Preliminary ultrasonographical observations of intestinal lesions in a community with heavy Schistosoma mansoni infection in Richard Toll, Senegal

Dittrich, Matthias; Thomas, Anna; Stelma, F.F.; Talla, I.; Niang, M.; Decam, Ch.; Sow, S.; Mbaye, Amadou; Gryseels, B.; Ehrich, J. H. H.; Doehring, E

doi:10.1016/0001-706x(94)90026-4

Cited by 6 publications

(4 citation statements)

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“…It can activate the PI3K/Akt signal transduction pathway and other oncogenic signaling pathways [ 21 ]. For example, it has been confirmed that in the early stage of cancer, the increase of nerve density is parallel to the increase of neurotrophin level, but it remains to be clarified which cells in TME are the source of neurotrophin and the nature of the stimulants that initiate the production of neurotrophin [ 22 ]. Besides, a previous study reported that Neurotrophin Receptor TrkB (NTRK2) and Wnt β-Estradiol and MAPK signaling pathways are closely related to the worse prognosis of neuroblastoma [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

miRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer

Gao

Guo

et al. 2022

Aging

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Background: FAM83D (family with sequence similarity 83, member D) is of particular interest in tumorigenesis and tumor progression. Ovarian cancer is the leading cause of cancer-related death in women all over the world. This study aims to research the association between FAM83D and ovarian cancer (OC). Methods: The gene expression data of OC and normal samples (GSE81873 and GSE27651) was downloaded from Gene Expression Omnibus (GEO) dataset. The bioinformatics analysis was performed to distinguish two differentially expressed genes (DEGs), prognostic candidate genes and functional enrichment pathways. Immunohistochemistry (IHC), Quantitative Real-time PCR (qPCR), and luciferase reporter assays were utilized for further study. Results: There were 56 DEMs and 63 DEGs in cancer tissues compared to normal tissues. According to the km-plot software, hsa-miR-142-3p and FAM83D were associated with the overall survival of patients with OC. Besides, Multivariate analysis included that hsa-miR-142-3p and FAM83D were independent risk factors for OC patients. Furthermore, qPCR demonstrated that miRNA-142-3p and FAM83D were differentially expressed in normal ovarian tissues (NOTs) and ovarian cancer tissues (OCTs). IHC results indicated that FAM83D was overexpressed in OCTs compared with NOTs. Last but not least, luciferase reporter assays verified that FAM83D was a direct target of hsa-miRNA-142-3p in OC cells. Conclusions: The prognostic model based on the miRNA-mRNA network could provide predictive significance for the prognosis of OC patients, which would be worthy of clinical application. Our results concluded that miR-142-3p and its targets gene FAM83D may be potential diagnostic and prognostic biomarkers for patients with OC.

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Section: Discussionmentioning

confidence: 99%

miRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer

Gao

Guo

et al. 2022

Aging

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“…The decrease of E-cadherin expression level is significantly related to the malignancy of tumor cells. The expression level of E-cadherin in breast cancer cells with low malignancy was significantly higher than that in malignant tumor cells, and its expression level was directly proportional to the formation of glandular canaliculi [ 20 – 22 ]. In vitro experiments more clearly confirmed the relationship between E-cadherin molecule and tumor invasion ability.…”

Section: Discussionmentioning

confidence: 99%

Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 and Its Related Molecules as Potential Biomarkers in Small-Cell Lung Cancer

Zhu

Gao

et al. 2022

BioMed Research International

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Background. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) plays a key role in tumorigenesis and tumor progression. Lung cancer is the leading cause of cancer-related death in men and women all over the world. However, the relationship between IGF2BP3 and small-cell lung cancer (SCLC) has not been reported yet. Methods. SCLC and normal samples (GSE19945 and GSE149507) were obtained in the Gene Expression Omnibus (GEO) dataset. Differential genes were screened by R software, and functional analysis and signal pathway enrichment analysis were carried out. In addition, we used the survival analysis database to analyze the relationship between prognosis and gene expression. Besides, immunohistochemistry (IHC) and quantitative real-time PCR (qPCR) were used for further research. Results. Five differentially expressed miRNAs and 9 differentially expressed mRNAs were selected by using R software. Survival analysis database results show that C7, CLIC5, PRDX1, IGF2BP3, and LDB2 were related the overall survival of patients with SCLC. Furthermore, multivariate analysis included that IGF2BP3 was independent risk factors for SCLC patients. Besides, gene function and signal pathway enrichment analysis showed that differentially expressed miRNAs were involved in the process of tumorigenesis and development. Furthermore, IHC and qPCR outcomes showed that the expression level of hsa-miR-182, hsa-miR-183, and IGF2BP3 was differentially expressed in normal lung tissues (NLTs) and SCLC tissues (SCLCTs). Conclusions. Our results concluded that hsa-miR-182, hsa-miR-183, and IGF2BP3 may take part in the development of SCLC.

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“…US reports on intestinal schistosomiasis, however, are extremely scant. Dittrich and colleagues [13] performed intestinal US on 173 individuals in an endemic area of Senegal, reporting intestinal abnormalities in 82% of patients with documented (Kato-Katz positive) S . mansoni infection and 60% of uninfected patients, with an apparent positive correlation between infection intensity (eggs per gram of faeces) and prevalence of abnormalities on US.…”

Section: Discussionmentioning

confidence: 99%

“…A standardized protocol for the evaluation and grading of hepatosplenic schistosomiasis using US was issued by the WHO in 2000 [12] and recently evaluated for usability and usefulness [6]. On the contrary, reports on the use of US in the evaluation of intestinal schistosomiasis are extremely scant [11, 13], and there is no US report on the evolution of the lesions, when visualized, after treatment, either in endemic areas or in case of no risk of reinfection.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound and intestinal lesions in Schistosoma mansoni infection: A case-control pilot study outside endemic areas

et al. 2018

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BackgroundInfection with Schistosoma mansoni is a major cause of morbidity and mortality in endemic areas, and is increasingly diagnosed in migrants and travellers outside transmission areas. Markers for the assessment of morbidity and impact of control programs in endemic areas and for the clinical management of patients in the clinical setting are scant, especially for intestinal involvement. Ultrasonography is well established to evaluate hepatosplenic pathology; on the contrary, ultrasound evaluation of intestinal schistosomiasis is virtually unexplored. In this pilot study, we aimed to describe and evaluate the accuracy of unenhanced intestinal ultrasound for morbidity due to intestinal S. mansoni infection.Methodology/Principal findingsWe performed a blind case-control study of unenhanced intestinal ultrasound on 107 adults accessing the outpatient clinic of our Centre for Tropical Diseases between January-July 2018 as part of a screening for tropical diseases in migrants and travellers returning from endemic areas. Other clinical and laboratory data were obtained routine examination reports. We could not find any overtly pathological thickness of the gut wall in the sigma, proximal ascending colon, and terminal ileum, in patients with S. mansoni infection (n = 17), S. haematobium infection (n = 7), positive anti-Schistosoma serology (n = 31), and uninfected individuals (n = 52), with no difference among groups as assessed by ANOVA. No polyps or other intestinal abnormalities were visualized. There was no significant change in gut wall thickness one month after treatment with praziquantel in patients with S. mansoni infection (n = 11).Conclusions/SignificanceOur preliminary results suggest that intestinal ultrasound might not be a sensitive tool for detecting minor intestinal morbidity due to schistosomiasis. Further studies in a hospital setting comparing colonoscopy and ultrasonography may be envisaged; in endemic areas, further studies are needed to describe and assess the usefulness of intestinal ultrasound in patients stratified by infection intensity and compared with markers such as calprotectin and fecal occult blood.

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Preliminary ultrasonographical observations of intestinal lesions in a community with heavy Schistosoma mansoni infection in Richard Toll, Senegal

Cited by 6 publications

References 10 publications

miRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer

miRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer

Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 and Its Related Molecules as Potential Biomarkers in Small-Cell Lung Cancer

Ultrasound and intestinal lesions in Schistosoma mansoni infection: A case-control pilot study outside endemic areas

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