Preliminary Study on a Biocompatible Cellulose Waterborne Polyurethane Composite Membrane

Abstract

A promising technique for repairing necrotic mucosa of human organs has emerged, in which composite films are used to replace human mucosa. In this work, neutral alpha-amylase corrosion solution with a concentration of 0.40 mg/mL and hydrochloric acid corrosion solution at pH 0.9 were used as simulated oral cavity and gastric fluid environments under the condition of human body temperature. The prepared cellulose film and the cellulose water-based polyurethane composite film (the concentration of water-based polyurethane was 90, 92, 94, 96, or 98%) were mixed in the simulated environment. The composite membrane had a weaker water swelling property (water swelling degree of 4.32%), weaker surface hydrophilicity (water contact angle of 59.05°), and stronger enzyme activity (1.77 U). This functional film composite material is expected to become an ideal substitute for human mucosa.