Premature ovarian insufficiency – novel hormonal approaches in optimizing fertility

Dikić, Svetlana Dragojević; Vasiljevic, Mladenko; Stevanovic, Aleksandar; Dikić, Srdjan; Jurisic, A.; Srbinović, L; Vujović, Svetlana

doi:10.1080/09513590.2019.1640203

Cited by 17 publications

(9 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Essentially, the BMD data are reassuring for all regimens evaluated and the choice may consider other aspects such as the need of contraception (considering the rare but existing probability of spontaneous pregnancy in some subgroups of POI (Dragojević Dikić et al, 2020)) and patient preferences and adherence. In this context, the use of COC in continuous regimen appears to be a safe and effective option to preserve bone health (Gazarra et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Hormone therapy in women with premature ovarian insufficiency: a systematic review and meta-analysis

Gonçalves

Vasconcellos

Rodrigues

et al. 2022

Reproductive BioMedicine Online

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Hormone therapy in women with premature ovarian insufficiency: a systematic review and meta-analysis

Gonçalves

Vasconcellos

Rodrigues

et al. 2022

Reproductive BioMedicine Online

View full text Add to dashboard Cite

“…However, current PAI guidelines do not recommend DHEA substitution automatically for every patient with PAI ( 37 ). Regarding patients with POI, the effect of DHEA substitution in the improvement of fertility and successful pregnancies is controversial ( 38 ). Nevertheless, since POI often presents with PAI in patients with APECED, DHEA replacement trial could be beneficial in patients with low androgen levels due to both POI and PAI.…”

Section: Discussionmentioning

confidence: 99%

Endocrine Disorders and Genital Infections Impair Gynecological Health in APECED (APS-1)

et al. 2021

View full text Add to dashboard Cite

ObjectiveIn autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) defects in the autoimmune regulator gene lead to impaired immunotolerance. We explored the effects of immunodeficiency and endocrinopathies on gynecologic health in patients with APECED.DesignCross-sectional cohort study combined with longitudinal follow-up data.MethodsWe carried out a gynecologic evaluation, pelvic ultrasound, and laboratory and microbiologic assessment in 19 women with APECED. Retrospective data were collected from previous study visits and hospital records.ResultsThe study subjects’ median age was 42.6 years (range, 16.7-65.5). Sixteen patients (84%) had premature ovarian insufficiency, diagnosed at the median age of 16.5 years; 75% of them used currently either combined contraception or hormonal replacement therapy. In 76% of women, the morphology and size of the uterus were determined normal for age, menopausal status, and current hormonal therapy. Fifteen patients (79%) had primary adrenal insufficiency; three of them used dehydroepiandrosterone substitution. All androgen concentrations were under the detection limit in 11 patients (58%). Genital infections were detected in nine patients (47%); most of them were asymptomatic. Gynecologic C. albicans infection was detected in four patients (21%); one of the strains was resistant to azoles. Five patients (26%) had human papillomavirus infection, three of which were high-risk subtypes. Cervical cell atypia was detected in one patient. No correlation between genital infections and anti-cytokine autoantibodies was found.ConclusionsOvarian and adrenal insufficiencies manifested with very low androgen levels in over half of the patients. Asymptomatic genital infections, but not cervical cell atypia, were common in female patients with APECED.

show abstract

“…A diagnosis of POI does not exclude the possibility of ovarian activity and ovulation, with approximately a 5% chance of natural conception. Use of HT might actually increase the chance of pregnancy slightly through suppression of high FSH and LH levels, which may otherwise downregulate ovarian receptors and cause premature luteinization of follicles, thus facilitating ovulation of any remaining oocytes 170,171 . It is therefore important that adequate contraception is used if pregnancy is not desired.…”

Section: Contraceptionmentioning

confidence: 99%

Premature ovarian insufficiency: an International Menopause Society White Paper

et al. 2020

View full text Add to dashboard Cite

The aim of this International Menopause Society White Paper on premature ovarian insufficiency (POI) is to provide the latest information regarding this distressing condition. The impact of POI has far-reaching consequences due to its impact on general, psychological, and sexual quality of life, fertility prospects, and long-term bone, cardiovascular, and cognitive health. Progress in fully understanding the etiology, diagnosis, and optimal management options has been slow thus far due to the complexity of the condition and fragmented research. Recent advances in epidemiological and genetic research have improved our understanding of this condition and randomized prospective trials are being planned to determine the intervention strategies, which will optimize quality of life and long-term well-being. The International Menopause Society has commissioned a number of experts at the forefront of their specialty to define the state of the art in the understanding of this condition, to advise on practical management strategies, and to propose future research strategies. It is hoped that a global task force will subsequently be convened in order to formulate a consensus statement across key societies, to accelerate date collection and analysis of a global POI registry, and to facilitate progress in the key defined areas of research.

show abstract

Premature ovarian insufficiency – novel hormonal approaches in optimizing fertility

Cited by 17 publications

References 22 publications

Hormone therapy in women with premature ovarian insufficiency: a systematic review and meta-analysis

Hormone therapy in women with premature ovarian insufficiency: a systematic review and meta-analysis

Endocrine Disorders and Genital Infections Impair Gynecological Health in APECED (APS-1)

Premature ovarian insufficiency: an International Menopause Society White Paper

Contact Info

Product

Resources

About