

confidence: 99%

A comparison of the efficacy and safety of complementary and alternative therapies for premature ovarian insufficiency

Zhang

et al. 2020

Medicine

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Background: With the increase in the incidence of premature ovarian insufficiency (POI) over the years, the ovarian function has become one of the integral aspects of research in reproductive medicine today. POI seriously affects the physical and mental health of women, especially reproductive health. Studies show both complementary and alternative therapies to be effective in treating POIs. However, consistency in conclusions is still far-fetched. In light of this, we will carry out a study to evaluate the effectiveness and safety of complementary and alternative therapies for POIs. We therefore develop a study protocol for a proposed network meta-analysis (NMA) and systematic review on POI. Methods: The following electronic bibliographic database will be searched: VIP database, Wanfang database, Chinese National Knowledge Infrastructure (CNKI), The Cochrane Library, PubMed, EMBASE and Web of Science from inception till 31 December 2019. A search at the World Health Organization (WHO) International Clinical Trials Registry Platform will also be done. Subsequently, the searched data will undergo independent screening, retrieving, and risk of bias assessment by 2 reviewers. Analysis will be performed on included studies using the NMA technique. Next, the primary outcomes will be compared using ADDIS 1.16.5 and Stata 15.0. Results: The safety and effectiveness of alternative and complementary therapies used in the treatment of POI will be compared and evaluated. Conclusion: This work will provide high-quality evidence for clinicians in the field to build on for best practices in effective interventions (complementary and alternative therapies) for POI. Ethics and dissemination: This NMA is a secondary research which based on some previously published data. Therefore, the ethical approval was not necessary. PROSPERO registration number: CRD42020163873

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Premature Ovarian Insufficiency: Phenotypic Characterization Within Different Etiologies

Abstract: Our results regarding distinct phenotypic characteristics and association with different etiologies further confirmed the high heterogeneity of POI. Additional longitudinal clinical studies and pathogenesis research are warranted.

Cited by 98 publications

References 34 publications

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling

Adoptive transfers of CD4⁺CD25⁺ Tregs partially alleviate mouse premature ovarian insufficiency

A comparison of the efficacy and safety of complementary and alternative therapies for premature ovarian insufficiency

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Premature Ovarian Insufficiency: Phenotypic Characterization Within Different Etiologies

Abstract: Our results regarding distinct phenotypic characteristics and association with different etiologies further confirmed the high heterogeneity of POI. Additional longitudinal clinical studies and pathogenesis research are warranted.

Cited by 98 publications

References 34 publications

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling

Adoptive transfers of CD4+CD25+ Tregs partially alleviate mouse premature ovarian insufficiency

A comparison of the efficacy and safety of complementary and alternative therapies for premature ovarian insufficiency

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Adoptive transfers of CD4⁺CD25⁺ Tregs partially alleviate mouse premature ovarian insufficiency