Preliminary synchrotron analysis of lead in hair from a lead smelter worker

Martin, Ronald R.; Kempson, Ivan M.; Naftel, S. J.; Skinner, William

doi:10.1016/j.chemosphere.2004.09.087

Cited by 53 publications

(40 citation statements)

References 11 publications

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“…The levels reported in remains from the Franklin expedition are consistent with neurological effects which may have contributed to the failure of the mission [9,22,23]. However, anomalously high Pb was not uncommon in the eighteenth and nineteenth centuries [24][25][26][27]. Thus, the essential question is whether the Pb bone isotope ratios reported by Kowal et al [14] could be achieved in the space of a few years at most if the sole Pb source on the expedition was from the tins and was sufficient to swamp preexisting Pb isotope ratios.…”

supporting

confidence: 57%

“…There was extensive Pb piping aboard the ships and M'Clintock [2] reports finding Pb sheeting as part of the cargo of a boat, which was apparently being dragged overland by members of the expedition. In addition, the high levels of Pb in the hair samples reported by Kowal et al [14] would be better indicators of environmental exposure to Pb rather than ingestion [24], and may be indicative of Pb from sources other than the solder.…”

mentioning

confidence: 99%

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Pb distribution in bones from the Franklin expedition: synchrotron X-ray fluorescence and laser ablation/mass spectroscopy

et al. 2013

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Synchrotron micro-X-ray Fluorescence has been used to map the metal distribution in selected bone fragments representative of remains associated with the Franklin expedition. In addition, laser ablation mass spectroscopy using a 25 µm diameter circular spot was employed to compare the Pb isotope distributions in small regions within the bone fragments. The X-ray Fluorescence mapping shows Pb to be widely distributed in the bone while the Pb isotope ratios obtained by laser ablation within small areas representative of bone with different Pb exchange rates do not show statistically significant differences. These results are inconsistent with the hypothesis that faulty solder seals in tinned meat were the principle source of Pb in the remains of the expedition personnel.

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supporting

confidence: 57%

mentioning

confidence: 99%

Pb distribution in bones from the Franklin expedition: synchrotron X-ray fluorescence and laser ablation/mass spectroscopy

et al. 2013

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“…The SH washing procedure was carried out in order to provide an accurate assessment of endogenous metal contents. Each sample was washed with dilute Triton X-100, and then rinsed with distilled water, deionized water, and acetone [15][16][17]. The samples were dried in an oven at 80°C.…”

Section: Samples Collectionmentioning

confidence: 99%

Lead Assessment in Biological Samples of Children with Different Gastrointestinal Disorders

Shah

Ullah

Kazi

et al. 2015

Biol Trace Elem Res

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Lead (Pb) levels have been evaluated in the biological samples of children with different gastrointestinal disorders. Blood, scalp hair, and urine samples of children (of age 4-10 years) complaining about different gastrointestinal disorders were analyzed. For comparison, age matched healthy subjects were also included in this study. Biological samples were digested in a microwave oven prior to Pb determination by graphite furnace atomic absorption spectrometry. Significant differences in Pb profile were found between the diseased and referent children. Elevated Pb contents were observed in case of diseased children than WHO permissible limit, while normal results were obtained for healthy referents. The results were compared with those of healthy children having the same age, socioeconomic status, and residential areas.

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“…While 2D mapping with X-ray fl uorescence (XRF) microprobes can be used to infer internal distributions when cylindrical symmetry can be assumed, [ 15 ] hair typically needs to be sectioned [ 12 , 16 ] or tomographic measurements must be performed for information on internal distribution. [ 17 ] A fortunate property of GNPs (depending on size) is the intrinsic scattering afforded in confocal microscopy.…”

Section: Introductionmentioning

confidence: 99%

Fate of Intravenously Administered Gold Nanoparticles in Hair Follicles: Follicular Delivery, Pharmacokinetic Interpretation, and Excretion

Kempson

Chien

Chung

et al. 2012

Adv Healthcare Materials

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Gold nanoparticles (GNPs) are intravenously administered to mice. Deposition at the pilosebacious unit and whiskers is visualized with X-ray fluorescence after 30 minutes and 14 days. After 30 minutes the dermal papilla, bulge region, and root sheath all contain NPs. GNPs are driven externally out from follicles, counteractive to transfollicular delivery. After 14 days, gold bands in hairs reflect pharmacokinetic profiles indicating blood concentration kinetics. Elimination rate constants infer half-lives from 3 hairs from an individual mouse within reasonable agreement (6.08, 7.15, and 8.66 hours). 3D reconstruction of NP distributions with confocal microscopy identifies aggregates within the medullary canal. Intermittent NP deposition continues randomly over the two week period demonstrating prolonged NP mobility in vivo. NPs are still retained at the hair bulb after 14 days. The observations further account for the excretory mechanisms of NPs and their behavior in the pilosebacous unit, and demonstrate monitoring pharmacokinetic behavior in individual animals.

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Preliminary synchrotron analysis of lead in hair from a lead smelter worker

Cited by 53 publications

References 11 publications

Pb distribution in bones from the Franklin expedition: synchrotron X-ray fluorescence and laser ablation/mass spectroscopy

Pb distribution in bones from the Franklin expedition: synchrotron X-ray fluorescence and laser ablation/mass spectroscopy

Lead Assessment in Biological Samples of Children with Different Gastrointestinal Disorders

Fate of Intravenously Administered Gold Nanoparticles in Hair Follicles: Follicular Delivery, Pharmacokinetic Interpretation, and Excretion

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