Preliminary toxicity and phytochemical studies of the stem bark aqueous extract of Musanga cecropioides in rats

Adeneye, Adejuwon Adewale; Ajagbonna, O. P.; Adeleke, Tajudeen I.; Bello, Shaibu Oricha

doi:10.1016/j.jep.2005.11.027

Cited by 209 publications

(152 citation statements)

References 14 publications

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“…Finding from the study revealed that both doses of the ethanol and aqueous extracts of P. mildbraedii leaves did not have adverse effects on the hematology parameters considered in this study but boost the blood levels of some parameters. The hematopoietic system is very sensitive to toxic compounds and serves as an important index of the physiological and pathological status in both animals and humans (Kulkarni and Veeranjaneyulu, 2012;Adeneye et al, 2006). There was a significant (p< 0.05) increase in almost all the hematological parameters considered in this study when comparing the results obtained from rats in control group with the extracts treated rats.…”

Section: Discussionmentioning

confidence: 59%

Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on hematology parameters and cholesterol in albino rats

Victor¹,

Nonyelum²

2017

Afr. J. Biochem. Res.

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One of the commonly consumed leafy vegetables in Nigeria is, on two groups of rats for 28 days showed no adverse effects on the hematological parameters considered in this study. There was a significant (p < 0.05) dose dependent increase in almost all the hematological parameters. However, the serum cholesterol level was significantly reduced in rats exposed to both doses of the ethanol and aqueous extracts of the plant leaf as compared to the rats in the control group. These effects of the extracts increased with increased doses. These results suggest non-toxic effects of the leaf extracts of P. mildbraedii on the hematological parameters, as well as an ability to help in preventing cardiovascular diseases in the diabetics.

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Section: Discussionmentioning

confidence: 59%

Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on hematology parameters and cholesterol in albino rats

Victor¹,

Nonyelum²

2017

Afr. J. Biochem. Res.

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“…The haematopoietic system is one of the most sensitive targets of toxic compounds and is an important index of physiological and pathological status in man and animals [14]. In addition, most of the biochemical parameters were not also altered by the extract.…”

Section: Discussionmentioning

confidence: 99%

Acute and Sub-chronic (28-day) Oral Toxicity Studies of Hydroalcohol Leaf Extract of <i>Ageratum conyzoides</i> L (Asteraceae)

Diallo¹,

Eklu-Gadegkeku²,

Agbonon³

et al. 2010

Trop. J. Pharm Res

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“…The haematopoietic system tends to be quite sensitive to toxic compounds. It acts as an important index of physiological and pathological status in both animals and humans (Adeneye et al, 2006). After 14 and 28 days of treatment with ethanolic extracts of M. malabathricum, no changes were found in the haematological parameters of either the control or treatment groups.…”

Section: Discussionmentioning

confidence: 97%

Investigation and evaluation of acute and sub-acute dermal toxicity studies of ethanolic leaves extract of Melastoma malabathricum in Sprague Dawley rats

Zahi¹,

Hamzah²,

Shaari³

et al. 2017

Int. J. Curr. Res. Med. Sci.

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Melastoma malabathricum is an important plant commonly used in traditional medicine. Until recently, the dermal toxicity profile of M. malabathricum remained unknown. The objective of this study is to investigate the in vivo acute and sub-acute dermal toxicity of ethanolic leaves extract of M. malabathricum in rats. In acute experiment, a total of 20 female rats were divided into four groups, each group had five rats. While, a total of 30 male rats were divided into five groups, each group consisted of six rats in sub-acute experiment. Single doses of the extract at 2000 and 5000 mg/kg of body weight failed to produce treatment-related signs of toxicity or mortality during the 14-day observation period. In a repeated dose 28-day study, 500, 1000 and 2000 mg/kg of body weight/day applications of leaf extract lead to no significant change (p >0.05) in bodyweight or haematological and biochemical parameters compared with the control group. Similarly, gross pathology and histopathology examinations of liver, spleen, kidneys, and skin did not reveal any morphological alteration. Results indicate that the close application of M. malabathricum leaves extract had no critically dangerous effect on the rats tested. Therefore, the concentrate may be used pharmaceutically.

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Preliminary toxicity and phytochemical studies of the stem bark aqueous extract of Musanga cecropioides in rats

Cited by 209 publications

References 14 publications

Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on hematology parameters and cholesterol in albino rats

Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on hematology parameters and cholesterol in albino rats

Acute and Sub-chronic (28-day) Oral Toxicity Studies of Hydroalcohol Leaf Extract of <i>Ageratum conyzoides</i> L (Asteraceae)

Investigation and evaluation of acute and sub-acute dermal toxicity studies of ethanolic leaves extract of Melastoma malabathricum in Sprague Dawley rats

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