Premaquick<sup>©</sup> versus modified Bishop score for preinduction cervical assessment at term: A double‐blind randomized trial

Eleje, George Uchenna; Ezugwu, Euzebus Chinonye; Ugwu, Emmanuel Onyebuchi; Ezebialu, Ifeanyichukwu U.; Eleje, Lydia İjeoma; Ojiegbe, Nnabuike O.; Ajah, Leonard Ogbonna; Obiora, Chukwudi Celestine; Egeonu, Richard Obinwanne; Okafor, Chigozie Geoffrey; Enyinna, Perpetua Kelechi; Egede, John Okafor; Ugochukwu, Nzubechukwu; Asiegbu, Amarachukwu C.; Ikechebelu, Joseph Ifeanyichukwu

doi:10.1111/jog.13691

Cited by 3 publications

(16 citation statements)

References 29 publications

(51 reference statements)

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“…8 This finding is also similar to a previous randomized control trial on nulliparous women by Eleje et al, which reported a vaginal delivery success rate of 78.9% in Premaquick group. 6 The findings are interesting as a greater number of women had successful vaginal delivery following cervical ripening and induction of labour in either method. This finding further suggests that both methods of pre-induction cervical assessment are effective and safe.…”

Section: Discussionmentioning

confidence: 98%

“…The negative test was when the three T lines were absent or when there was the presence of only one T line. 6,23…”

Section: Methodsmentioning

confidence: 99%

“…Thus intravenous oxytocin (10 IU in 1000 ml of 5% dextrose in water) was administered using gravity-fed manual drip set at 10 drops per min and increased by 10 drops per min every 30 min, up to a maximum of 60 dpm or adequate uterine contractions were obtained. 6,27,28 Amniotomy was done when the presenting part was at station 0, dilated at least 4 cm and the fetal head was well applied to the cervix.…”

Section: Methodsmentioning

confidence: 99%

“…5 This has led to development of other newer and more modalities or methods like transvaginal ultrasound (TVUS) measurement of cervical length and checking for the presence of phosphorylated forms of insulin-like growth factor-binding protein-1 (IGFBP-1), fetal fibronectin, interleukin-6 (IL-6) or their combination in cervico-vaginal fluid at term. 6…”

Section: Introductionmentioning

confidence: 99%

“…20,21 Premaquick in a randomized study has demonstrated to be superior to Bishop score for pre-induction cervical evaluation. 6 Since newer studies have demonstrated the superiority of either TVUS measurement of cervical length or Premaquick over Bishop score, which is an age-old method of pre-induction cervical assessment, it will be necessary to compare these two superior methods in a randomized clinical trial.…”

Section: Introductionmentioning

confidence: 99%

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A randomized clinical trial of Premaquick biomarkers versus transvaginal cervical length for pre-induction cervical assessment at term among pregnant women

et al. 2023

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Objectives: To compare Premaquick biomarkers (combined insulin-like growth-factor binding protein 1 and interleukin-6) and cervical length measurement via transvaginal ultrasound for pre-induction cervical evaluation at term among pregnant women. Methods: A randomized clinical trial of consenting pregnant women at the Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria. The women were randomized equally into Premaquick group ( n = 36) and transvaginal ultrasound group ( n = 36). The cervix was adjudged ‘ripe’ if the Premaquick test was positive or if the trans-vaginal measured cervical length was less than 28 mm. The primary outcome measures were the proportions of women who needed prostaglandin analogue for cervical ripening and the proportion that achieved vaginal delivery after induction of labour. The trial was registered in Pan African clinical trial registry (PACTR) registry with approval number PACTR202001579275333. Results: The baseline characteristics were similar between the two groups ( p > 0.05). There was no statistically significant difference between the two groups in terms of proportion of women that required prostaglandins for pre-induction cervical ripening (41.7 versus 47.2%, p = 0.427), vaginal delivery (77.8 versus 80.6%, p = 0.783), mean induction to delivery interval (22.9 ± 2.81 h versus 24.04 ± 3.20 h, p = 0.211), caesarean delivery (22.2 versus 19.4%, p = 0.783), proportion of neonate with birth asphyxia (8.30 versus 8.30%, p = 1.00) and proportion of neonate admitted into special care baby unit (16.7 versus 13.9%, p = 0.872). Subgroup analysis of participants with ‘ripe’ cervix at initial pre-induction assessment showed that the mean induction to active phase of labour interval and mean induction to delivery interval were significantly shorter in Premaquick than transvaginal ultrasound group. Conclusion: Pre-induction cervical assessment at term with either Premaquick biomarkers or transvaginal ultrasound for cervical length is effective, objective and safe with similar and comparable outcome. However, when compared with women with positive transvaginal ultrasound at initial assessment, women with positive Premaquick test at initial assessment showed a significantly shorter duration of onset of active phase of labour and delivery of baby following induction of labour.

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Section: Discussionmentioning

confidence: 98%

“…The negative test was when the three T lines were absent or when there was the presence of only one T line. 6,23…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A randomized clinical trial of Premaquick biomarkers versus transvaginal cervical length for pre-induction cervical assessment at term among pregnant women

et al. 2023

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Safety and efficacy of titrated oral misoprostol solution versus vaginal dinoprostone for induction of labor: A single‐center randomized control trial

Xiu

Zhang

Xia

et al. 2021

Intl J Gynecology & Obste

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Neutrophil Elastase as a Predictor of Delivery in Pregnant Women with Preterm Labour

Eleje,

Nwagha,

Ezebialu

et al. 2023

Explor Res Hypothesis Med

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Background and objectives: No previous study has been conducted in Nigeria on the role of neutrophil elastase in predicting preterm birth. The present study aimed to determine the role of the neutrophil elastase test in predicting birth in women with preterm labor. Methods: The present prospective cohort study recruited 83 pregnant women with preterm labor between 28 and 36 +6 weeks of gestation, and followed up these subjects for 14 days. The controls comprised 85 pregnant women without preterm labor. The cervicovaginal fluid was collected and tested using the neutrophil elastase test. Then, the sensitivity, specificity, and positive and negative predictive parameters were determined. Afterward, the data were scrutinized using the SPSS arithmetic software (Sort23). Results: Among the 168 pregnant women analyzed in the present study, 83 pregnant women were assigned to the preterm labor group, and 85 pregnant women were assigned to the control group. Furthermore, among the 83 pregnant women in the preterm labor group, 11 women had spontaneous preterm delivery, leading to a spontaneous preterm birth proportion of 13.3%. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the neutrophil elastase test within 14 days post-enrollment were 93.8%, 61.2%, 36.6%, 97.6%, and 67.5%, respectively, for the general population, and 87.5%, 66.7%, 35.0%, 96.3%, and 70.2%, respectively, for subjects at <35 weeks of gestation. The positive and negative likelihood ratios for preterm birth prediction were 2.62 and 0.19, respectively. Conclusion: The neutrophil elastase test exhibited high predictive accuracy in pregnant women with preterm labor, when compared to the controls, based on the sensitivity and negative predictive value, but this had poor positive predictive values. The neutrophil elastase test may be used as a screening test, but not as a potential predictive test, in the routine clinical setting.

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Premaquick^© versus modified Bishop score for preinduction cervical assessment at term: A double‐blind randomized trial

Cited by 3 publications

References 29 publications

A randomized clinical trial of Premaquick biomarkers versus transvaginal cervical length for pre-induction cervical assessment at term among pregnant women

A randomized clinical trial of Premaquick biomarkers versus transvaginal cervical length for pre-induction cervical assessment at term among pregnant women

Safety and efficacy of titrated oral misoprostol solution versus vaginal dinoprostone for induction of labor: A single‐center randomized control trial

Neutrophil Elastase as a Predictor of Delivery in Pregnant Women with Preterm Labour

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Premaquick© versus modified Bishop score for preinduction cervical assessment at term: A double‐blind randomized trial

Cited by 3 publications

References 29 publications

A randomized clinical trial of Premaquick biomarkers versus transvaginal cervical length for pre-induction cervical assessment at term among pregnant women

A randomized clinical trial of Premaquick biomarkers versus transvaginal cervical length for pre-induction cervical assessment at term among pregnant women

Safety and efficacy of titrated oral misoprostol solution versus vaginal dinoprostone for induction of labor: A single‐center randomized control trial

Neutrophil Elastase as a Predictor of Delivery in Pregnant Women with Preterm Labour

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Premaquick^© versus modified Bishop score for preinduction cervical assessment at term: A double‐blind randomized trial