Preliminary study on the anti-apoptotic mechanism of Astragaloside IV on radiation-induced brain cells

Liu, Xin; Chu, Weiwei; Shang, Shuying; Ma, Liang; Jiang, Chenxin; Ding, Yulin; Wang, Jianlin; Zhang, Shengxiang; Shao, Bin

doi:10.1177/2058738420954594

Cited by 9 publications

(5 citation statements)

References 52 publications

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“…The anti-apoptotic activity of AS-IV has been described previously. Liu et al (2020) reported that AS-IV prevented radiation-induced apoptosis in brain cells by suppressing the expression of pro-apoptotic proteins. In another study, Liu et al (2017) demonstrated that AS-IV protected against IL-1β-induced chondrocyte apoptosis by upregulating autophagy activity in chondrocytes.…”

Section: Discussionmentioning

confidence: 99%

Astragaloside IV Ameliorates Myocardial Infarction Induced Apoptosis and Restores Cardiac Function

Sun¹,

Zeng²,

Wang³

et al. 2021

Front. Cell Dev. Biol.

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BackgroundType 2 diabetes mellitus increases the risk of cardiovascular disease including myocardial infarction (MI). Inflammation and apoptosis have been implicated in the pathophysiology of MI. In the present study, the effects of astragaloside IV (AS-IV) on MI in diabetic mice were evaluated.MethodsHigh glucose/high fat (HG/HF) and hypoxia culture condition were established to mimic diabetic condition. After administration of AS-IV to H9c2 myocytes, the cell apoptosis, viability, and activation of mitogen-activated protein kinase (MAPK) signaling pathways were detected. MI was induced in streptozotocin-induced diabetic mice. After administration of AS-IV to mice, cardiac function, cardiac fibrosis, inflammation, and activation of MAPK signaling pathway were detected.ResultsAstragaloside IV treatment significantly inhibited HG/HF and hypoxia-induced apoptosis of H9c2. AS-IV inhibited activation of JNK and p38 signaling pathway while promoting the activation of EKR signaling pathway. AS-IV treatment rescued cardiac function, suppressed cardiac fibrosis and inflammation, and differently regulated the activation of MAPK signaling pathways.ConclusionAstragaloside IV prevented apoptosis and restored cardiac function in MI, which may be due to the regulation of MAPK signaling pathway in diabetes.

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Section: Discussionmentioning

confidence: 99%

Astragaloside IV Ameliorates Myocardial Infarction Induced Apoptosis and Restores Cardiac Function

Sun¹,

Zeng²,

Wang³

et al. 2021

Front. Cell Dev. Biol.

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“…After the injury, neural stem cells are attracted to some factors and cross the blood-brain barrier to accumulate at high levels at the injury site; hence, these cells can be targeted for treating neurological diseases such as PD and Frozen disease. AS-IV counters the radiation-induced senescence of brain cells by regulating the p53-p21 and p16-RB senescence-regulated signaling pathways and JNK-p38 phosphorylation [ 38 , 39 ]. Furthermore, the combination of AS-IV and ginsenoside Rg1 augments the protective effects against cerebral ischemic injury via antiapoptotic and anti-inflammatory effects.…”

Section: Neuroprotective Effectsmentioning

confidence: 99%

Pharmacological Effects of Astragaloside IV: A Review

Liang,

Chen,

Liang

et al. 2023

Molecules

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Astragaloside IV (AS-IV) is one of the main active components extracted from the Chinese medicinal herb Astragali and serves as a marker for assessing the herb’s quality. AS-IV is a tetracyclic triterpenoid saponin in the form of lanolin ester alcohol and exhibits various biological activities. This review article summarizes the chemical structure of AS-IV, its pharmacological effects, mechanism of action, applications, future prospects, potential weaknesses, and other unexplored biological activities, aiming at an overall analysis. Papers were retrieved from online electronic databases, such as PubMed, Web of Science, and CNKI, and data from studies conducted over the last 10 years on the pharmacological effects of AS—IV as well as its impact were collated. This review focuses on the pharmacological action of AS-IV, such as its anti-inflammatory effect, including suppressing inflammatory factors, increasing T and B lymphocyte proliferation, and inhibiting neutrophil adhesion-associated molecules; antioxidative stress, including scavenging reactive oxygen species, cellular scorching, and regulating mitochondrial gene mutations; neuroprotective effects, antifibrotic effects, and antitumor effects.

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Section: Introductionmentioning

confidence: 99%

“…Many homologous ingredients of medicine and food, such as polysaccharides, flavonoids, saponins, peptides, alkaloids, and vitamins, have been found to have antiradiation activities. 5 , 6 , 7 As a medicinal and food homologous plant, Acanthopanax senticosus ( AS ) is widely grown in China, and is also often used as a wild vegetable. Previous studies have confirmed the ability of AS to improve learning and memory, increase the number of neurons, prevent brain damage, and have good therapeutic effects on central degenerative diseases and cerebrovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Acanthopanax senticosus extract alleviates radiation‐induced learning and memory impairment based on neurotransmitter‐gut microbiota communication

et al. 2023

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Background Acanthopanax senticosus (AS) is a medicinal and food plant with many physiological functions, especially nerve protection. Its extract has many functional components, including polysaccharides, flavonoids, saponins, and amino acids. Our previous study indicated that AS extract protected against nerve damage caused by radiation. However, little is known about the gut‐brain axis mechanism of AS and its impact on radiation‐induced learning and memory impairment. Method In 60Co‐γ ray‐irradiated mice, we investigated the changes in behavior, neurotransmitters and gut microbiota after different days of administration of AS extract as a dietary supplement. Results The AS extract improved learning and memory ability in mice, and the neurotransmitter levels in the hippocampus and colon started to change from the 7th day, which accompanied changes of the gut microbiota, a decreased abundance of Helicobacter on the 7th day and an increased abundance of Lactobacillus on the 28th day. Among the marker bacteria, Ruminococcus and Clostridiales were associated with 5‐HT synthesis, and Streptococcus were associated with 5‐HT and ACH synthesis. In addition, the AS extract increased the tight junction protein, inhibited inflammation levels in colon, and even increased the relative protein expression of BDNF and NF‐κB and decreased the relative protein expression of IκBα in the hippocampus of irradiated mice. Conclusion These results will lay the foundation for further study on the mechanism of the gut‐brain axis of AS in preventing radiation‐induced learning and memory impairment.

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Preliminary study on the anti-apoptotic mechanism of Astragaloside IV on radiation-induced brain cells

Cited by 9 publications

References 52 publications

Astragaloside IV Ameliorates Myocardial Infarction Induced Apoptosis and Restores Cardiac Function

Astragaloside IV Ameliorates Myocardial Infarction Induced Apoptosis and Restores Cardiac Function

Pharmacological Effects of Astragaloside IV: A Review

Acanthopanax senticosus extract alleviates radiation‐induced learning and memory impairment based on neurotransmitter‐gut microbiota communication

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