Preliminary study on association between toxoplasmosis and breast cancer in Iran

Kalantari, Narges; Ghaffari, Salman; Bayani, Masomeh; Elmi, Maryam; Moslemi, Dariush; Nikbakhsh, Novin; Ghavipanjeh, Fariedh

doi:10.1016/s2221-1691(15)30169-6

Cited by 22 publications

(22 citation statements)

References 19 publications

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“…11,23 In the study performed by Hassanzadeh et al (2017), 60.3% and 6% of individuals with immunodeficiency were positive for IgG and IgM anti-T. gondii, respectively. 24 In other study by Kalantari et al (2015), 86.4% of women with breast cancer had positive anti-Toxoplasma IgG antibody and 10.3% had positive IgM antibodies. 25 By comparing the results of these studies with the studies mentioned above, it could be conclude that the seroprevalence of T. gondii in Boyer-Ahmad County was not high, which could be attributed to the climatic conditions, cultural habits, geographical location, as well as the sample size.…”

Section: Discussionmentioning

confidence: 89%

“…24 In other study by Kalantari et al (2015), 86.4% of women with breast cancer had positive anti-Toxoplasma IgG antibody and 10.3% had positive IgM antibodies. 25 By comparing the results of these studies with the studies mentioned above, it could be conclude that the seroprevalence of T. gondii in Boyer-Ahmad County was not high, which could be attributed to the climatic conditions, cultural habits, geographical location, as well as the sample size. Findings of the current study revealed that contact with cats is a risk factor for being seropositive for T. gondii in the hemodialysis patients.…”

Section: Discussionmentioning

confidence: 89%

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Seroprevalence and risk factors of Toxoplasma gondii infection among Cancer and Hemodialysis Patients in southwest Iran

Arefkhah

Hosseini

Karimzade

et al. 2019

Clinical Epidemiology and Global Health

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Background: Due to their poor immune system, cancer patients undergoing chemotherapy and hemodialysis patients are more at risk for toxoplasmosis and its complications than the healthy people. The current study aimed to determine prevalence of toxoplasmosis in these patients and comparing it with healthy subjects in southwest Iran. Methods: This cross-sectional study was performed on sera and buffy coat of 100 cancer patients, 47 hemodialysis patients, and 170 healthy subjects. IgG and IgM anti-Toxoplasma gondii antibodies in serum were measured by ELISA method. Molecular diagnosis was conducted by PCR method on buffy coat of the seropositive samples. Results: The seroprevalence of T. gondii in cancer, hemodialysis patients and healthy subjects were 13%, 27.7% and 15.9% respectively. Moreover, seropositivity for IgM antibody was 2.1% in hemodialysis, 2% in cancer patients and 0.6% in healthy individuals. Our results were showed there was no significant difference between prevalence toxoplasmosis in case and control group. In molecular survey, only one case (cancer patient) was positive for Toxoplasma DNA. Contact with cats and consumption of undercooked meat were two studied risk factors which had significant associations with T. gondii seropositivity in the hemodialysis patients (odds ratio [OR] = 14.667; 95% confidence interval [CI] = 1.453-148.045) and control (odds ratio [OR] = 3.07; 95% confidence interval [CI] = 1.093-8.639) respectively. Conclusion: Seroprevalence of toxoplasmosis in hemodialysis patients was higher than Healthy Individuals; however, the seroprevalence of toxoplasmosis in cancer patients was similar to the Healthy Individuals.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 89%

Seroprevalence and risk factors of Toxoplasma gondii infection among Cancer and Hemodialysis Patients in southwest Iran

Arefkhah

Hosseini

Karimzade

et al. 2019

Clinical Epidemiology and Global Health

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“…However, toxoplasmosis has frequently been described to be linked with some particular neoplasms such as acute and chronic leukaemias, lymphoma or multiple myeloma [13,25]. Also, other cancer patients with solid tumours in the breast, ovary and lung, who were under chemotherapy, have been associated with toxoplasmosis [13,26]. In relation to the socio-demographic features of the patients, the seroprevalence of T. gondii was only significantly associated with the level of education of the parents (P = 0.05), and there was no significant association between other socio-demographic data and toxoplasmosis.…”

Section: Discussionmentioning

confidence: 99%

Association between Toxoplasma gondii exposure and paediatrics haematological malignancies: a case–control study

et al. 2018

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The possible association between Toxoplasma gondii infection and paediatric haematological malignancies in a group of patients and control subjects was evaluated in the present study. We performed an age-, gender- and residence frequency-matched case-control study of 101 blood cancer patients under 18 years of age, all of which were treated in Amirkola Pediatric Hospital. One hundred and thirty-eight control samples were gathered from the outpatient clinic in the hospital. All cases and controls were tested for the presence of anti-Toxoplasma IgG antibodies and then IgG-positive subjects were evaluated for IgM antibodies by enzyme-linked immunoassays. Anti-T. gondii IgG antibodies were found in 37 (36.6%) of the cases and 12 (8.7%) subjects in the control group (odds ratio 6.07, 95% confidence interval 2.963-12.437, P < 0.0001). The median and interquartile range (IQR) of IgG titre from case group (7.7 (IQR 0.25-13.5)) was higher than the control (0.2 (IQR 0.1-0.5)) (P < 0.0001). The frequency of anti-T. gondii antibodies (IgG) in lymphoblastic leukaemia (acute lymphoblastic leukaemia), Hodgkin's lymphoma and T-cell lymphoma were 33 (31.9%), 3 (50%) and 1(100%), respectively. Anti-T. gondii IgM was not detected in the IgG-positive patients in case group. In the case subjects, no significant difference was seen in the positive rates of T. gondii infection between genders (37.3% in male; 35.7% in female; P = 0.52) and ages groups (P = 0.31). This study demonstrated that T. gondii infection is prevalent in children with blood cancer. It also showed that toxoplasmosis may possibly be linked with an increased risk of childhood haematologic malignancies. Furthermore, these results may be helpful in research on blood neoplasia aetiology.

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“…The severe infection among these patients due to the low level and the efficiency of the immune system have as a result of cancer and receiving chemotherapy, making them susceptible to many diseases, including toxoplasmosis, especially in the event of exposure to risk factors such as during water contaminated food and eating or contact with cats or dealing with contaminated materials infectious those phases of the parasite (meat, dust and other) (Mahammad and others, 2012; Wang et al, 2015) [8,9]. Khudair (2012) [10] and Kalantari ,N. et al; [11] . The comparison between serums levels of both IgG and marker cancerous Ca19-9 revealed that the values of two variables are increased among cancer patients and toxoplasmosis patients as compared to control ALDujali study and others (2009) [12].…”

Section: Ca19-9mentioning

confidence: 99%

“…Also, the tumor markers cannot be used, also, as an indication for some other cases which are not accompanied by a disease which has been diagnosed with marker Ca19-9 as an indicator of infection for many types of cancer and cancer of the pancreas and colon, stomach, uterus, rectum, ovary, lung, bladder lining. [11] which pointed that the tissue infected with cancer are producing this protein and launched into the blood, so the chance of cancer is high. However, the high Ca19-9 in human`s sera does not give an inevitable consequence of the presence of cancer, as it found that this protein could increase in cases of polyps and malignant.…”

Section: Ca19-9mentioning

confidence: 99%

Prevalence of Toxoplasmosis Among Cancer Patients.

Hamid.¹

2017

IJAR

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Preliminary study on association between toxoplasmosis and breast cancer in Iran

Cited by 22 publications

References 19 publications

Seroprevalence and risk factors of Toxoplasma gondii infection among Cancer and Hemodialysis Patients in southwest Iran

Seroprevalence and risk factors of Toxoplasma gondii infection among Cancer and Hemodialysis Patients in southwest Iran

Association between Toxoplasma gondii exposure and paediatrics haematological malignancies: a case–control study

Prevalence of Toxoplasmosis Among Cancer Patients.

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