Preliminary study on effect of nano-hydroxyapatite and mesoporous bioactive glass on DNA

Ratha, Itishree; Anand, Akrity; Chatterjee, Sabyasachi; Kundu, Biswanath; Kumar, Gopinatha Suresh

doi:10.1557/jmr.2018.114

Cited by 6 publications

(2 citation statements)

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“…The broad absorption band in the range 3300 cm −1 -3600 cm −1 observed for each of the nanocomposite (figure 2 Si-O-Si bending (ν b(Si-O-Si) ) can also be seen at 475 cm −1 in the FT-IR spectra [59]. An additional less intense band observed at 962 cm −1 is due to the non-degenerate P-O symmetric stretch of phosphate group [58].…”

Section: Physico-chemical Characterizationsmentioning

confidence: 99%

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Radiopacity endowed magnetic nanocomposite with hyperthermia and in vitro mineralization potential: a combinatorial therapeutic system for osteosarcoma

2021

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The development of clinically advanced multifaceted therapeutic materials for osteosarcoma is at the forefront of cancer research. Accordingly, this work presents the design of a multifunctional magnetic nanocomposite composed of maghemite, strontium doped hydroxyapatite and silica nanoparticles prospectively holding indispensable therapeutic features such as magnetic hyperthermia, in vitro biomineralization, sustained drug release and intrinsic radiopacity for the treatment of osteosarcoma. The optimal composition has been identified by sequentially modulating the ratio of precursors of the magnetic nanocomposite synthesized by sol–gel technique. Structural and morphological characterization by x-ray diffraction, fourier transform infrared spectrum, Brunauer–Emmet–Teller and transmission electron microscopy analyses followed by VSM, hyperthermia and micro-CT analyses essentially assisted in the selective configuration of biofunctional properties. Results exemplify that MSHSr1 has a saturation magnetization of 47.4 emu g−1 and attained hyperthermia temperature (42 °C) at a very low exposure time of 4 min. MSHSr1 is further unique with respect to its exceptional x-ray attenuation ability (contrast enhancement 154.5% in digital radiography; CT number 3100 HU), early biomimetic mineralization (in vitro) evident by the formation of spheroidal apatite layer (Ca/P ratio 1.33) harvested from FESEM–EDX analysis and controlled release of Doxorubicin, the clinically used chemotherapeutic drug: 87.7% at 120 h in tumour analogous pH (6.5) when compared to physiological pH (71.3% at 7.4). MTT assay complemented with cytoskeleton (F-actin) staining of human osteosarcoma (HOS) cells affirm biocompatibility of MSHSr1. In vitro biomineralization authenticated by Alizarin red S and von Kossa staining has been further corroborated by semi-quantitative calcium estimation of HOS cells cultured with MSHSr1 for two weeks. The results therefore validate the multifunctionality of MSHSr1, and hence could be proposed as a combinatorial therapeutic nanocomposite for osteosarcoma treatment.

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Section: Physico-chemical Characterizationsmentioning

confidence: 99%

“…The intense peaks observed at 1040 cm −1 and 1093 cm −1 for the nanocomposites are associated with asymmetric stretching vibrations of phosphorous bonded to non-bridging oxygen atoms of PO 4 3−groups in HAP[58]. Asymmetric stretching vibrations of Si-O-Si bond (ν s(Si-O-Si) ) in the siloxane group also fall in this range[59]. Characteristic…”

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confidence: 99%

Radiopacity endowed magnetic nanocomposite with hyperthermia and in vitro mineralization potential: a combinatorial therapeutic system for osteosarcoma

2021

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Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration

Niu

Wang

et al. 2021

Carbohydrate Polymers

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Laser Plasma Induced TiO₂ Nanoparticle Synthesis in Water and Particle Characterization

Rajan

Hassan

2019

IEEE Access

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Nanofluids with nanoscale colloidal suspensions having condensed nanomaterials have been found to show highly enhanced physical, chemical, thermal, and transport properties and signify great potential in many fields. In this paper, laser-induced plasmas at liquid-metal phase boundaries are investigated for titanium oxide (TiO 2) nanoparticle synthesis in water without any surfactants. The nanoparticles are generated using 1064 nm NdYAG laser ablation in a water confined plasma with 1.5 J laser energy pulsed at 10 Hz for 4 min, which resulted in nanoparticles of size ranging from 5 to 35 nm. The synthesized TiO 2 nanoparticles in water are characterized for their sizes, surface morphology, crystalline structures, and elemental compositions. The dynamic light scattering (DLS) measurements show the synthesized TiO 2 nanoparticles have an average size of 18 nm. The scanning electron microscopy (SEM) measurements show TiO 2 nanoparticles exhibit isolated and agglomerated nanoparticles with near-spherical and irregular surface morphologies. The Transmission electron microscopy (TEM) measurements show TiO 2 nanoparticles with near-spherical and irregular shapes, and the average size of the nanoparticles is ∼17 nm. The selected area electron diffraction (SAED) measurements show single and poly crystalline structures present in the TiO 2 nanoparticles. The energy-dispersive X-ray spectroscopy (EDX) measurements show the purity of TiO 2 nanoparticles with identification of Ti and O elements. The X-ray diffraction (XRD) measurements confirm that the TiO 2 nanoparticles are crystalline in nature and confirmed the presence and coexistence of two crystal phases of TiO 2 nanoparticles, such as anatase and rutile phases, and estimated nanoparticle size in the range between 11 and 31 nm. INDEX TERMS Nanofluids, nanomanufacturing, laser ablation in liquids, TiO 2 nanofluids, dynamic light scattering, electron microscopy, X-ray diffraction.

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Preliminary study on effect of nano-hydroxyapatite and mesoporous bioactive glass on DNA

Abstract: Abstract

Cited by 6 publications

References 40 publications

Radiopacity endowed magnetic nanocomposite with hyperthermia and in vitro mineralization potential: a combinatorial therapeutic system for osteosarcoma

Radiopacity endowed magnetic nanocomposite with hyperthermia and in vitro mineralization potential: a combinatorial therapeutic system for osteosarcoma

Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration

Laser Plasma Induced TiO₂ Nanoparticle Synthesis in Water and Particle Characterization

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Preliminary study on effect of nano-hydroxyapatite and mesoporous bioactive glass on DNA

Abstract: Abstract

Cited by 6 publications

References 40 publications

Radiopacity endowed magnetic nanocomposite with hyperthermia and in vitro mineralization potential: a combinatorial therapeutic system for osteosarcoma

Radiopacity endowed magnetic nanocomposite with hyperthermia and in vitro mineralization potential: a combinatorial therapeutic system for osteosarcoma

Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration

Laser Plasma Induced TiO2 Nanoparticle Synthesis in Water and Particle Characterization

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Laser Plasma Induced TiO₂ Nanoparticle Synthesis in Water and Particle Characterization