Premature hair greying may predict reduced bone mineral density in Graves’ disease

Leary, Angelina V.; Grealy, G.; Higgins, Thomas M.; Buckley, Neil J.; Barry, D. G.; Ferriss, J. B.

doi:10.1007/bf03168823

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…Similar findings are also reported by Orr‐Walker et al, 73 In graves' disease patients, Leary et al, reported that Mean Z and T scores at the lumbar spine were significantly lower in subjects with PGH compared to control group. PGH was present in 36% of patients with Graves' patients, compared to only 25% of control women 74 . On the contrary, the “Rancho Bernardo Study”, (n = 1207) did not find any significant association between PGH and osteopenia in either men or women 32 .…”

Section: Resultsmentioning

confidence: 86%

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Premature graying of hair: Risk factors, co‐morbid conditions, pharmacotherapy and reversal—A systematic review and meta‐analysis

Mahendiratta

Sarma

Kaur

et al. 2020

Dermatologic Therapy

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Premature graying of hair (PGH) being a very common entity for which pharmacotherapy and reversibility are not properly addressed. Therefore, this systematic review was conducted to address these issues. For this relevant study were selected from various databases including PubMed, EMBASE, OVID, Web of science, Scopus, and Google Scholar till January 20, 2019. Studies which reported risk factors, co-morbid conditions associated with PGH, its pharmacotherapy and reversal were included in the study. Although many risk factors are reported in literature, smoking, vitamin deficiency (B12, folic acid, and B7), mineral deficiency (low serum calcium and serum ferritin) are found to be associated with PGH. Other important risk factors are family history of PGH, obesity, high B.P, lack of exercise, drugs, genetic syndromes, dyslipidemia, thyroid disorders, hyperuricemia, and alteration in liver function. PGH is found to be an important marker of CAD, more so in case of smoker. Among different pharmacotherapeutic management options, low grade recommendation (2A) is given to calcium pantothenate, PABA, calcium pantothenate + PABA combination. Anu-tailam is the only herbal agent evaluated in clinical research settings. Finally, treating the accompanying pathologies led to the reversal of the disease in many cases. K E Y W O R D S co-morbidities, premature graying of hair, reversal, risk factors, treatment 1 | INTRODUCTION Hair graying is a part of aging, which typically starts around 34.2 ± 9.6 years (whites) to 43.9 ± 10.3 years (in blacks). 1 Premature graying of hair (PGH) is said to occur if hair graying starts before the age of 20 (Caucasians) and 30 years in Africans. 1-4 For Indian people, a cut off range of 25 years is suggested. 1,5 DOPA oxidase positive follicular melanocytes are the primary site of pigment production. Hair color basically depends on the eumelanin Abbreviations: BMD, bone mineral density; BMI, body mass index; CAD, coronary artery disease; DBP, diastolic blood pressure; FBS, fasting blood sugar; OR, odds ratio; PABA, paraamino benzoic acid; PGH, premature graying of hair; RCT, randomized controlled trials; SBP, systolic blood pressure; TERT, telomerase reverse transcriptase. Saniya Mahendiratta and Phulen Sarma have contributed equally to this study and both are considered as first authors.

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Section: Resultsmentioning

confidence: 86%

“…under the age 50. 43,59 Other potential comorbid conditions are altered thyroid function, 37,53,77 hyperuricemia, 28 altered liver function, 1,28 osteopenia, 22,32,[73][74][75] hearing loss, 30,34 psoriasis, 23 etc.…”

Section: Discussionmentioning

confidence: 99%

Premature graying of hair: Risk factors, co‐morbid conditions, pharmacotherapy and reversal—A systematic review and meta‐analysis

Mahendiratta

Sarma

Kaur

et al. 2020

Dermatologic Therapy

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“…Premature greying may be a weak marker for reduced bone mineral density (BMD) in women with a history of Graves' disease, but it is not a marker in normal women [33]. But later studies showed no such link [34].…”

Section: Aetiopathogenesismentioning

confidence: 99%

Premature Greying of Hair (Premature Canities): A Concern for Parent and Child

Nigam¹,

Nigam²

2017

Pigmentary Disorders

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Hair goes grey with chronological aging. Premature hair greying may have significant adverse effects on the appearance, self-esteem, and socio-cultural acceptance of the affected individual. The exact aetiopathogenetic mechanism causing premature greying is still not clear and much speculative. Premature canities may appear alone as an autosomal dominant trait or it may occur in association with certain other disorders. The genes Pax3 and MITE play an important role in melanocyte stem cell maintenance and differentiation. Defective melanosomal transfer to the cortical keratinocytes or melanin incontinence due to melanocyte degeneration is also believed to contribute to greying. Despite the extensive molecular research being carried out to understand the pathogenesis of canities, treatment options still remain far from satisfactory and no effective therapy is available. Premature greying is a feature in a number of well recognised syndromes. A number of other conditions have also been observed to be associated with premature greying of hair.

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“…Isolated cases with hair color changes in association with other diseases/syndromes have been reported. Decreased production of the melanin pigment causes hair to become lighter, which was found in several medical conditions affecting hair color, such as coronary artery disease, osteopenia, and Graves disease [Eisenstein and Edelstein, 1982; Rosen et al, 1994; Leary et al, 2001]. We therefore suggested that a temporary reduction of melanin production in the fetal, but not infancy, stage through an undiscovered mechanism due to GNPTAB defects may cause the hair color change in the early infancy as observed in our patient.…”

Section: To the Editormentioning

confidence: 99%

A compound heterozygous GNPTAB mutation causes mucolipidosis II with marked hair color change in a Han Chinese baby

Chang

et al. 2011

Am. J. Med. Genet.

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Premature hair greying may predict reduced bone mineral density in Graves’ disease

Abstract: Premature greying may be a weak marker for reduced BMD in women with a history of Graves' disease, but it is not a marker in normal women.

Cited by 6 publications

References 14 publications

Premature graying of hair: Risk factors, co‐morbid conditions, pharmacotherapy and reversal—A systematic review and meta‐analysis

Premature graying of hair: Risk factors, co‐morbid conditions, pharmacotherapy and reversal—A systematic review and meta‐analysis

Premature Greying of Hair (Premature Canities): A Concern for Parent and Child

A compound heterozygous GNPTAB mutation causes mucolipidosis II with marked hair color change in a Han Chinese baby

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