Premature delivery and organochlorine compounds: Polychlorinated biphenyls and some organochlorine insecticides

Wassermann, M.; Ron, M.; Bercovici, B; D, Wassermann; Cucos, Simi; Pines, Anatol

doi:10.1016/0013-9351(82)90158-x

Cited by 88 publications

(44 citation statements)

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“…However, in vitro exposure of rat uterine strips isolated from pregnant (Gestation Day 10) rats to cumulative concentrations of lindane at 10-min intervals was found to depress spontaneous contractions at 10 μM lindane and abolish contractions at 30 μM lindane (Criswell and Loch-Caruso, 1999). The inhibitory action of lindane was in contrast to stimulation of uterine contraction frequency that we observed with DDT (Juberg and Loch-Caruso, 1991;Juberg et al, , 1995 and polychlorinated biphenyl isomers (Tsai et al, 1996;Bae et al, 1999a Bae et al, ,b, 2001, which were also elevated in the blood of women who experienced premature delivery or spontaneous abortion (Saxena et al, 1981;Wassermann et al, 1982). We subsequently used lindane as an inhibitor for probing physiologic and pathologic mechanisms of regulation of uterine contraction, and identified a previously unrecognized role for reactive oxygen species (Krieger and Loch-Caruso, 2001) and a previously unidentified myometrial phospholipase A 2 activity (Wang et al, 2001).…”

Section: Introductionmentioning

confidence: 63%

“…In women admitted to a hospital in India for obstetrical care who subsequently experienced preterm birth or spontaneous abortion, blood levels of lindane averaged 39.7 ppb (15-79 ppb range, n = 15) and 73.3 ppb (40-136 ppb range, n = 10), respectively (Saxena et al, , 1981. In another study of 17 Israeli women, significantly elevated concentrations of lindane (15 ppb) were detected in serum lipids of women who delivered prematurely compared with women who delivered at term (4.3 ppb) (Wassermann et al, 1982). A limitation of both human studies is that other organochlorine substances were also significantly elevated in the blood of women who experienced preterm birth or spontaneous abortion, including DDT and polychlorinated biphenyl isomers that stimulate uterine contraction in rat uterine strips in vitro Juberg et al, , 1995Tsai et al, 1996;Bae et al, 1999a Bae et al, ,b, 2001.…”

mentioning

confidence: 94%

“…The present study utilizes lindane, the γ-isomer of hexachlorocyclohexane, to investigate mechanisms of inhibition of spontaneous uterine contractions. Our laboratory initially investigated lindane's actions on uterine contraction because it was one of several organochlorine substances found in significantly elevated concentrations (15-136 ppb) in the blood lipids of women who had experienced spontaneous abortions or premature delivery compared with women who had undergone full-term pregnancy (7-39 ppb) (Saxena et al, 1981;Wassermann et al, 1982). However, in vitro exposure of rat uterine strips isolated from pregnant (Gestation Day 10) rats to cumulative concentrations of lindane at 10-min intervals was found to depress spontaneous contractions at 10 μM lindane and abolish contractions at 30 μM lindane (Criswell and Loch-Caruso, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Phospholipase-Mediated Inhibition of Spontaneous Oscillatory Uterine Contractions by Lindane in Vitro,

Wang

Loch‐Caruso

2002

Toxicology and Applied Pharmacology

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Although regulation of uterine contractility is fundamental for parturition, mechanisms by which toxicants modify uterine muscle contractions remain poorly understood. In a previous cumulative concentration-response study, 10 μM lindane (γ-hexachlorocyclohexane) reduced contraction force and 30 μM lindane abolished contractions in Gestation Day 10 rat uterine strips when lindane was added to muscle baths at 10-min intervals. Other studies showed that brief (<10 min) exposures to 10-100 μM lindane inhibit gap junctions and activate phospholipase pathways in rat myometrial cells in culture. Consequently, lindane was used as a prototype toxicant with known uterine activity to investigate the hypothesis that activation of a specific phospholipase pathway provides a mechanistic link between inhibition of uterine contraction and inhibition of myometrial gap junctions. Uterine tissue and cells were pretreated with phospholipase pathway inhibitors to evaluate the role of phospholipase pathways in lindane's actions in the uterus. Concentrations of inhibitors were selected based on previous reports of effective concentrations for the enzyme activity and on pilot toxicity studies of the inhibitors on uterine contraction and gap junction communication. To monitor uterine contractions, longitudinal uterine strips were excised from Gestation Day 10 rats and suspended in isometric muscle baths, consistent with previous experiments. Exposure in vitro for 60 min to 10-50 μM lindane, an effective concentration range for the uterine responses of interest, revealed that 30 μM lindane rapidly abolished contractions. Subsequently, uterine strips were pretreated with phospholipase pathway inhibitors and then challenged with 30 μM lindane, the lindane concentration that elicited maximal inhibition of uterine contraction. Pretreatment with 20-50 μM of the phosphatidylinositol-specific phospholipase C inhibitor 1-O-octadecyl-2-O-methyl-sn -glycerol-3-phosphorylcholine (ET-18-OCH 3 ) reversed lindane-induced inhibition of spontaneous uterine contractions. Gap junction intercellular communication was monitored by injecting the fluorescent dye Lucifer yellow into rat myometrial cells grown in culture and assessing dye transfer to adjacent cells using epifluorescence microscopy. Similar to uterine contraction, pretreatment of cell cultures with phospholipase C inhibitors (30 μM ET-18-OCH 3 , 50 μM tricyclodecan-p-yl-xanthogenate · K [D609] or 50 μM tricyclodecan-p-yl-xanthogenate · K or 2-nitro-4-carboxyphenyl-N,Ndophenylcarbamate [NCDC]) partially reversed inhibition of dye transfer by 100 μM lindane, a 4To whom correspondence and reprint requests should be addressed at 1420 Washington Heights, Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029. Fax: (734) lindane concentration previously shown to abolish myometrial Lucifer yellow dye transfer under similar culture conditions. In contrast, pretreatment with 20 μM of bromoenol lactone (BEL) to inhibit the calcium-i...

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Section: Introductionmentioning

confidence: 63%

mentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Phospholipase-Mediated Inhibition of Spontaneous Oscillatory Uterine Contractions by Lindane in Vitro,

Wang

Loch‐Caruso

2002

Toxicology and Applied Pharmacology

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“…Merecem destaque o aumento da indução de enzimas microssômicas do fígado 21 ; maior incidência de toxemia gravídica 64 ; de prematuridade 65 ; presença de lesões acneiformes 56 ; lesões difusas da pele 46 ; aumento da incidência de melanoma e de câncer do pâncreas 51 ; maior incidência de cirrose hepática e de câncer do fígado 51 ; alteração das provas de função hepá-tica 10 ; alterações congênitas de crianças cujas mães tinham ingerido alimento com teores de resíduos de PCBs, constantes de conjuntivite, prurido cutâneo, maior incidência de cárie dentária, fragilidade ungueal, pigmentação marrom da pele, esmalte dentário manchado 72 , prematuridade e menor peso ao nascer 60 , grau moderado de retardo mental 24 e depressão do sistema imunológico 53 .…”

Section: Introductionunclassified

Acúmulo de policloretos de bifenila na população do Grande São Paulo, Brasil

et al. 1987

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“…Currently, DDT use is banned in developed countries due to its effects on wildlife and suspected effects on humans. Organochlorine pesticides have been shown to affect the central nervous system (1); other chronic effects recently reported include an increased risk of breast cancer (2)(3)(4)(5), leukemias (6,7), pancreatic cancer (8,9), and reproductive outcomes (10)(11)(12)(13).…”

mentioning

confidence: 99%

Exposure Assessment for Workers Applying DDT to Control Malaria in Veracruz, Mexico

Rivero-Rodriguez¹,

Borja-Aburto²,

Santos‐Burgoa³

et al. 1997

Environmental Health Perspectives

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Premature delivery and organochlorine compounds: Polychlorinated biphenyls and some organochlorine insecticides

Cited by 88 publications

References 6 publications

Phospholipase-Mediated Inhibition of Spontaneous Oscillatory Uterine Contractions by Lindane in Vitro,

Phospholipase-Mediated Inhibition of Spontaneous Oscillatory Uterine Contractions by Lindane in Vitro,

Acúmulo de policloretos de bifenila na população do Grande São Paulo, Brasil

Exposure Assessment for Workers Applying DDT to Control Malaria in Veracruz, Mexico

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