Premalignant lesions of the oral cavity: current perspectives

Swain, Santosh Kumar

doi:10.18203/2320-6012.ijrms20212259

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…Injury to the sublingual salivary gland duct leads to mucus extravasation into the submucosa via hydrostatic pressure and the development of pseudocyst from mucus escape reaction. 17 Direct trauma can damage the acini with consequent ductal blockage, and backpressure secretion builds up with subsequent acini rupture. Subsequently, there is raised hydrostatic pressure, extravasation of mucus, and then the formation of the pseudocyst.…”

Section: Etiopathologymentioning

confidence: 99%

“…28 Imaging is advised mainly to know the extension of swelling before surgery or when the diagnosis is unclear. 29 Ultrasound is recommended for ranula as a preferred diagnostic tool. Ultrasound provides additional information about the relationship between the pseudocyst on the floor of the oral cavity and the sublingual gland and mylohyoid muscle.…”

Section: Diagnosismentioning

confidence: 99%

“…Ultrasound is an inexpensive and repeatable examination method that is helpful during follow-up. 29 Ultrasound is a safe and reliable method in ranula, especially in patients with plunging ranula, and can help with differential diagnoses like other types of cystic lesions and benign tumors and with monitoring the patients during follow-up. 30 Highresolution ultrasound determines the extent of the plunging ranula and confirms the cystic nature of the lesion and assesses the status of the mylohyoid muscle and evaluates the sublingual gland for rupture or herniation.…”

Section: Diagnosismentioning

confidence: 99%

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Ranula: a narrative review

Swain

Dubey

2022

Int J Res Med Sci

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A ranula is a pseudocystic lesion of the sublingual salivary gland, found in the floor of the mouth. Ranula is classified into types such as simple and plunging type. Plunging ranula arises when a simple ranula extends beyond the floor of the mouth into the neck. A simple ranula is seen above the level of the mylohyoid muscle and is often the result of sublingual gland duct obstruction. A plunging ranula refers to a pseudocyst that develops with salivary duct rupture and is seen below the level of the mylohyoid muscle. Diagnosis of the ranula is difficult even with modern imaging techniques as this mimic to other neck lesions. The correct diagnosis of the ranula is essential for the most effective treatment. The treatment modalities of the ranula currently include marsupialization, excision of the ranula with or without excision of the sublingual gland, cryosurgery, laser excision, sclerotherapy, fenestrations, and continuous pressure. The treatment of the ranula includes complete excision and marsupialization is not a sufficient treatment. Misdiagnosis of a plunging ranula leads to unnecessary and extensive surgery. This review article discussed the epidemiology, etiopathogenesis, clinical features, diagnosis, and current treatment of ranula.

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Section: Etiopathologymentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

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Ranula: a narrative review

Swain

Dubey

2022

Int J Res Med Sci

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“…All oral mucosa lesions with the risk of malignant changes are included under the term OPMD. 1 Its exact etiology is unknown, but there is strong evidence confirming the role of lymphocytes in the pathogenesis of this disorder. 2 Immune system deficiency plays a primary role in the development of this disease, and it is currently considered a disorder mediated by autoimmune cells.…”

Section: Introductionmentioning

confidence: 99%

“…The common term (OPMD) of potentially malignant oral disorders is suggested for oral premalignancy, including premalignant lesions (oral leukoplakia, erythroplakia, and proliferative verrucous leukoplakia) and premalignant conditions (lichen planus and submucosal fibrosis). All oral mucosa lesions with the risk of malignant changes are included under the term OPMD 1 . Its exact etiology is unknown, but there is strong evidence confirming the role of lymphocytes in the pathogenesis of this disorder 2 .…”

Section: Introductionmentioning

confidence: 99%

The correlation between human papillomavirus and oral lichen planus: A systematic review of the literature

Agha‐Hosseini

Motlagh

2023

Immunity Inflam & Disease

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IntroductionOral lichen planus (OLP) is a chronic inflammatory disorder with cell‐induced immunopathological responses and is considered a potential malignancy disorder in the oral cavity. Due to the high prevalence of OLP as well as the potential for malignancy, human papillomaviruses (HPVs) may play an important role in it. Although previous studies have explored the possible relationship between HPV and OLP, the findings have been conflicting and nonconclusive. This study aims to review the studies that investigated HPV‐16 and HPV‐18 in OLP.Methods and MaterialsThe research protocol followed the Preferred Reporting Items for Systematic Reviews (PRISMA2020) checklist. The online databases Pubmed, Scopus, Embase, Google Scholar, and Cochrane were searched using the following individual keywords: “OLP” OR “Oral Lichen Planus” OR “HPV” OR “Human Papillomavirus.” The search strategy resulted in the selection of 80 articles. The articles were evaluated, and after duplication removal, 53 abstracts were reviewed, resulting in the selection of 25 studies according to inclusion and exclusion criteria. The risk of bias assessment was done by using the Modified Newcastle–Ottawa quality assessment scale. The overall prevalence of HPV in OLP lesions varied from 2.7% to 70%, depending on the type of diagnostic method used.ConclusionDespite the studies conducted on the relationship between OLP and HPV infection, there is still no conclusive evidence that HPV can play a role in the etiopathogenesis of OLP, either in clinical manifestations or in the malignant transformation of lesions.

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Human papillomavirus and its association with oral lichen planus

Starshinina,

Perlamutrov,

Olhovskaya

2023

Russian Journal of Skin and Venereal Diseases

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BACKGROUND: Oral lichen planus is a chronic disease with periods of exacerbations and remissions, requiring long-term symptomatic treatment and observation. Dermatosis can occur or worsen in the presence of different triggers, for example, due to the persistence of the human papillomavirus. AIM: to explore the effect human papillomavirus on the characteristics oral lichen planus. MATERIALS AND METHODS: 90 patients with oral lichen planus aged from 26 to 73 years (average age 55.61±1.00 years) were examined. Real-time polymerase chain reaction was used to detect human papillomavirus. The need for treatment of caries, Green–Vermillion and complex periodontal indices were used to analysis state of oral hygiene. RESULTS: Human papillomavirus DNA was detected in 53 (58.88%) cases. Patients of this group were 4 years younger than other study participants; the duration of dermatosis is 2 years longer with a predominance of atrophic/erythematous and erosive/ulcerative forms. It was noted that indexes of caries and the complex periodontal were significantly (p=0,007 and p=0,030 respectively) higher compared to patients without papillomavirus infection. CONCLUSION: It is found features of oral lichen planus in identifying human papillomavirus: early onset; severe of the disease with predominantly destructive forms; high prevalence of caries and periodontitis.

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Premalignant lesions of the oral cavity: current perspectives

Cited by 6 publications

References 24 publications

Ranula: a narrative review

Ranula: a narrative review

The correlation between human papillomavirus and oral lichen planus: A systematic review of the literature

Human papillomavirus and its association with oral lichen planus

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