Premature ovarian failure

Vegetti, Walter; Marozzi, Anna; Manfredini, Emanuela; Testa, Giovanna; Alagna, Federica; Nicolosi, Anna Elisa; Caliari, Ilaria; Taborelli, Monica; Tibiletti, Maria Grazia; Dalprà, Leda; Crosignani, Pier Giorgio

doi:10.1016/s0303-7207(99)00224-5

Cited by 82 publications

(39 citation statements)

References 20 publications

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“…The incidence is one in 10 000 women at the age of 20, one in 1000 at the age of 30, and one in 100 by the age of 40. POF can be sporadic or familial (4-33%; Conway 1996, van Kasteren et al 1999, Vegetti et al 2000. Aside from its associated fertility problems, POF is a serious endocrine disorder and, if left untreated, can induce a twofold age-specific increase in mortality due to an increased incidence of cardiovascular disease, stroke, and osteoporosis (Snowdon et al 1989).…”

Section: Introductionmentioning

confidence: 99%

Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis

Yang

Zhou²,

Peng³

et al. 2012

Reproduction

157

122

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Recent studies implicate the regulatory function of microRNAs (miRNAs) in oocyte maturation and ovarian follicular development. Differentially expressed miRNAs are found in the plasma of premature ovarian failure (POF) patients and normal cycling women. In this study, miRNA-regulated signaling pathways and related genes were described using Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis. The effect of mir-23a on granulosa cell apoptosis was also studied by examining the protein expression of X-linked inhibitor of apoptosis protein (XIAP) and caspase-3, followed by subsequent counting of apoptotic cells after Hoechst 33258 staining. Both GO analysis and pathway analysis suggested that many signaling pathways, including the AKT signaling pathway, steroid hormone receptor signaling pathways, and others, were regulated by this group of differentially expressed miRNAs. A decrease in XIAP expression (mRNA and protein level) and caspase-3 protein levels and an increase in cleaved caspase-3 protein were observed in human ovarian granulosa cells transfected with pre-mir-23a, along with an increased occurrence of apoptosis. In conclusion, differentially expressed miRNAs in the plasma of POF patients may have regulatory effects on proliferation and apoptosis of granulosa cells by affecting different signaling pathways. Mir-23a may play important roles in regulating apoptosis via decreasing XIAP expression in human ovarian granulosa cells.

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Section: Introductionmentioning

confidence: 99%

Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis

Yang

Zhou²,

Peng³

et al. 2012

Reproduction

157

122

View full text Add to dashboard Cite

show abstract

“…The rate of premature ovarian failure (ie, menopause under the age of 40) has been estimated at 1% and is often familial. 5 Early menopause (ie, menopause between 41-44 years) is estimated to occur in approximately 5% of women. While breast cancer is more common in older women, about 1 in 200 women under the age of 40 is at risk to develop breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Chemotherapy-Induced Amenorrhea and Fertility in Women Undergoing Adjuvant Treatment for Breast Cancer

2002

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“…This is supported by the observation that women with early menopause and POF are found within the same families, suggesting a genetic relationship between early menopause and POF (15,21).…”

mentioning

confidence: 53%

Age at natural menopause is not linked with the follicle-stimulating hormone receptor region: a sib-pair study

Kok

Asselt

Peeters

et al. 2004

Fertility and Sterility

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Objective: Studies have shown that age at natural menopause is heritable. Mutations in the FSH-receptor have been identified in women with premature ovarian failure (POF) and the FSH-receptor gene may, therefore, be considered a candidate gene for (early) menopausal age. This study investigates whether there is linkage between genetic markers in the FSH-receptor region and (early) age at menopause using a sib-pair design. Design: Sib-pair based linkage analysis. Setting: Sister pairs and their first-degree family members from The Netherlands. Patient(s):The inclusion criteria for a family were natural menopause in upper or lower tail of the distribution of menopausal age in at least two sisters. A total of 126 families with at least one sib-pair were included in this study. Six polymorphic markers encompassing the FSH-receptor gene were genotyped. Intervention(s): None. Main Outcome Measure(s): Single point and multipoint logarithm of the odds (LOD) scores. Result(s):None of the markers showed evidence in favor of linkage with overall age at natural menopause or early age at natural menopause. Conclusion(s):Possibly, age at natural menopause in the more or less normal range is not part of the spectrum of phenotypes determined by mutations in the FSH-receptor gene. Alternatively, our results might be explained by genetic heterogeneity in the left tail of the distribution of menopausal age. This can limit the chance of finding a genetic locus, especially if this factor has a modest contribution to the phenotype. (Fertil Steril 2004;81:611-6.

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Premature ovarian failure

Cited by 82 publications

References 20 publications

Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis

Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis

Chemotherapy-Induced Amenorrhea and Fertility in Women Undergoing Adjuvant Treatment for Breast Cancer

Age at natural menopause is not linked with the follicle-stimulating hormone receptor region: a sib-pair study

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