Premature Death Among Outpatients at a Community Mental Health Center

Corten, Philippe; Ribourdouille, Michèle; Dramaix, M.

doi:10.1176/ps.42.12.1248

Cited by 17 publications

(11 citation statements)

References 8 publications

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“…Our finding of excess mortality across all age groups of psychiatric patients has been well described [34–37]. However, the decline in the aRR of all-cause and cardiac mortality with increasing age is surprising.…”

Section: Discussionsupporting

confidence: 71%

Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users: A Study with the General Practice Research Database

Murray‐Thomas

Jones

Patel

et al. 2013

Cardiovascular Psychiatry and Neurology

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Objective. Antipsychotics have been associated with increased cardiac events including mortality. This study assessed cardiac events including mortality among antipsychotic users relative to nonusers. Methods. The General Practice Research Database (GPRD) was used to identify antipsychotic users, matched general population controls, and psychiatric diseased nonusers. Outcomes included cardiac mortality, sudden cardiac death (SCD), all-cause mortality (excluding suicide), coronary heart disease (CHD), and ventricular arrhythmias (VA). Sensitivity analyses were conducted for age, dose, duration, antipsychotic type, and psychiatric disease. Results. 183,392 antipsychotic users (115,491 typical and 67,901 atypical), 544,726 general population controls, and 193,920 psychiatric nonusers were identified. Nonusers with schizophrenia, dementia, or bipolar disorder had increased risks of all-cause mortality compared to general population controls, while nonusers with major depression had comparable risks. Relative to psychiatric nonusers, the adjusted relative ratios (aRR) of all-cause mortality in antipsychotic users was 1.75 (95% CI: 1.64–1.87); cardiac mortality 1.72 (95% CI: 1.42–2.07); SCD primary definition 5.76 (95% CI: 2.90–11.45); SCD secondary definition 2.15 (95% CI: 1.64–2.81); CHD 1.16 (95% CI: 0.94–1.44); and VA 1.16 (95% CI: 1.02–1.31). aRRs of the various outcomes were lower for atypical versus typical antipsychotics (all-cause mortality 0.83 (95% CI: 0.80–0.85); cardiac mortality 0.89 (95% CI: 0.82–0.97); and SCD secondary definition 0.76 (95% CI: 0.55–1.04). Conclusions. Antipsychotic users had an increased risk of cardiac mortality, all-cause mortality, and SCD compared to a psychiatric nonuser cohort.

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Section: Discussionsupporting

confidence: 71%

Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users: A Study with the General Practice Research Database

Murray‐Thomas

Jones

Patel

et al. 2013

Cardiovascular Psychiatry and Neurology

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“…In our study excess mortality was found across all age groups but was especially high among both men and women younger than 45 years, which is a common finding (9,15,(48)(49)(50). Hannerz and Borgå (51) suggested that among younger persons with psychiatric illness, excess mortality is mainly due to suicide and accidents, which may be related to the high level of vulnerability of the early phase of illness, when insight, treatment adherence, and coping skills may be poor.…”

Section: Agesupporting

confidence: 56%

“…In a study conducted in Norway after 1980, when the bed-to-population ratio was reduced by 50 T Ta ab bl le e 5 5 Poisson multivariate analysis on standardized mortality ratios examining natural and unnatural deaths among psychiatric patients discharged from hospitals in 1987 in the province of Florence, Italy sen and associates (9) found an SMR of 3.2 for men and 2.4 for women in a 12-year follow up of 1,055 patients admitted to a public psychiatric hospital from a defined catchment area. In a study conducted in Norway after 1980, when the bed-to-population ratio was reduced by 50 T Ta ab bl le e 5 5 Poisson multivariate analysis on standardized mortality ratios examining natural and unnatural deaths among psychiatric patients discharged from hospitals in 1987 in the province of Florence, Italy sen and associates (9) found an SMR of 3.2 for men and 2.4 for women in a 12-year follow up of 1,055 patients admitted to a public psychiatric hospital from a defined catchment area.…”

Section: Other Studiesmentioning

confidence: 99%

Mortality Among Discharged Psychiatric Patients in Florence, Italy

Meloni¹,

Miccinesi²,

Bencini³

et al. 2006

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“…57 No. 11 1 16 60 07 7 P opulation research has consistently shown increased mortality and morbidity among persons with severe mental illness (1)(2)(3)(4)(5)(6)(7)(8). Reduced risks of negative outcomes have been associated with increased supervision or oversight (9)(10)(11).…”

mentioning

confidence: 99%

Effect of Conditional Release From Hospitalization on Mortality Risk

Segal¹,

Burgess²

2006

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Premature Death Among Outpatients at a Community Mental Health Center

Cited by 17 publications

References 8 publications

Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users: A Study with the General Practice Research Database

Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users: A Study with the General Practice Research Database

Mortality Among Discharged Psychiatric Patients in Florence, Italy

Effect of Conditional Release From Hospitalization on Mortality Risk

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