Preliminary Study of Sentinel Node Identification with ^99mTc Colloid and Blue Dye in Patients with Endometrial Cancer

Abstract

Our preliminary data suggest that combined 99mTc-labeled colloid and vital blue-dye techniques are feasible for SLA detection in endometrial cancer; they represent a very promising tool to transform the management of early-stage endometrial cancer. The clinical validity of this combined technique should be evaluated prospectively.

Does sentinel node biopsy improve the management of endometrial cancer? Data from 43 patients

“…SLN detection rates in our study were lower than in previous reports: 53.5% by blue dye, 64.3% by radionuclide injection, and 69.0% by both methods combined. In earlier studies, SLN detection rates using combined detection and intracervical injection were 100% [17] and 94.1% [18] (Table IV) [3,[19][20][21][22][23][24][25].…”

“…SLN detection by radionuclide and blue dye injection into the cervix is easy to perform and yields acceptable detection rates in Journal of Surgical Oncology DOI 10.1002/jso [17] 11 Tc 99m þ blue dye (cervix) 100 0% Pelosi et al [21] 16 Tc 99m (cervix) 93.7 0% Barranger et al [18] 17 Tc 99m þ blue dye (cervix) 94.1 0% Lelievre et al [22] 15 Tc 99m þ blue dye (cervix) 93.3 0% Niikura et al [23] 28 Tc 99m (ssm) 82 0% Holub et al [24] 25 Blue dye (ssm þ cervix) 84 0% Frumovitz et al [25] 18 Tc 99m þ blue dye (ssm) 45 0% ssm, subserosal myometrium.…”

Application of Sentinel Lymph Node Dissection in Gynecologic Cancers: Review

“…Yirmi dört LN'den üçünde mikrometastaz bulunmuş ve takip edilen 12 hastada rekürrens olmadığı rapor edilmiştir. 47 Fersis ve ark. SLN'yi histeroskopik pre-operatif peritumoral m-Noncolloid enjeksiyonu ve lenfosintigrafi ile araştırdıkları bir çalışmada, %85,7 sentivite rapor etmişlerdir.…”

Issues surrounding lymphadenectomy in the management of endometrial cancer

“…The same group in 2002 published on testing alternate injection sites of blue dye, demonstrating that successful sentinel lymph node identification was more likely to be achieved by subserosal injections at the level of the cervico-uterine junction than into the subserosal myometrium near the fundus [26]. In 2002, the first report of identification of sentinel nodes with isotope techniques in endometrial cancer was published [27].…”