Preliminary study on modelling, fabrication by photo-chemical etching and in vivo testing of biodegradable magnesium AZ31 stents

Kandala, Bala Subramanya Pavan Kumar; Zhang, Guangqi; LCorriveau, Capucine; Paquin, Mark; Chagnon, Madeleine; Begun, Dana L.; Shanov, Vesselin

doi:10.1016/j.bioactmat.2020.11.012

Cited by 19 publications

(9 citation statements)

References 49 publications

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“…[ 8 ] Accordingly, substantial efforts, predominantly on the two approaches of alloying and surface modification, have been dedicated to improving the vulnerable corrosion resistance of Mg and eventually to coordinate the degradation behavior with biological response. A series of Mg alloys (AZ31, [ 9 ] WE43, [ 10 ] Mg‐Nd‐Zn‐Zr, [ 8 ] Mg‐Zn‐Y‐Nd, [ 11 ] etc.) have been successively developed in the past decade as potential biodegradable stent materials.…”

Section: Introductionmentioning

confidence: 99%

Incorporating Copper to Biodegradable Magnesium Alloy Vascular Stents via a Cu(II)‐Eluting Coating for Synergistic Enhancement in Prolonged Durability and Rapid Re‐Endothelialization

Zhou²,

Pan

et al. 2022

Adv Funct Materials

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Biodegradable magnesium-based scaffolds present outstanding potential to revolutionize the treatment of coronary artery diseases, in which full recovery of arteries without long-term irritation of implants is anticipated for averting adverse events associated with the permanent stents. However, overfast degradation of magnesium (Mg) alloys obstructs their extensive applications in terms of early structural failure and impaired biocompatibility. Herein, a facile copper-incorporated coating system through nonaqueous phase synthesis of polydopamine is developed to facilitate Cu(II) capture along with robust film deposited on easily corrodible Mg, which subsequently enables sustained Cu(II) elution. It remarkably enhances corrosion resistance and impedes Mg degradation, which also contributes to improved, superior cytocompatibility, and abolished hemolysis. Moreover, through simultaneous control of Cu(II) and Mg(II) release to modulate the local microenvironment, a synergistic biochemical effect on desirable vascular cell selectivity is triggered for boosted endothelial cell viability and suppressed smooth muscle cell. Stent implantation into rabbit abdominal aorta thus exhibits accelerated re-endothelialization completed in a week, and enhanced biological outcomes, alleviated complications and prolonged structural durability in 3-month follow-up. Collectively, this study opens up an alternative route of deploying a multifunctional surface modification strategy tailoring active interplay with the Mg matrix for better outcomes of next-generation bio resorbable vascular stents.

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Section: Introductionmentioning

confidence: 99%

Incorporating Copper to Biodegradable Magnesium Alloy Vascular Stents via a Cu(II)‐Eluting Coating for Synergistic Enhancement in Prolonged Durability and Rapid Re‐Endothelialization

Zhou²,

Pan

et al. 2022

Adv Funct Materials

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“…The combination of Mg 2+ and OH – yields Mg(OH) 2 as the main corrosion product . To date, only a limited number of analytical methods have been developed for the study of the corrosion processes of Mg alloys in biophysiological media, such as electrochemical analysis, − computed tomography (CT) imaging, − weight loss, and hydrogen evolution analysis. − Moreover, these methods cannot in situ monitor the dynamic corrosion processes of Mg alloys. In contrast with these conventional analytical methods, fluorescence imaging has unique advantages for in situ and dynamic monitoring with excellent spatiotemporal resolution (Scheme ).…”

Section: Introductionmentioning

confidence: 99%

Fluorescent In Situ 3D Visualization of Dynamic Corrosion Processes of Magnesium Alloys

Tong

Bian

et al. 2022

ACS Appl. Bio Mater.

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Magnesium (Mg) alloys as implant materials with excellent biodegradation ability have promising clinical applications for tissue repair and restoration. Although the corrosion processes of Mg alloys in biophysiological media are closely related with their biodegradation ability, only limited methods have been developed for characterization of their corrosion processes, including electrochemical analysis, weight loss measurement, and hydrogen evolution analysis. Moreover, these methods suffer from drawbacks of poor spatiotemporal resolution, static observation, and tedious operation. To tackle these challenges, we herein developed a fluorescent probe PSPA for in situ 3D monitoring of the dynamic corrosion processes of Mg alloys on the basis of its selective turn-on detection ability toward magnesium hydroxide [Mg(OH)2], which is the main corrosion product of Mg alloys in biophysiological media. As far as we know, this is the first example of a fluorescent probe for the monitoring of corrosion processes of Mg alloys in biophysiological media. We believe this fluorescence analysis method with easy operation and high spatiotemporal resolution advantages will contribute greatly to the clinical applications of Mg alloy implants.

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“…Metals, ceramics, polymers, and composites are the commonly used orthopedics. Among them, metals are most suitable for wide applications in clinical conditions ( Kandala et al, 2021 ). Ti and its alloys represent a feasible choice among materials for metallic orthopedic implants because of their satisfactory biocompatibility, high corrosion resistance, and excellent mechanical properties ( Geetha et al, 2009 ; He et al, 2015 ; Zhu et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Biodegradability and Cytocompatibility of 3D-Printed Mg-Ti Interpenetrating Phase Composites

Yang

Huang

Zhan

et al. 2022

Front. Bioeng. Biotechnol.

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Orthopedic hybrid implants combining both titanium (Ti) and magnesium (Mg) have gained wide attraction nowadays. However, it still remains a huge challenge in the fabrication of Mg-Ti composites because of the different temperatures of Ti melting point and pure Mg volatilization point. In this study, we successfully fabricated a new Mg-Ti composite with bi-continuous interpenetrating phase architecture by infiltrating Mg melt into Ti scaffolds, which were prepared by 3D printing and subsequent acid treatment. We attempted to understand the 7-day degradation process of the Mg-Ti composite and examine the different Mg2+ concentration composite impacts on the MC3T3-E1 cells, including toxicity, morphology, apoptosis, and osteogenic activity. CCK-8 results indicated cytotoxicity and absence of the Mg-Ti composite during 7-day degradation. Moreover, the composite significantly improved the morphology, reduced the apoptosis rate, and enhanced the osteogenic activity of MC3T3-E1 cells. The favorable impacts might be attributed to the appropriate Mg2+ concentration of the extracts. The results on varying Mg2+ concentration tests indicated that Mg2+ showed no cell adverse effect under 10-mM concentration. The 8-mM group exhibited the best cell morphology, minimum apoptosis rate, and maximum osteogenic activity. This work may open a new perspective on the development and biomedical applications for Mg-Ti composites.

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Preliminary study on modelling, fabrication by photo-chemical etching and in vivo testing of biodegradable magnesium AZ31 stents

Cited by 19 publications

References 49 publications

Incorporating Copper to Biodegradable Magnesium Alloy Vascular Stents via a Cu(II)‐Eluting Coating for Synergistic Enhancement in Prolonged Durability and Rapid Re‐Endothelialization

Incorporating Copper to Biodegradable Magnesium Alloy Vascular Stents via a Cu(II)‐Eluting Coating for Synergistic Enhancement in Prolonged Durability and Rapid Re‐Endothelialization

Fluorescent In Situ 3D Visualization of Dynamic Corrosion Processes of Magnesium Alloys

Biodegradability and Cytocompatibility of 3D-Printed Mg-Ti Interpenetrating Phase Composites

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