PRELP secreted from mural cells protects the function of blood brain barrier through regulation of endothelial cell-cell integrity
Hongorzul Davaapil,
Jack Hopkins,
Nadia Bonnin
et al.
Abstract:Introduction: Proline/arginine-rich end leucine-rich repeat protein (PRELP), is a small secreted proteoglycan expressed by pericytes and vascular smooth muscle cells surrounding the brain vasculature of adult mouse.Methods: We utilised a Prelp knockout (Prelp−/−) mouse model to interrogate vasculature integrity in the brain alongside performing in vitro assays to characterise PRELP application to endothelial cells lines. Our findings were supplemented with RNA expression profiling to elucidate the mechanism of… Show more
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