Premature Luteinization: Could It Be An Early Manifestation of Low Ovarian Reserve?

Younis, Johnny S.; Haddad, Sami; Matilsky, Moshe; Ben‐Ami, Moshe

doi:10.1016/s0015-0282(97)00561-x

Cited by 60 publications

(29 citation statements)

References 23 publications

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“…Women with premature luteinization, indeed, may have higher day 3 FSH levels (Younis et al 1998(Younis et al , 2001, though there are no data to support higher intracycle levels in the literature. In this study, FSH levels during ovarian hyperstimulation were not higher in Group 3 patients.…”

Section: Discussionmentioning

confidence: 97%

Aging-related premature luteinization of granulosa cells is avoided by early oocyte retrieval

Wu¹,

Barad²,

Kushnir³

et al. 2015

Journal of Endocrinology

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Why IVF pregnancy rates decline sharply after age 43 is unknown. In this study, we compared granulosa cell (GC) function in young oocyte donors (nZ31, ages 21-29), middle-aged (nZ64, ages 30-37) and older infertile patients (nZ41, ages 43-47). Gene expressions related to gonadotropin activity, steroidogenesis, apoptosis and luteinization were examined by real-time PCR and western blot in GCs collected from follicular fluid. FSH receptor (FSHR), aromatase (CYP19A1) and 17b-hydroxysteroid dehydrogenase (HSD17B) expression were found down regulated with advancing age, while LH receptor (LHCGR), P450scc (CYP11A1) and progesterone receptor (PGR) were up regulated. Upon in vitro culture, GCs were found to exhibit lower proliferation and increased apoptosis with aging. While FSH supplementation stimulated GCs growth and prevented luteinization in vitro. These observations demonstrate age-related functional declines in GCs, consistent with premature luteinization. To avoid premature luteinization in women above age 43, we advanced oocyte retrieval by administering human chorionic gonadotropin at maximal leading follicle size of 16 mm (routine 19-21 mm). Compared to normal cycles in women of similar age, earlier retrieved patients demonstrated only a marginal increase in oocyte prematurity, yet exhibited improved embryo numbers as well as quality and respectable clinical pregnancy rates. Premature follicular luteinization appears to contribute to rapidly declining IVF pregnancy chances after age 43, and can be avoided by earlier oocyte retrieval.

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Section: Discussionmentioning

confidence: 97%

Aging-related premature luteinization of granulosa cells is avoided by early oocyte retrieval

Wu¹,

Barad²,

Kushnir³

et al. 2015

Journal of Endocrinology

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show abstract

“…In non-agonist protocols, premature luteinization is common in cases with lower ovarian reserve [3,4] where LH rise occurs despite lower response to stimulation and lower estradiol values. A deficiency of the so called gonadotropin surge attenuating factor (Gn-SAF) has been incriminated [5].…”

Section: Introductionmentioning

confidence: 99%

Does subtle progesterone rise on the day of HCG affect pregnancy rate in long agonist ICSI cycles?

Saleh

Omran

Draz

2009

J Assist Reprod Genet

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“…Therefore, to take into consideration the increase in the late follicular P level and to control for the ovarian response of each patient undergoing COH, the P/E 2 ratio was introduced by our group [10,24]. Calculation of the P/E 2 ratio was performed as follows: P (ng/mL) X 1,000/ E 2 (pg/mL).…”

Section: A Call For a New Definitionmentioning

confidence: 99%

“Premature luteinization” in the era of GnRH analogue protocols: time to reconsider

Younis

2011

J Assist Reprod Genet

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Premature Luteinization: Could It Be An Early Manifestation of Low Ovarian Reserve?

Cited by 60 publications

References 23 publications

Aging-related premature luteinization of granulosa cells is avoided by early oocyte retrieval

Aging-related premature luteinization of granulosa cells is avoided by early oocyte retrieval

Does subtle progesterone rise on the day of HCG affect pregnancy rate in long agonist ICSI cycles?

“Premature luteinization” in the era of GnRH analogue protocols: time to reconsider

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