Premature Ejaculation is Associated with Glycemic Control in Type 1 Diabetes

Abstract

Introduction Premature ejaculation (PE) is the most common male sexual dysfunction. Its prevalence in Type 1 diabetes is unknown. Aim The aim of this study was to assess the prevalence of PE in Type 1 diabetes and the influence of glycemic control on ejaculatory function. Methods One hundred Type 1 diabetic male patients (age < 40 years) and 51 age-matched nondiabetic control subjects were evaluated for PE. A subgroup of 30 diabetic patients (20 with PE and 10 without) were also evaluated for blood glucose variability. Main Outcome Measures The presence of PE was assessed with the premature ejaculation diagnostic tool (PEDT) and the self-estimated intravaginal ejaculatory latency time (IELT). Glucose variability was evaluated by continuous glucose monitoring for a 7-day period with a DexCom G4 CGM system: the mean amplitude of glycemic excursions (MAGEs), low (LBGI) and high (HBGI) blood glucose indices, and the standard deviation of blood glucose (BGSD) were calculated. Results PE prevalence did not differ significantly between the two groups: pathological values of the PEDT score (>8) and IELT score (<1 minute) were recorded in 24 out of 100 diabetic patients (24%) and in 12 out of 51 controls (23.5%). There were significant associations between hemoglobin A1c and the PEDT score (r = 0.27; P = 0.006) and IELT (r = −0.3; P = 0.01). In the subgroup assessed for glucose variability, the PEDT score was associated with LBGI (r = 0.43; P = 0.01), but not with BGSD (r = 0.1, P = 0.6), MAGE (r = −0.1; P = 0.4), or HBGI (r = 0.1; P = 0.6). Conclusions Our results show a similar prevalence of PE in young male patients with Type 1 diabetes and in the age-matched control population; in diabetic patients with PE, a higher glycemic variability in the hypoglycemic domain is significantly associated with the PEDT score.

Prevalence and Associated Factors of Premature Ejaculation in the Anhui Male Population in China: Evidence-Based Unified Definition of Lifelong and Acquired Premature Ejaculation

“…Premature ejaculation (PE) has been widely regarded as a common male sexual problem. 1 , 2 During the past decade, many studies have attempted to provide clearer guidelines for its definition and diagnosis. 3 , 4 , 5 Most definitions of PE consist of three parts 6 : (i) short intravaginal ejaculatory latency time (IELT); (ii) lack of perceived self-efficacy or control about the timing of ejaculation; and (iii) personal distress and interpersonal difficulty related to ejaculatory dysfunction.…”

The association between acquired premature ejaculation and metabolic syndrome in young Chinese men

“…The number of studies in this field is far from enough. Bellastella et al showed that type I diabetes was not a risk factor for PE and results from a prospective study demonstrated that PE was more prevalent in patients with diabetes (Bellastella et al., 2015; Majzoub et al., 2016). However, further studies are warranted to validate these findings.…”

Premature ejaculation: an update on definition and pathophysiology

“…It has been proposed that PE in diabetic patients may be secondary to psychogenic factors such as performance anxiety and depression or organic factors such as diabetic neuropathy, which may be implicated in the pathophysiology of PE due to the fact that potency and ejaculation depend on the integrity of the autonomic nervous system and its central and peripheral neurotransmitters 8587. Bellastella et al 88 showed that the prevalence of PE in young male patients with Type 1 diabetes was similar to an age-matched control population and in diabetic patients with PE; higher glycemic variability in the hypoglycemic domain is significantly associated with the premature ejaculation diagnostic tool (PEDT) score.…”